Health & Medicine News | 麻豆原创 News /news/health/ Central Florida Research, Arts, Technology, Student Life and College News, Stories and More Thu, 30 Jul 2026 17:34:48 +0000 en-US hourly 1 https://wordpress.org/?v=7.0.2 /wp-content/blogs.dir/20/files/2019/05/cropped-logo-150x150.png Health & Medicine News | 麻豆原创 News /news/health/ 32 32 From the Clinic to the Cockpit: 麻豆原创 Opens New FAA-Designated Clinic for Pilots /news/from-the-clinic-to-the-cockpit-ucf-opens-new-faa-designated-clinic-for-pilots/ Thu, 30 Jul 2026 17:34:48 +0000 /news/?p=154402 Through specially administered exams, 麻豆原创 faculty member William 鈥淓d鈥 Powers and his team are helping pilots stay healthy and adhere to the medical standards the FAA requires for safe aircraft operation.

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Minutes from one of the world鈥檚 most visited airports, 麻豆原创 has opened a new clinic to help pilots meet Federal Aviation Administration (FAA) medical requirements to fly safely.

The new 麻豆原创 Aerospace Medicine Clinic at 麻豆原创 Health Faculty Physician Practice in Lake Nona is led by William 鈥淓d鈥 Powers, chief medical officer of 麻豆原创鈥檚 and a certified aviation medical examiner.

Pilots operating civilian aircraft must have various levels of FAA medical certification depending on the type of aircraft. Commercial pilots must pass the exam every six months or each year.

鈥淔light safety depends on healthy pilots,鈥 says Powers, who is certified to conduct the highest level of FAA exams. 鈥淭hat鈥檚 ultimately what we鈥檙e here to support.鈥

“Here at 麻豆原创, we are … connecting medicine, engineering, research and industry in ways few universities can.” 鈥 麻豆原创 President Alexander N. Cartwright

麻豆原创 President Alexander N. Cartwright says the clinic is an example of the university鈥檚 mission to educate talent, advance discovery and solve societal challenges that matter.

鈥淭he next era of flight will bring new demands on health and human performance,鈥 Cartwright says. 鈥淗ere at 麻豆原创, we are meeting those challenges by connecting medicine, engineering, research and industry in ways few universities can.鈥

What sets this clinic apart from others is its ability to more efficiently address the health needs of pilots thanks to a network of 麻豆原创 College of Medicine faculty physicians, university officials say.

The clinic marked its opening with a ceremony today.

Assessing Safety and Minimizing Risk

Medical clearance for pilots is 鈥渁ll about risk,鈥 Powers says. 鈥淭he FAA has to assess the risk of a pilot experiencing a sudden incapacitation while flying. That鈥檚 really what these exams are focused on.鈥

For that reason, the 麻豆原创 clinic will not focus on diagnosing disease, but on identifying and acting on any condition that might endanger pilot, crew and passenger safety.

In addition to a physical exam, pilots must pass hearing and vision tests, including demonstrating that they are not color blind. Airline pilots receive an electrocardiogram every year, while other pilots, like hobbyists, may receive an electrocardiogram if there is evidence of heart disease. Physicians also review medical history and discuss any health concerns that could affect flight safety.

Even manageable chronic conditions like high blood pressure can temporarily delay certification until the condition is treated, stabilized and controlled.

鈥淲hen you鈥檙e flying an airplane, you don鈥檛 have the luxury of pulling over and waiting for help like if you鈥檙e a truck driver,鈥 Powers says. 鈥淵ou must be aware at all times. If you鈥檙e responsible for an aircraft full of passengers, the FAA wants to minimize the chance of a sudden incapacitation.鈥

A Vast Network of Expertise

Complicated medical cases are referred to the FAA for further review, and pilots may need additional interventions to meet certification standards. That鈥檚 where the College of Medicine鈥檚 physician practice offers a distinct advantage, Powers says.

“We can guide pilots to the specialists and testing they need and help them get back on the path toward medical clearance.” 鈥 William “Ed” Powers, chief medical officer of the CASEEM

Unlike private clinics that do pilot certification exams, 麻豆原创 offers multiple medical specialties under one roof and a team approach to care.

鈥淲e can guide pilots to the specialists and testing they need and help them get back on the path toward medical clearance,鈥 Powers says.

Powers brings decades of expertise in space and aviation medicine. Before joining 麻豆原创, he was chief of NASA鈥檚 Medical Operations Branch, director of flight medicine for Axiom Space and director of the aerospace medicine residency program at the University of Texas Medical Branch in Galveston.

Powers also worked inside the FAA as a supervisory medical officer. He says that experience gives him a firm understanding of what the FAA requires, making the process smoother for everyone.

鈥淭hat means fewer delays, fewer mistakes in paperwork and a more efficient process for pilots whose livelihoods depend on getting certified,鈥 he says.

William 鈥淓d鈥 Powers demonstrates part of a hearing test with a standardized patient. Pilots are assessed for hearing, vision, cardiovascular health and more to ensure pilot safety and eliminate the risk of sudden incapacitation.

Strengthening the Regional Aviation Ecosystem

Another 麻豆原创 advantage: the clinic is only about 10 miles from Orlando International Airport, which welcomes 58 million travelers annually. So in addition to local aviators, pilots nationwide who travel to and through Orlando could easily schedule their certification exams at 麻豆原创.

“Clinics like 麻豆原创鈥檚 Aerospace Medicine Clinic [are] helping pilots, whether in space or on the ground, access the care and medical certification support they need to remain flight-ready.” 鈥 Lance Lyttle, CEO of the Greater Orlando Aviation Authority

The clinic will help strengthen the aviation training pipeline in one of the nation鈥檚 most active aerospace regions. This capability is especially important for local flight schools whose students may require guidance in navigating medical certification, return-to-flight concerns and the health demands of aviation careers.

鈥淐entral Florida鈥檚 aviation ecosystem is built on more than runways, terminals and launchpads,鈥 says Lance Lyttle, CEO of the Greater Orlando Aviation Authority, which manages Orlando International and Orlando Executive airports. 鈥淚t also depends on the people and services that keep aviation moving safely and efficiently. Clinics like 麻豆原创鈥檚 Aerospace Medicine Clinic complement that ecosystem by helping pilots, whether in space or on the ground, access the care and medical certification support they need to remain flight-ready.鈥

The clinic is embedded in Central Florida鈥檚 bustling travel hub with numerous satellite airports, including Kissimmee Gateway Airport and Orlando Sanford International Airport. Giving pilots another option to get cleared to fly strengthens the regional economy, says Shaun Germolus, director of aviation for the Kissimmee facility.

鈥淭he aviation industry in Central Florida provides a major economic impact to the region,鈥 Germolus says. 鈥淭he medical exams and certificates provided by the 麻豆原创 Aerospace Medicine Clinic will be very valuable to ensure our aviation professionals are healthy and readily available to serve.鈥

Launching the Clinic

The clinic is starting with limited Thursday and Friday morning appointments to allow the team to refine operations before expanding. Helping coordinate those efforts is Camila Niebla 鈥26, a 麻豆原创 health sciences graduate who now serves as the clinic鈥檚 aerospace medicine navigator.

Niebla discovered aerospace medicine by accident while exploring future career paths before applying to medical school.

