For generations, scientists have looked to the genetics inside immune cells for ways to improve how the body fights disease.

Now, a research team led by 麻豆原创 College of Medicine assistant professor Hung Nguyen is examining an understudied molecule within T cells as a pathway to treatments for cancers, infections and autoimmune disorders.

Their study, recently published in Trends Open, focuses on transfer RNA (tRNA), molecules within cells that help build proteins to energize themselves. Nguyen is working to chemically modify these molecules to expand the function of T cells, specialized white blood cells that are the cornerstone of the body鈥檚 immunity. The findings represent an important first step toward understanding whether tRNA can eventually be manipulated to fine-tune immune responses to multiple diseases.

T cells play a key role in identifying and killing invasive abnormalities within the body, including infections and cancers. The cells also allow the body to remember previous infections and respond more quickly if re-infected or attacked, says Cuong Pham, a biomedical sciences Ph.D. candidate working under Nguyen who served as the study鈥檚 first author.

鈥淭 cells are already central to modern medicine,鈥� Pham says. 鈥淎t the same time, we still do not fully understand all the molecular mechanisms that determine how T cells become activated to respond. Our review brings together emerging evidence showing that tRNA modifications can help support and regulate these responses.鈥�

This discovery comes as a continuation of Nguyen鈥檚 efforts to find innovative immunotherapies for a wide range of conditions. An early career researcher, Nguyen earned a 鈥淩each for the Stars鈥� award from 麻豆原创 in 2024 for his potential for significant impact.

An Innovative Approach to Immunity

麻豆原创鈥檚 research is the first time scientists have tested modifying mitochondrial tRNA in T cells to change their behavior, Nguyen says.

鈥淲e are looking at the tRNA modification within T cells that have never been reported,鈥� he says. 鈥淚n the field, tRNA modification is not so new. For T cells, researchers have been focusing on all the other parts before now.鈥�

The discovery came as a result of an active project in Nguyen鈥檚 lab that is examining how diet can affect the immune response in聽 cancer patients.

鈥淚 wouldn鈥檛 say we found this by accident, but we were very lucky,鈥� Nguyen says. 鈥淲e examined the mitochondria of the T cell, and we kept looking at all the different layers and targets and then we arrived at the tRNA.鈥�

Studying tRNA is challenging because the molecules are short and densely packed, making them difficult to analyze and modify, Nguyen says.

So the 麻豆原创 team used cutting edge technology called liquid chromatography-tandem mass spectrometry (LC-MS/MS). The highly sensitive technique separates massive quantities of molecules in a sample and then identifies and measures them.

鈥淚t is very new for use in detecting tRNA, and it was so important for us to see how everything worked,鈥� Nguyen says.

Results Could Impact Other Immunity Research

In the study, the team genetically engineered the tRNA to give T cells signals to activate against specific disease cells.

While the research is still in its early stages, Nguyen says that they have already identified ways to modify T cells to pinpoint and fight melanoma, colon cancer and lupus.

Nguyen says he hopes his new findings will provide a way for other researchers to create new immunotherapies.

鈥淲e want to share these ideas with the greater science community and bring everyone together to help us validate them and ultimately benefit more people,鈥� he says.

Drawn to 麻豆原创 for its opportunities for interdisciplinary research, Pham says he鈥檚 looking forward to being a part of what鈥檚 next in the College of Medicine鈥檚 immunology efforts.

鈥淭he next step is to move deeper into the mechanisms behind these observations,鈥� Pham says. 鈥淥ur lab has strong and ambitious research directions in immunometabolism. We want to understand how those changes in tRNA influence T cell metabolism and function, and whether specific pathways can eventually be targeted to ultimately help patients.鈥�

Minh Tuyet Le Nguyen, a 麻豆原创 postdoctoral scholar, and the Hanoi University of Pharmacy in Vietnam also contributed to the research.

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R01HL166820. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

The Reach for the Stars awards highlight their contributions to academia and underscore 麻豆原创’s commitment to fostering groundbreaking research. The prestigious award for early-career faculty is second only to Pegasus Professor as 麻豆原创鈥檚 highest faculty honor. Awardees receive a $10,000 annual research grant for three years.

The 麻豆原创 community is invited to congratulate the recipients and other faculty being recognized for teaching, research and service from 3 to 5 p.m. on Wednesday, April 3, in the Pegasus Ballroom of the Student Union as part of the聽annual Founders鈥� Day聽Faculty Honors Celebration.

This year鈥檚 Reach for the Stars honorees are:

Vasileios Anagnostopoulos

• Assistant professor at and director of 麻豆原创 Nuclear Regulatory Commission Fellowships.
• Ph.D. in chemistry from the University of Patras.

Vasileios Anagnostopoulos鈥� research helps to fuel the future.

As a nuclear chemist, his research encompasses radioactive waste management, environmental radiochemistry and nuclear forensics as it pertains to nuclear energy and nuclear forensics for aiding national security.

鈥淚n my group we study containment technologies for safe radioactive waste management and the environmental impact in case of leakages or accidents, as well as the properties of nuclear materials in the context of nuclear security,鈥� Anagnostopoulos says.

He aspires to make his vision a reality by ensuring it is safer and more accessible.

In 2023, by leading one of the areas of a $25 million consortium funded by the National Nuclear Security Agency in addition to securing a grant from the U.S. Nuclear Regulatory Commission.

Before he came to 麻豆原创, Anagnostopoulos鈥� interest in nuclear chemistry was ignited after taking a course in radiochemistry at the University of Patras in Greece. It solidified his desire to delve deeper, pursue his Ph.D. and continue his research at 麻豆原创.