鈥淚 didn鈥檛 even know aerospace medicine was a possibility,鈥 she says. 鈥淚鈥檝e always been interested in performance-driven medicine, like sports medicine, so this felt really exciting. It鈥檚 exciting to be part of something from the beginning and watch it grow.鈥

Part of a Larger Vision for Aerospace Medicine at 麻豆原创

The clinic is part of 麻豆原创鈥檚 , which is being developed as a comprehensive academic, clinical, research, education, and operational platform to support the future of aviation, commercial spaceflight, and human space exploration.

鈥淭his is about building the medical infrastructure required for the next era of flight, both on Earth and in space,鈥 says Emmanuel Urquieta, vice chair for aerospace medicine at the 麻豆原创 College of Medicine. 鈥淥ur goal is to create a program that is not only academic, but operational and translational in nature 鈥 one that supports student pilots, flight schools, commercial aviation, spaceflight providers and the broader aerospace ecosystem.鈥

Schedule an Appointment

to learn more about FAA medical exams at 麻豆原创 Health Faculty Physician Practice and schedule an appointment online.

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FAA flight exam William 鈥淓d鈥 Powers demonstrates part of a hearing test with a standardized patient. Pilots are assessed for hearing, vision, cardiovascular health and more to ensure pilot safety and eliminate the risk of sudden incapacitation.
麻豆原创 Students, VA Doctor Develop AI Tool to Help Doctors Identify Chronic Pelvic Pain /news/ucf-students-va-doctor-develop-ai-tool-to-help-doctors-identify-chronic-pelvic-pain/ Tue, 28 Jul 2026 15:30:57 +0000 /news/?p=154477 Through a yearlong internship, two 麻豆原创 undergraduates created an AI-assisted application that helps guide healthcare providers and patients towards accurate diagnosis of the source of chronic pelvic pain.

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For millions of women living with chronic pelvic pain (CPP), finding answers can take far too long.

Studies have shown the condition affects nearly one in four women worldwide and is linked to dozens of potential disorders involving multiple organ systems. Yet many healthcare providers receive only limited training in diagnosing the source of pain, often leaving patients facing years of uncertainty, repeated testing and ineffective treatments before receiving the right diagnosis.

A yearlong collaboration between a 麻豆原创 physician-scientist and two biomedical sciences undergraduate students aims to create a better environment for doctors and patients to reach an understanding together. Biomedical sciences students Sarah Gabriela Nieto Chavarro and second-year Juliana Dimetry interned with Georgine Lamvu, a 麻豆原创 College of Medicine volunteer professor of obstetrics and gynecology, to transform years of international research into a practical tool to help clinicians evaluate patients more quickly and confidently.

The team is developing an AI-assisted clinical questionnaire application that guides physicians through a patient’s symptoms and identifies which organ systems and conditions should be examined. Rather than replacing a physician鈥檚 judgment, the application compiles patient histories quickly to help guide physicians toward making a clearer diagnosis.

From International Research to a Practical Tool

Despite the prevalence of CPP, many healthcare providers lack specialized training in diagnosing the underlying condition because symptoms often overlap with gastrointestinal, urinary, musculoskeletal and reproductive disorders.

鈥淲e鈥檙e hoping that this can become easy to use and can take a detailed medical history that could take an hour to get through down to just 5 to 10 minutes.鈥 鈥 Georgine Lamvu, volunteer professor and Orlando VA practitioner

鈥淲e鈥檙e hoping that this can become easy to use and can take a detailed medical history that could take an hour to get through down to just 5 to 10 minutes,鈥 says Lamvu, who practices at the U.S. Department of Veterans Affairs Medical Center in Orlando and directs its gynecological surgery fellowship program and center. 鈥淭hat allows physicians to have a more efficient evaluation and spend more time with the patient.鈥

The center is a pioneering program designed to address the growing demand for specialized gynecologic care among women veterans. As the number of women veterans using VA healthcare services is expected to increase significantly, this fellowship and center aims to train highly skilled gynecologists to meet their healthcare needs within the VA system and beyond.

As part of that initiative, this project builds upon nearly five years of work led by Lamvu alongside an international coalition of physicians, researchers and patient advocacy groups.

Their research culminated in an international consensus called R U MOVING SOMe, an acronym that categorizes the broad range of symptoms associated with chronic pelvic pain and is the basis of the AI-tool Lamvu and her team developed.

Finding a Definitive Diagnosis

Lamvu says the team translated the clinical research into the logic behind a chatbot-style application that asks fewer than 20 targeted questions. Physicians enter a patient鈥檚 symptoms and history into the program, which then suggests the organ systems and conditions most likely responsible for the pain, helping clinicians focus their evaluation.

The team plans to expand the application beyond patient questionnaires by incorporating physical examination findings into the same scoring system. Ultimately, the researchers say they hope it can be used in any practice that serves women, but it may be years away from being realized.

鈥淧hysicians just need a way of processing all the information that comes from the patient to narrow it down to a differential diagnosis,鈥 Lamvu says. 鈥淩ight now, it鈥檚 all too common to see healthcare workers panic a little when they hear a patient has chronic pelvic pain because it’s considered a complex condition.鈥

Four people posing for a photo
Biomedical sciences students Sarah Gabriela Nieto Chavarro (left) and Juliana Dimetry (right) with Associate Professor of Medicine Kersten Schroeder (second from right), who was instrumental in facilitating the internship with 麻豆原创 College of Medicine Volunteer Professor Georgine Lamvu (second from left) at the Orlando VA.

An Inspiring Internship

The students sifted through years of research and developed the logic for the AI in less than a year. Given the complexity of CPP and the vast amount of data, Lamvu says she is impressed by Dimetry and Nieto Chavarro.

鈥淭hey learned valuable lessons, like if you see a problem that seems unsolvable to everyone else and that directly and negatively impacts patients, you have the power to do something about it,鈥 she says. 鈥淭hese are experiences not every student gets to have, especially this early on in their life.鈥

Dimetry says she challenge intrigued her, and that she was drawn to the project for the opportunity to be at the forefront of medicine and emerging technology.

鈥淚 think that adapting the field of medicine to AI in ways such as this project is necessary to keep medicine growing and advancing,鈥 she says. 鈥淚 also saw how impactful this project could be if done successfully, and I wanted to be a part of that and make a difference,鈥

For Nieto Chavarro, who graduates Summer 2026, the experience showed her how to use technology to help deliver compassionate patient care.

鈥淥n a personal level, this experience has taught me to keep going and to never give up,鈥 Nieto Chavarro says. 鈥淎ll of this has ultimately reinforced how essential it is to genuinely listen to patients so they feel safe and understood鈥

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VA CPP research story with Dr. Lamvu (10) Biomedical sciences students Sarah Gabriela Nieto Chavarro (left), 麻豆原创 College of Medicine Volunteer Professor Georgine Lamvu (second from left) and Juliana Dimetry (right) with Associate Professor of Medicine Kersten Schroeder (second from right), who was instrumental in facilitating the internship. (Photo by Eddy Duryea '13)
麻豆原创 Grads Selected for Veterans Affairs Nurse Practitioner Residency /news/ucf-grads-selected-for-veterans-affairs-nurse-practitioner-residency/ Mon, 27 Jul 2026 13:32:16 +0000 /news/?p=154445 This fall three 麻豆原创 nursing graduates 鈥 including two who are receiving doctoral degrees Saturday 鈥 will begin the highly competitive postgraduate training program at the Orlando VA Medical Center to provide primary care to our nation鈥檚 veterans.

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Three 麻豆原创 graduates have been selected for the Orlando Veterans Affairs (VA) primary care nurse practitioner residency, a highly competitive postgraduate training program at the nation鈥檚 fourth-largest VA medical center.

Only three residents are selected annually from a pool of applicants to participate in the program, in which 麻豆原创 has had consistent representation since its inception. This year, all three spots were awarded to 麻豆原创 graduates 鈥 including two who earn their Doctor of Nursing Practice (DNP) this Saturday during a 麻豆原创 Summer 2026 commencement ceremony.

For , Melissa Fajardo 鈥11 鈥23 and Nancy Saintil 鈥10MS 鈥25DNP 鈥 three first-generation college graduates and two first-generation Americans 鈥 it鈥檚 a career opportunity forged in hard work and shaped by an education at 麻豆原创.

鈥淭his milestone represents years of perseverance, faith, growth and the encouragement of people who believed in my potential,鈥 says Alliance, is among the more than 300 nursing students graduating from 麻豆原创 this week. 鈥淚t is also a reflection of the mentorship, opportunity and support I received throughout my education at 麻豆原创.鈥

“These three 麻豆原创 graduates are highly qualified and will excel in both their residency and future careers as nurse practitioners.鈥 鈥 Jacqueline LaManna 鈥13PhD, 麻豆原创 director of adult primary care nurse practitioner programs

The one-year program is designed to ease the transition into independent practice for newly graduated, licensed nurse practitioners. Nurse practitioner residents rotate through clinical settings with structured mentorship to help care for the 149,000 veterans served by the Orlando VA Healthcare System.

鈥淭his program requires advanced clinical practice, scholarship and leadership skills,” 聽says Jacqueline LaManna 鈥13PhD, 麻豆原创’s director of the adult primary care nurse practitioner programs. “These three 麻豆原创 graduates are highly qualified and will excel in both their residency and future careers as nurse practitioners.鈥

鈥溌槎乖 prepares nurse practitioners for success,” adds Jonathan Decker, director of the family nurse practitioner program. 鈥淥ur graduates鈥 consistently surpass national first-time pass rate averages on board certifications and many secure employment or advanced training opportunities before graduation 鈥 just like these three.鈥

The graduates will begin their residency this fall at the Orlando VA Medical Center in Lake Nona, minutes away from 麻豆原创鈥檚 new Dr. Phillips Nursing Pavilion. The state-of-the-art facility is helping address critical nursing shortages 鈥 awarding more than 900 nursing degrees in the last academic year.

For Saintil, the wife of a veteran, the opportunity is deeply personal.

鈥淭hrough my exposure to the VA healthcare system, I have seen firsthand the positive impact it has on the lives of America鈥檚 veterans,鈥 she says. 鈥淚 am inspired by the VA鈥檚 commitment to providing comprehensive, patient-centered care and honored to contribute to that mission.鈥

Together with their cohort, the three new Knight nurse practitioners are joining one of the nation鈥檚 fastest-growing occupations and meeting increasing demand in Florida. Driven by physician shortages and a growing and aging population, the growth rate of nurse practitioners in the Sunshine State is projected to be 41.6% by 2034.

Meet them here.

Mimi Alliance 鈥22 aims to become a family nurse practitioner known for compassionate, patient-centered care and lasting relationships with those she serves.

Mimi Alliance 鈥22

What inspired your nursing career?
From an early age, I knew I wanted a career in healthcare where I could make a meaningful difference in people鈥檚 lives. As I聽grew older, I became drawn to the structure and mission of public service, particularly organizations with the ability to improve health at both the individual and community level.

How did 麻豆原创 prepare you for practice?
麻豆原创 prepared me through academic rigor, diverse clinical training, faculty mentorship and meaningful opportunities to serve the community. 麻豆原创鈥檚 Family Nurse Practitioner doctoral program challenged me to strengthen my clinical reasoning, communicate clearly, and think beyond the walls of the clinic.

For example, my doctoral project provided hearing screenings for older adults in Central Florida based in 麻豆原创鈥檚 Mobile Health Clinic. Working alongside faculty, providers, audiologists, students and community partners taught me how collaboration can improve preventive care.

As a student who carried significant responsibility early in life, being part of the 麻豆原创 community allowed me to fully experience scholarship, service, leadership and connection.

In the future鈥
My long-term goal is to become an exceptional family nurse practitioner known for compassionate, whole-person care, strong clinical reasoning and meaningful relationships with patients over time.

I also see education as part of my professional identity and hope to continue mentoring future nurses and nurse practitioner students.

Inspired by the hospice nurses who cared for her grandparents, Melissa Fajardo 鈥11 鈥23 traded a 20-year career with the Orange County Corrections Department for a new calling in nursing.

Melissa Fajardo 鈥11 鈥23

What inspired your nursing career?
Nursing is my second career. I initially worked as a first responder and worked with the Orange County Corrections Department for more than 20 years.

I was inspired to pursue a nursing career after watching my grandparents transition through life in the care of the most genuine and loving hospice nursing staff.

How did 麻豆原创 prepare you for practice?
麻豆原创 has been instrumental in my education. I grew up in Massachusetts and was the first in my family to consider attending college. I chose 麻豆原创 for my first degree and have continued to choose 麻豆原创. I love the campus and the education.

The mentorship of my professors, especially in the doctoral program, has given me the confidence to believe in my ability to pursue a higher-level role.

In the future鈥
After completing the residency, my goal is to secure a full-time position with the VA as a family nurse practitioner in one of the primary care clinics in Central Florida.

I come from a long line of veterans, beginning with my grandfather who served in the U.S. Army during World War II, and providing care to veterans is an incredible privilege. While we can never fully repay them for their sacrifices, I believe we have a responsibility to honor them by providing compassionate, high-quality, and respectful healthcare. I want to become the kind of provider who not only manages chronic illnesses, but also empowers veterans to take an active role in their health and ensures they always feel heard, respected and valued.

Nearly 16 years into her nursing career, Nancy Saintil 鈥10MSN 鈥25DNP found a new calling after her father’s stroke: becoming an even stronger advocate for vulnerable patients.

Nancy Saintil 鈥10MSN 鈥25DNP

What inspired your nursing career?
My mom was a nursing assistant, and she encouraged me to pursue a career in the profession. I remember as a child watching her with patients, and I wanted to care for others as she did.

After nearly 16 years in nursing and following my father鈥檚 stroke, I felt called to expand my role in patient care. That experience inspired me to become a stronger advocate for vulnerable populations, including those who may struggle to access or trust the healthcare system.

As a nurse practitioner, I hope to make a meaningful difference by providing compassionate, patient-centered care and serving as a voice for those who need it most.

How did 麻豆原创 prepare you for practice?
麻豆原创 prepared me for my career as a primary care nurse practitioner by combining strong academic instruction with meaningful clinical experiences.

Many of the faculty are practicing nurse practitioners, which allowed them to bring real-world experiences into the classroom. Their expertise, mentorship, and commitment to student success helped bridge the gap between theory and practice and strengthened my readiness to enter clinical practice.

Through rigorous coursework, hands-on lab experiences, and strong clinical partnerships, I gained exposure to diverse patient populations and healthcare settings.

These experiences have equipped me with the foundational knowledge and skills to contribute meaningfully to the VA.

In the future鈥
Upon completion of the residency, I hope to continue serving veterans within the VA healthcare system and build a fulfilling career in primary care, providing compassionate, evidence-based care.

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Mimi-Alliance Melissa-Fajardo Nancy-Saintil
New 麻豆原创 Study Links Microgravity, Space Radiation to Accelerated Aging /news/new-ucf-study-links-microgravity-space-radiation-to-accelerated-aging/ Tue, 07 Jul 2026 14:12:21 +0000 /news/?p=154085 Findings from College of Medicine Professor Michal Masternak and his team suggest spaceflight stressors may accelerate aging in the liver. This discovery could inform future medical research to understand aging on Earth and protect space travelers.

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What happens to the human body in space may help scientists create new anti-aging therapies.

麻豆原创 Professor Michal Masternak and his team have identified molecular changes in the liver that happen when space travelers experience radiation and microgravity. These changes 鈥 that resemble accelerated aging 鈥 provide new insight into how prolonged space missions may increase health risks for astronauts and reveal potential targets for therapies that could combat age-related diseases on Earth.

鈥淛ust 24 hours after radiation exposure, there are many genetic changes in the liver that are remarkably similar to what happens during aging.鈥 鈥 Professor Michal Masternak

鈥淲e focused on the liver because it is one of the major metabolic organs in our body,鈥 says Masternak, leader of the College of Medicine鈥檚 aging and space medicine research efforts. 鈥淲hat we found was that just 24 hours after radiation exposure, there are many genetic changes in the liver that are remarkably similar to what happens during aging. We can assume that if someone were in space much longer, the damage could be much greater.鈥

The findings were recently published in聽GeroScience.

Portrait of bald man wearing glasses and white lab coat standing in front of blue lab bench
Professor Michal Masternak says the space industry provides unique opportunities to study aging at an accelerated pace. (Photo by Eddy Duryea 鈥13鈥)

 

Navigating the Science

For their study, 麻豆原创 researchers and scientists from the U.S. created a simulated deep space environment in the lab. The team exposed animal models to simulated microgravity for 14 days and galactic cosmic radiation and solar particle events at NASA Space Radiation Laboratory trying to mimic the dosage that astronauts would be exposed to during a trip to Mars.

The exposure triggered noticeable and potentially harmful changes in the liver, including increased cellular senescence (aging and decreased cell function), inflammation and fibrosis. Left untreated, these conditions can eventually lead to declining and even failing organ function.

The research team then compared their results with data collected from astronaut blood samples taken during the NASA Twins Study and Inspiration4 astronauts. They saw similar genetic changes in blood.

鈥淲e鈥檝e got this raw data from human studies, and they show that some of these changes are similar,鈥 Masternak says. 鈥淭hat tells us we鈥檙e identifying useful molecular targets that one day could help protect astronauts during long-duration space missions.鈥

They聽also聽went a step further to see聽whether the聽changes could be treated. They聽identified聽a group of molecules known as antagomirs that alter several aging and inflammatory genetic pathways聽by interacting with the body鈥檚聽microRNA. This system could pinpoint promising聽future聽therapies for space travelers.

Three men and one woman dressed in white lab coats and blue gloves on their hands stand shoulder to shoulder in lab setting
(From left to right): Biotechnology graduate student Sarah Siddiqi, researcher Mishfak Mansoor, 麻豆原创 Professor Michal Masternak and biomedical sciences doctoral student Md Tanjim Alam. (Photo by Eddy Duryea 鈥13鈥)

Understanding Aging in the Space Age

Masternak says聽the nation鈥檚聽growing space industry provides a unique opportunity to study aging at an accelerated pace.

鈥淰ery often when we study different aging processes, it takes time,鈥 he says. 鈥淓ven in humans, it鈥檚 almost impossible because it would take decades. But if we see some acceleration of aging in space, then we can translate it to human studies. We can observe processes happening much faster, understand them better and eventually use that knowledge to improve health for people here on Earth.鈥

鈥淚f we see some acceleration of aging in space, then … we can observe processes happening much faster, understand them better and eventually use that knowledge to improve health for people here on Earth.鈥 鈥 Masternak

Those discoveries could eventually lead to therapies that slow age-related diseases, preserve organ function and improve quality of life for everyone as they age.

鈥淥ur understanding of aging is very complex,鈥 Masternak says. 鈥淎ging isn’t simply wrinkles or cosmetic changes. It鈥檚 the gradual and cascading failure of multiple organs and biological systems that happen at the same time. By understanding what starts that process and where it happens, we have a better chance of preventing many diseases before they develop. That is one of the biggest outstanding questions.鈥

Students Positioned at the Forefront of Space Medicine

College of Medicine students are also benefitting from space medicine research. Biomedical sciences Ph.D. student Md聽Tanjim Alam聽鈥25MS聽joined Masternak’s laboratory during his聽biotechnology聽master’s program after initially planning to study cancer in relation to aging biology. Then he was introduced to space medicine, including processing astronaut samples from commercial space travelers to study how extreme environments affect human biology. That research has inspired him.

鈥淚 want to keep exploring the unknown,鈥 Alam says. 鈥淚 really want to understand how space travel influences human health, particularly its effects on aging and cancer.鈥

叠颈辞迟别肠丑苍辞濒辞驳测听驳谤补诲耻补迟别听蝉迟耻诲别苍迟听厂补谤补丑听厂.听厂颈诲诲颈辩颈听鈥24听says the interdisciplinary nature of the research attracted her to the space medicine and aging lab.

鈥淲hen people think of aging, they think only about elderly populations,鈥 says Siddiqi, who earned her bachelor鈥檚 degree as a Burnett Honors Scholar in biomedical sciences. 鈥淏ut we study aging across different stages of life and different environments, including space. I’ll always be focused on improving quality of life. I want to better understand diseases that are increasingly prevalent and find ways to recognize them earlier, before they progress to later stages.鈥


Funding and Disclosure:

搁别辫谤别蝉别苍迟颈苍驳听鲍颁贵,听Natalie Hayslip聽鈥24聽served as first author, while聽Sarah Ashiqueali聽鈥21MS 鈥24PhD, Xiang Zhu, Ridwan Hussein聽鈥22聽and聽Mishfak聽Mansoor also contributed to the research.聽Researchers from聽Rensselaer Polytechnic Institute, Weill Cornell Medicine,聽Universidade聽Federal de Pelotas,聽the聽University of聽Pittsburgh聽and聽the聽University of North Carolina at Chapel聽Hill聽also聽contributed.

This work was supported by the National Science Foundation Award Number (FAIN): 2317758(MMM), Ed and Ethel Moore Alzheimer鈥檚 Disease Research Program of the聽Florida Department of Health,聽Public Health Research, Biomedical Research Program聽24A12 (MMM), and the National Science Centre, Poland UMO-2023/51/B/NZ5/00498 (MMM).

Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the awarding agencies.

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Dr. Masternak and students, space aging research-medicine Professor Michal Masternak says the space industry provides unique opportunities to study aging. Michal Masternak-麻豆原创-space-aging-research From L to R: Sarah Siddiqi, Mishfak Mansoor, Dr. Michal Masternak and Md Tanjim Alam. (Photo by 麻豆原创 College of Medicine)
麻豆原创 Students Reimagine Clothing Through Adaptive Design /news/ucf-students-reimagine-clothing-through-adaptive-design/ Tue, 30 Jun 2026 15:49:56 +0000 /news/?p=154001 At 麻豆原创’s Rehabilitation Innovation Center, teams of students from different disciplines are transforming everyday clothing into life-changing solutions for people with disabilities and medical challenges.

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At the聽麻豆原创聽College of Health Professions聽and Sciences Rehabilitation Innovation Center, clothing becomes a tool for care. Students are combining health expertise and design to help people reclaim independence, confidence and comfort in daily living.

Through the Spring 2026 Health Tech Innovators Adaptive Clothing Hackathon, students across disciplines including physical therapy, health sciences, medicine, health services administration, and engineering worked together to redesign everyday garments around the needs of people facing medical, cognitive, and sensory challenges.

This year鈥檚 project immersed students in real world healthcare challenges, pairing interprofessional teams with patient volunteers in the community and their caregivers to identify barriers created by traditional clothing and create personalized solutions.

鈥淚t鈥檚 one thing to build something that works,鈥 says Associate Dean of Clinical Affairs and Healthcare Innovation Bari Hoffman, who led the program. 鈥淚t鈥檚 another thing to build something that鈥檚 usable, comfortable and actually fits into someone鈥檚 daily activities.鈥

Young blonde boy stands in front of classroom wearing a blue shirt with a red pouch as three adults stand around him.
Interprofessional student teams showcased their adaptive clothing designs in a final presentation in which patient volunteers modeled the garments. (Photo by Grayson Keglovic)

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For聽physical therapy聽doctoral student Ashley Peitz, the project revealed how something as ordinary as getting dressed can become physically exhausting when clothing isn鈥檛 designed with accessibility in mind.

鈥淲e鈥檙e working with a stroke survivor, and he wears a device on his left leg and has difficulty getting pants on and off without聽his聽[WalkAide聽device]聽getting in the way,鈥 Peitz says.聽鈥淚t makes things like going to the bathroom take longer, or just getting dressed take a little longer, which is fatiguing for him.鈥

Students began the multi-month project by hearing from entrepreneurs in the adaptive clothing industry before interviewing and assessing their patient volunteers to better understand their daily routines, needs and personal preferences.

For Peitz鈥檚 team, those conversations revealed not only the physical challenges their volunteer faces, but also his desire to maintain a sense of normalcy and personal style.

鈥淗is main goal was finding an easier way to take his garments on and off while still looking like everyday attire,鈥 Peitz says.聽鈥淓veryone wants to fit in.聽Even something as simple as not having a shirt that fits correctly,聽or allows for your medical device to fit underneath,聽can make you feel outside the norm.鈥

滨苍苍辞惫补迟颈辞苍听罢丑谤辞耻驳丑听贰尘辫补迟丑测

After developing a garment design plan, presenting it for peer feedback and securing materials, students quickly learned the project required more than creativity. It demanded adaptability, communication and collaboration across disciplines.

鈥淚 think a lot of times, engineers think of聽a聽really cool, innovative聽idea, but sometimes the聽comfort聽and practicality of a human actually using it isn鈥檛 the most ideal,鈥澛爏ays聽mechanical engineering聽major聽Jannah聽Barakat. 鈥淵ou shift from more of a product standpoint to聽more of a聽human-centered聽approach.鈥

鈥淚’m able to be a professional problem solver and learn how I can take something that is different for somebody else and really cater it to their needs.鈥 鈥 Sari Greenstein, 麻豆原创 student

Health sciences聽major Sari Greenstein and her team designed clothing for Marlie, a young girl with cerebral palsy who loves bright colors and Disney, especially Princess Tiana. They modified a sweatshirt and sweatpants with openings for a medical port and feeding tube and added zippered access points to the arms and the legs to make dressing and undressing easier for caregivers.

鈥淚t’s a process聽[with]聽a lot of聽iteration聽and a lot of cultivation,鈥 Greenstein says.聽鈥淚’m able to聽be a professional problem solver and learn how I can take something that is different for somebody else and really cater it to their needs.鈥

Two young women sit at table cutting pieces of purple fabric
Students researched user needs, learned garment fabrication skills, and designed adaptive clothing solutions to improve comfort, accessibility, and independence for individuals with medical needs. (Photo by Grayson Keglovic)

Mission-Driven Work

During fabrication day, students assembled their garments with guidance from sewing professionals. Volunteers later returned to try on the finished outfits and provide feedback on the fit before final adjustments were made.

The project culminated in a final presentation during which student teams explained their designs and the patient volunteers modeled the clothing.

鈥淲e are not just changing clothing,鈥 Hoffman says. 鈥淲e鈥檙e actually changing how people move through their daily activities, how they feel about themselves and how independently they can live.鈥

The experience also reinforced the value of interdisciplinary collaboration in healthcare.

鈥淢y biggest takeaway from this聽project is how important it is to work with all the other professions, especially in healthcare,鈥澛燩eitz says. 鈥淲e all need to come together to make the patient鈥檚 health our first priority.鈥


The Health Tech Innovators聽program was developed in part through a grant from VentureWell to promote innovation in healthcare technology.聽础诲诲颈迟颈辞苍补濒听蝉upport and materials were provided聽迟丑谤辞耻驳丑听funding from the Chesley G. Magruder Foundation.

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ucf-adaptive-clothing-young-boy Interprofessional student teams showcased their adaptive clothing designs in a final presentation in which patient volunteers modeled the garments. ucf-adaptive clothing solutions Students researched user needs, learned garment fabrication skills, and designed adaptive clothing solutions to improve comfort, accessibility, and independence for individuals with medical needs.
麻豆原创-Led VERA Project Reaches 2 Major Milestones for VR Research /news/ucf-led-vera-project-reaches-2-major-milestones-for-vr-research/ Wed, 24 Jun 2026 14:30:23 +0000 /news/?p=153896 The Virtual Experience Research Accelerator (VERA), a聽U.S.聽National Science Foundation-funded platform聽designed to advance the pace and scope of immersive research, has launched its first large-scale remote study and awarded its first聽use聽grant聽to address key聽challenges聽in聽VR and immersive learning.

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After years of research and development聽led by聽experts at聽麻豆原创聽in collaboration with researchers聽from聽universities across the U.S.聽and in Europe, the Virtual Experience Research Accelerator (VERA) has reached two major milestones: powering its first full-scale study to address one of virtual reality鈥檚 most persistent barriers to adoption and awarding its first use grant聽to enhance immersive learning and information聽across industries.

VERA, a聽platform funded by the聽U.S.聽National Science Foundation, is the first, large-scale system for extended reality human subjects research and designed to advance the speed, scale and scope of immersive research. The platform enables immersive researchers to design, deploy, and manage virtual and augmented reality (VR/AR) studies with remote participants therefore significantly improving the quality of the science, while reducing costs, lowering logistical barriers and expanding participant reach.

鈥淣o one has built anything like VERA before,鈥 says Pegasus Professor Gregory Welch, lead principal investigator on VERA. 鈥淭he team was really starting from scratch to create this national platform, integrating AI technologies and establishing policies and procedures that will produce methodologically rigorous behavioral data.鈥

鈥淲e鈥檙e excited for VERA to聽now聽start聽to run聽in an open beta mode and reach these two firsts,鈥澛燱elch continues.

Scene of a carnival with a ferris wheel in background and white ride carts in the foreground from a VR simulation
Cybersickness occurs when symptoms such as nausea, dizziness and discomfort are caused by a mismatch between visual motion in a headset and the user鈥檚 physical motion.

Accelerating Understanding of Cybersickness

For its first major large-scale study聽leveraging聽remote participants, VERA is helping researchers address one of the most persistent challenges in virtual reality: cybersickness.

Cybersickness occurs when symptoms such as nausea, dizziness and discomfort are caused by a mismatch between visual motion in a headset and the user鈥檚 physical motion. Associate Professor of Computer Science Gerd Bruder, who is an affiliate researcher in the Institute of Simulation and Training, is leading the research study in collaboration with other 麻豆原创 researchers and external partners.

鈥淯nderstanding聽who is聽susceptible聽to cybersickness is critical to improving VR accessibility,聽making聽VR聽more comfortable for all users聽and聽enabling聽broader adoption across research, education and industry,鈥 Bruder聽says.

Early data collection highlights the聽powerful聽capabilities of the VERA platform to accelerate VR research at an unprecedented scale.

In just 15 cumulative days, VERA had more than 250 participants聽complete聽the full study protocol. In comparison, the聽original in-lab study collected data from聽just聽30 participants聽and in traditional VR research聽settings,聽studies with hundreds of participants often require several months to complete.

For the study, each participant experiences a controlled VR rollercoaster ride on their own headset and provides sickness ratings at periodic intervals, a pre- and post- exposure questionnaire, an in-VR visual acuity assessment, and continuous head-tracking data. Each session is completed in approximately 30 minutes at home.

鈥淭he sectors where VERA can make an impact聽are聽expansive, from healthcare to workforce training to accessibility to learning.鈥

Enrollment is ongoing with a target of 2,000 participants. Preliminary analyses already suggest meaningful individual differences in how quickly and severely participants experience cybersickness.

鈥淰ERA was built to study problems like this with a combination of speed, scale and experimental complexity not previously possible,鈥 Welch says. 鈥淭he sectors where VERA can make an impact are expansive, from healthcare to workforce training to accessibility to learning.鈥

AdventHealth Endowed Chair in Healthcare Simulation Greg Welch (left) and Associate Professor Gerd Bruder from 麻豆原创鈥檚 Institute for Simulation and Training (right) are leading the VERA initiative and first study.

Groundbreaking Immersive Learning Project

For the first project selected in its Use Grant program, VERA is supporting innovative research to study how different immersive technologies engage learners in different ways. The study will help inform how to leverage emerging technologies in education, cultural institutions, public engagement and more.

The grant was awarded to the聽San Jos茅 State University School of Information Library Technology Integration Lab in Silicon Valley and New Media Learning,聽one of the largest providers of virtual reality programming in public libraries.

The project will support a collaborative virtual reality research environment integrated with VERA with participants from across the U.S. in public libraries, universities and other sites.

Researchers will collect behavioral and interaction data including attention patterns, object interaction, navigation pathways, movement, clicks, engagement metrics, and time-on-task, supplemented by surveys and participant feedback. The resulting research environment will serve a scalable prototype for future applications to make immersive learning experiences more accessible to communities worldwide.

A distinguishing feature of the project is the active involvement of San Jos茅 State University undergraduate and graduate students from the School of Information who will work alongside faculty researchers and technology partners to gain hands-on experience.

鈥淏eing selected as the first VERA Use Grant recipient is both an honor and an extraordinary opportunity,鈥 says Anthony S. Chow, professor in the San Jos茅 State University School of Information and founder of the Library Technology Integration Lab. 鈥淭hrough this collaboration, we hope to generate research that helps libraries, educators, museums and community organizations leverage virtual reality to address some of society鈥檚 most important challenges while creating meaningful research opportunities for students.鈥

鈥淲e are excited to welcome聽San Jos茅 State University聽and New Media Learning as the first recipients of a VERA聽Use聽Grant,鈥 Welch聽says. 鈥淭heir聽expertise聽in libraries, immersive learning, public聽engagement聽and emerging technologies makes them ideal partners聽for聽demonstrating聽how VERA can accelerate impactful XR research. We believe this collaboration will help聽establish聽new models for studying learning, engagement, and information behavior in immersive environments.鈥

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ucf-VERA-gregory welch-cybersickness Cybersickness occurs when symptoms such as nausea, dizziness and discomfort are caused by a mismatch between visual motion in a headset and the user鈥檚 physical motion. bruder-port AdventHealth Endowed Chair in Healthcare Simulation Greg Welch (left) and Assistant Professor Gerd Bruder from 麻豆原创鈥檚 Institute for Simulation and Training (right) were honored for their innovative work.
麻豆原创 Researcher Studying Probiotics to Fight Acid Reflux, Esophageal Cancer /news/ucf-researcher-studying-probiotics-to-fight-acid-reflux-esophageal-cancer/ Wed, 03 Jun 2026 13:00:37 +0000 /news/?p=153513 Associate Professor Claudia Andl is examining how a simple probiotic can treat the damage from acid reflux disease, a condition that affects one-fourth of Americans and increases their risk for esophageal cancer.

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Patients with acid reflux, which occurs when stomach acid pushes up into the esophagus, know the symptoms all too well: heartburn, belching, chest pain and trouble swallowing. In addition to these ailments, acid reflux also increases the risk of esophageal cancer, which has a five-year survival rate of about 22%, according to the American Cancer Society

麻豆原创 College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions..

麻豆原创 College of Medicine Associate Professor Claudia Andl, a throat and oral cancer researcher, is investigating how a simple probiotic could treat and prevent both conditions. The research is funded by a one-year, more than $380,000 grant from the Florida Department of Health鈥檚 Florida Cancer Innovation Fund.

Probiotics are live microorganisms 鈥 usually bacteria or yeasts 鈥 that support and strengthen health by increasing the body鈥檚 population of healthy cells. Many people take probiotics to improve gut health and digestion. Andl鈥檚 research is focused on using a healthy bacteria called Lactobacillus spp. to treat esophageal damage caused by acid reflux and improve the microbial environment in the esophagus to reduce the risk of cancer.

In patients with acid reflux 鈥 as well as gastroesophageal reflux disease (GERD), a chronic and more severe form of the digestive condition 鈥 stomach acid burns through the lining of the esophagus, causing inflammation and DNA damage to surrounding cells. Over time, those cellular changes can create a condition called Barrett鈥檚 esophagus, which increases the risk for esophageal cancer. In addition, when the throat鈥檚 bacterial environment becomes dominated by stomach acids and salts, healthy bacteria struggle to survive. Harmful bacteria take their place, causing further cell damage and inflammation that increases cancer risk. Introducing Lactobacillus spp. into disease models has solved both issues.

鈥淲e all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs. And it鈥檚 the same in the esophagus.鈥

鈥淭he reintroduction of beneficial bacteria works two-fold,鈥 Andl says. 鈥淚t restores a normal environment again, but also these Lactobacilli are known to suppress inflammation and repair the DNA damage.鈥

鈥淲e all talk about how important it is to eat yogurt or drink kombucha so that we maintain a healthy bacterial residence in all your organs,鈥 Andl continues. 鈥淎nd it鈥檚 the same in the esophagus.鈥

Early results have shown a reduction in Barrett鈥檚 esophagus, and if cancer develops at all, it occurs much later than in models not treated with the probiotic.

Andl says she hopes her research will inform new therapies and provide more information on how to keep the body鈥檚 microbial balance healthy to fight disease. She notes this is especially important as data also shows Barett鈥檚 esophagus and esophageal cancer are increasing in patients under ages 60-70, the average age for these patient populations.

鈥淲e aim to improve outcomes for the large number of reflux patients at risk for cancer,鈥 Andl says. 鈥淧laying a role in that would be incredibly rewarding.鈥

Andl joined 麻豆原创 in 2016 after receiving her Ph.D. in cell biology from the University Duisburg-Essen in Germany and conducting postdoctoral research at the University of Pennsylvania.


This research is sponsored by the Florida Cancer Innovation Fund and the Florida Department of Health.

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麻豆原创 Scientist Leads Research to Break Through Harmful Bacterial 鈥淔ortresses鈥 /news/ucf-scientist-leads-research-to-break-through-harmful-bacterial-fortresses/ Mon, 01 Jun 2026 13:19:55 +0000 /news/?p=153496 Continuing her work with antibiotic-resistant bacteria, Renee Fleeman is understanding how a bioengineered peptide can curb severe infections for patients.

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College of Medicine聽Assistant Professor聽Renee Fleeman聽continues聽to refine a powerful聽therapy for drug-resistant bacteria that pierces the gooey coating that anchors and protects such germs from the drugs we take to kill them.

贬别谤听research, backed by a five-year $813,130 National Institute of Allergy and Infectious Diseases grant, found that an antimicrobial peptide naturally found in cows weakens the biofilm defenses of Klebsiella pneumoniae bacteria and destroys it.

Now in their fourth year of research, Fleeman and her lab have discovered exactly how the peptide works in findings published in PLOS Pathogens.

鈥淥ur research is very advantageous for healthcare because about 80% of bacterial infections being treated in the clinic are bacteria living in a biofilm state, which makes them resistant to virtually every antibiotic available,鈥 she says.

The results聽represent聽a critical step to potentially applying this peptide as a therapy and eventually treating patients,聽as the findings聽show they can and kill biofilm-embedded bacteria in animal models.

Man wearing black glasses and white lab coat holds up dish with jelly circles between his blue gloved hands
Robert Beckman 鈥23 shows an isolated experiment that demonstrates how their peptide kills K. pneumoniae, which is a critical step before testing in animal or human models.

Parsing out the Peptide

K. pneumoniae is found in the intestines and is usually harmless, however, the bacterium develops resistance over a person鈥檚 lifetime as they are exposed to antibiotics. The bacteria also can spread from the intestine to other parts of the body in immunocompromised patients and those who have internal ruptures or exposure to contaminated medical devices. That exposure can lead to pneumonia, urinary tract or wound infections.

鈥淲hat happens is the bacteria聽infects聽the wound, proliferates, and then invades through the bloodstream聽where it travels聽to the liver, kidneys and spleen,鈥 Fleeman聽says. 鈥淲e聽found聽our peptide聽was able to decrease the bacteria聽at the source while limiting聽the bacteria鈥檚聽ability to move聽through the blood.鈥

Fleeman and her lab鈥檚 most recent study found that the peptide triggers a dual stress response that tricks the bacteria to break out of their protective biofilm.

They discovered the genetics of a specific protein in the bacterium when turned on in the germ causes it to break from its own protective biofilm. The peptide, in effect, damages the protection and then stresses the bacterium into shedding its protection, making the germ more sensitive to antibiotics and the body鈥檚 immune system.

鈥淏y聽hitting the membrane as well as protein synthesis at the same time, it’s聽a double punch that triggers a genetic聽change聽in the cell to make it think it needs to break out of聽the biofilm as a response to our peptide,鈥 Fleeman聽says.

The team says their sustained research aims to demonstrate that their peptide can work synergistically with existing antibiotics. They envision long-term applications could involve a topical cream that weakens the bacteria鈥檚 defenses and allows standard antibiotics to work more effectively.

鈥淲e鈥檙e moving our research聽forward聽and we鈥檙e very hopeful,鈥 Fleeman聽says.

Dr. Renee Fleeman stands with mixed group of six men and women, all in white lab coats, with shelves of lab equipment around them.
Renee Fleeman鈥檚 lab group is comprised of students who, under Fleeman鈥檚 mentorship, gain valuable research experience. (Photo by Kadeem Stewart)

Preparing for the Post-Antibiotic Era

The first author of this new work聽is聽Robert Beckman聽鈥23, who graduated聽from 麻豆原创聽with a聽bachelor鈥檚 degree in health sciences,聽managed聽Fleeman鈥檚 lab聽and is now on his way to聽the University of Michigan聽for his Ph.D.

His聽previous聽work as an EMT gave him firsthand exposure to聽infectious diseases and their impact on聽patients.聽He聽says聽helping to lead the study and聽working with聽Fleeman helped prepare him for a career in medical research.

鈥淚 have developed a strong foundation in research and gained insight into the many components that define an effective scientist,鈥 he聽says. 鈥淢y long-term goal is to remain in academia and eventually lead my own research lab.聽I plan to continue focusing on bacteriology, with a particular emphasis on pathogenic bacteria and drug discovery applications.鈥

Funding and Disclosure:

Research reported in this publication was supported by the National Institute聽of Allergy聽and Infectious Diseases of the National Institutes of Health under Award Number R00AI163295. The content is solely the responsibility of the authors and does not necessarily聽represent聽the official views of the National Institutes of Health.

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Robert Backman lab (14) Robert Beckman 鈥13 shows an isolated experiment that demonstrates how their peptide kills K. pneumoniae, which is a critical step before testing in animal or human models. Fleeman and lab students Renee Fleeman鈥檚 lab group is comprised of students who, under Fleeman鈥檚 mentorship, gain valuable research experience. (Photo by Kadeem Stewart)
麻豆原创 Materials Science and Engineering Alum Recognized for Medical Device Innovation /news/ucf-materials-science-and-engineering-alum-recognized-for-medical-device-innovation/ Thu, 21 May 2026 13:30:28 +0000 /news/?p=153241 Cacie McDorman 鈥20 earned Alleima Advanced Materials’ 2026 Innovation Prize for her work advancing wires used in critical medical devices.

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The ultra-fine wires Cacie McDorman 鈥20 helps develop are small in size but transformative in impact.

Now a global project manager for wire technology at Alleima Advanced Materials, the materials science and engineering alum has earned the company鈥檚 2026 Innovation Prize for her work advancing wires used in critical medical devices such as continuous glucose monitors, hearing implants and pacemakers. The annual award recognizes excellence in product development.

鈥淭he work I do is very rewarding. Every day, I get to contribute to advancing medical care and treatment,鈥 McDorman says. 鈥淚f it鈥檚 a medical device and it has a wire, Alleima is likely contributing to it somehow.鈥

Woman wearing glasses and a dark blazer smiles in a professional headshot against a white background.
麻豆原创 alum Cacie McDorman 鈥20 serves as global project manager for wire technology at Alleima Advanced Materials.

McDorman earned her doctoral degree from 麻豆原创 under Associate Professor Swaminathan Rajaraman, who directs the , where researchers develop micro- and nanoscale solutions spanning biotechnology, pharmacology, plant sciences and medical devices.

鈥淚 chose 麻豆原创 because the [materials science and engineering] program was highly rated … and had a wide variety of research areas …鈥

Before coming to 麻豆原创, McDorman earned her master鈥檚 and bachelor鈥檚 degrees in physics, but discovered a passion for applied research that required a deeper focus on materials.

鈥淲hen I decided to pursue a Ph.D., materials science and engineering was a natural choice,鈥 she says. 鈥淚 chose 麻豆原创 because the program was highly rated, small and had a wide variety of research areas that I was interested in.鈥

Through her doctoral studies, McDorman found a more biology-focused side of materials science. Her work with biosensors in Rajaraman鈥檚 lab ultimately inspired her to pursue a career in the medical device industry.

She credits her research experience at 麻豆原创 with preparing her for work at Alleima, where 90% of her unit鈥檚 business supports medical device manufacturing.

鈥淭he company has a rich history of materials innovation in steel and nickel-based alloys,鈥 McDorman says. 鈥淪ince we produce wire, I am constantly using base materials science knowledge to process the material in a way that achieves a specific set of properties in the end product.鈥

She says she has always aimed for a position that would allow her to make a positive contribution to society, an opportunity she is grateful to have at Alleima.

For new graduates considering a similar path, McDorman encourages them to connect with 麻豆原创 alumni on LinkedIn and to explore job opportunities in Florida鈥檚 growing manufacturing industry, particularly in Volusia and Flagler counties.

鈥淲e put a lot into our work every day because we truly care about ensuring the best possible patient outcomes,鈥 she says. 鈥淚t is great that our efforts have been recognized by the business.鈥

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麻豆原创 Researcher Develops 鈥淪mart, Tiny Bubbles鈥 to Treat Cancer and Heart Disease /news/ucf-researcher-develops-smart-tiny-bubbles-to-treat-cancer-and-heart-disease/ Wed, 20 May 2026 14:21:52 +0000 /news/?p=153299 Dinender Singla developed innovative technology and has formed a company to get the treatment ready for clinical trials.

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A cell 500 times thinner than a human hair could heal hearts and kill cancer cells, thanks to a patent-pending technology created by a 麻豆原创 researcher and now licensed to a university donor in hopes of getting it to clinical trials.

Dinender Singla, professor and head of the College of Medicine鈥檚 Division of Metabolic and Cardiovascular Sciences, developed a system that turns exosomes 鈥 vesicles that cells secrete to communicate with one another 鈥 into delivery vehicles for medical treatments.

This innovative technology, for which 麻豆原创 is seeking patent protection, places therapeutics inside exosomes and coats them with cell-specific markers that direct them to an exact area of the body to deliver the drug.

鈥淚 call these smart tiny bubbles,鈥 Singla says. 鈥淢illions of people have heart disease, and they take multiple drugs in extremely high doses. But we have no way to be certain these drugs are getting to where they need to go. We need innovative technologies to get treatments exactly where they need to go to cure the problem.鈥

Two men and a woman in white lab coats stand to right of computer monitor, which is flanked on the opposite side by two men in business coats.
From left to right: Research Scientist Chandrakala Aluganti Narasimhulu, Jonatas De Mendonca Rolando ’23MS ’26PhD,聽 a 麻豆原创 post-doc, 麻豆原创 doctoral student Omonzejie Imaralu 鈥22MS, Dinender Singla and Chakri Toleti.

How the Therapy Works

This discovery is part of Singla鈥檚 work to provide therapies to treat and prevent heart disease, including heart damage caused by cancer treatments such as chemotherapy and targeted radiation to the chest. That heart damage seems to be caused by inflammatory factors that treatments use to kill cancer cells. Technology developed by Singla encapsulates anti-inflammatory heart treatments in exosomes and then delivers the drug to the exact area of heart damage.

鈥淭hey can treat cancer and protect the heart.鈥 鈥 麻豆原创 Professor Dinender Singla

As part of this research, Singla鈥檚 team also developed technologies to deliver cancer-killing drugs inside exosomes. They chose triple-negative breast cancer for their research, the deadliest form of the disease, with a 77%鈥78% five-year survival rate. In the lab, the therapy showed significant promise in killing cancer cells 鈥 at much lower doses that are used in chemotherapy 鈥 while also protecting the heart. So the exosome therapy could help cancer patients without the severe side effects of chemotherapy.

鈥淭hese therapies can work hand-in-hand,鈥 Singla said. 鈥淭hey can treat cancer and protect the heart.鈥

Financial Investment is Key for Drug Development

The next step will be manufacturing the therapy for clinical use and advancing into FDA clinical trials for heart disease and cancer treatment. To help accelerate that path, Singla partnered with Orlando investor and 麻豆原创 donor Chakri Toleti, a healthcare technology entrepreneur focused on building category-defining businesses through AI and agentic platforms, biomedical innovation and ambient intelligence including most recently care.ai, which was acquired by Stryker in 2024.

Through his innovation fund, TCapital, Toleti backs transformative technologies designed to improve healthcare delivery and reduce human suffering at scale. Together, Singla and Toleti invested in and formed Exomic to fund continued research, clinical development, and commercialization of the technology.

鈥淭his was an opportunity to do something truly innovative in cancer and cardiovascular treatment.鈥 鈥 Chakri Toleti, 麻豆原创 donor

Toleti says his passion for advancing cancer research is deeply personal after losing his father to the disease.

鈥淭his was an opportunity to do something truly innovative in cancer and cardiovascular treatment,鈥 he says. 鈥淒r. Singla鈥檚 work represents a fundamental shift toward new biomedical platforms not only in how targeted therapies are delivered in the human body, but in how we think about treatment and healing itself.鈥

Such public-private partnerships are one of the goals of , which drives innovation, enterprise, and collaboration across disciplines.

鈥淒r. Singla鈥檚 groundbreaking exosome delivery system perfectly exemplifies how university innovation translates into significant, life-saving benefits for society,鈥 says Winston V. Schoenfeld, vice president for research and innovation. 鈥淎s demonstrated by the creation of Exomic, industry partnership is essential for driving such pioneering technologies towards successful translation and real-world clinical use.鈥

The effort is also providing exciting learning opportunities for College of Medicine graduate students. Jonatas De Mendonca Rolando 鈥23MS 鈥26PhD聽earned his Ph.D. in biomedical sciences earlier this month. He is staying at 麻豆原创 as a post-doctoral researcher to continue creating the exosome therapy.

He helped develop protocols and procedures for the delicate technology and saw its impact in the lab. He鈥檚 excited to have a financial supporter who can help take the therapy from lab to, he hopes, patients.

鈥淚t鈥檚 been amazing to part of a high-tech project and see leadership in science,鈥 he says. 鈥淚 am very excited for my future.鈥

Researcher Background

Singla is the AdventHealth Endowed Chair of Cardiovascular Sciences at the Burnett School of Biomedical Sciences and is a faculty fellow with the 麻豆原创 Office of Research. He earned his bachelor鈥檚 and master鈥檚 degrees from Punjabi University, Patiala, India, and his Ph.D. from the Post Graduate Institute of Medical Education and Research, Chandigarh, India. He has published more than 100 peer-reviewed papers and has continually been funded by the American Heart Association and/or the National Institutes of Health since 2004.

About TCapital

TCapital is an AI, Frontier Tech and Life Sciences innovation fund investing in category-defining platforms and infrastructure. Founded by healthcare technology entrepreneur Chakri Toleti, T-Capital invests in companies shaping the future of treatment, care, and biomedical innovation. For more information, visit TCapital.com.

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Dr. Singla and team From left to right: Research Scientist Chanderkala Aluganthi, Jonatas Rolando, now a 麻豆原创 post-doc, 麻豆原创 graduate student Omonzejie Imaralu 鈥22MS, Singla and Chakri Toleti