鈥淚 was so pleasantly surprised by the positive spirit of the people, the warm welcome of fellow faculty in chemistry and the beautiful campus,鈥� Anagnostopoulos says of his first impression of 麻豆原创. 鈥淎s years passed by, I appreciated on a day-to-day basis the support of my colleagues and the talent among the student body.鈥�

鈥淢y group鈥檚 research is directly contributing to societal well-being by supporting nuclear energy cycle鈥檚 back end, that of environmental radiochemistry,鈥� he says. 鈥淣uclear forensics is contributing to a safer future at a global level, where nuclear materials follow the established legal processes and uses.鈥�

Positioning the United States as an authority on nuclear energy is a goal he hopes to achieve by advancing his research and collaborating with his government stakeholders.

鈥淢y research is effectively addressing the national demand for proficient nuclear chemists, which is a component critical to keep the U.S. in the forefront of global development in the field,鈥� he says.

Being one of the honorees to receive a 2024 Reach for the Stars award is a testament to both Anagnostopoulos鈥� research and the academic 麻豆原创 community supporting him.

鈥淭his recognition serves as a powerful motivator to push the boundaries of my research in nuclear chemistry,鈥� he says. 鈥淚’m incredibly grateful to 麻豆原创 for fostering a thriving research environment, encouraging thinking outside of the box and recognizing early-career scientists through awards like the Reach for the Stars. This award is a shared accomplishment, and I’d like to dedicate it to my research team 鈥� they are the future of this field.鈥�

Achieving new breakthroughs in nuclear energy research is exciting for Anagnostopoulos, but knowing he鈥檚 inspiring and supporting the next generation of nuclear chemists is just as exciting.

鈥淲itnessing the success of my students is one of the most rewarding aspects of my job,鈥� he says. 鈥淢y role as a mentor is to guide them through the research process, foster critical thinking skills and prepare them for future success. Seeing them thrive is truly gratifying.鈥�

Anagnostopoulos is poised to continue discovering ways to better understand and refine clean nuclear energy while establishing nuclear safeguards.

鈥淭his has been a thriving environment that has allowed me to make an impact with my research and teaching,鈥� he says. 鈥淏eing part of 麻豆原创 was clearly meant to be and it is one of the best decisions I have made.鈥�

Lauren Bislick Wilson

• Assistant professor at 麻豆原创鈥檚 , interim director of the聽, and director of 麻豆原创鈥檚聽.
• Ph.D. in speech and hearing sciences from the University of Washington.

Through her compassionate research, Lauren Bislick Wilson helps people regain their speech and language abilities.

Bislick is a clinical speech-language pathologist and researcher who works with people who have suffered the loss of speech and/or language due to neurological injury.

She has dedicated her research efforts to diagnosing, treating and ultimately improving the quality of life of those living with communication disorders, such as aphasia and apraxia of speech.

鈥淧eople with post-stroke aphasia and apraxia of speech can improve with behavioral intervention; however, rehabilitation of speech and language abilities is not like healing a broken limb; it takes a lot of time, repetition, and ongoing intensive practice,鈥� Bislick says. 鈥淭he speech and language impairments that result from neurological injury have a significant impact on the lives of survivors and the people who love them. It is life changing.鈥�

The National Institutes of Health recently funded Bislick鈥檚 latest research to explore the efficacy of a home practice protocol for patients with apraxia of speech and aphasia. The data gained from this study will support future funding to extend the home-practice motor imagery protocol to even more patients with acquired communication impairments resulting from stroke and other neurological injury, she says.

The home-practice program is paired with an in-person, evidence-based behavioral treatment for apraxia of speech, called sound production treatment. The home-practice program presents the sounds and images of target words, prompting the patient to imagine speaking each word in their mind. In previous studies, motor imagery practice has shown to help rehabilitation by engaging neural networks that support motor execution 鈥� including those involved in speech 鈥� priming the brain for the physical act. The goal of this work is that the home-practice program, when paired with traditional speech-therapy, will bolster treatment outcomes.

There remains a large gap between what works in a sterilized and highly controlled lab setting and what can actually be carried out in clinical practice to support the rehabilitation of persons living with a neurogenic communication disorder, she says.

Bislick鈥檚 research is aimed at closing that gap.

鈥淢any of the evidence-based treatment protocols we have available to us were created in a laboratory setting and are not as accessible in clinical practice,鈥� she says 鈥淚 aspire to develop effective treatment programs that will improve survivors speech and language abilities and are clinically implementable 鈥� my hope is that the development of the home-practice program will be something that both clinicians and their clients will utilize and find beneficial.鈥�

Bislick鈥檚 NIH-funded research idea was created by a culmination of practices and remedies she had previously found to help patients improve their speech and language abilities, as well as psychosocial outcomes.

鈥淚 have examined variables that impact quality of life such as the benefits of mind-body practices like yoga on psychosocial outcomes and the development and maintenance of friendships post-stroke,鈥� she says.

麻豆原创 has fostered an environment where she can continue her studies and help patients.

鈥溌槎乖粹�檚 vision for growing and strengthening the research trajectory of the university was appealing,鈥� Bislick says.

She even collaborated with a yoga therapist and other researchers resulting in a modified yoga program for patients with aphasia that has been implemented across the United States and in Bermuda. Bislick is working alongside rehabilitation professionals at Orlando Health to implement the program via their in-patient rehabilitation program.

She is also working with Brooks Rehabilitation Center to create a specialized motor speech center to provide specialized training to speech-language pathologists and help patients with apraxia of speech and other acquired motor speech disorders. An educational and research arm will be a crucial part of the center and will support the next generation of clinical speech-language pathologists.

Bislick鈥檚 track record for pioneering research and patient compassion earned her the position of currently leading the 麻豆原创 Aphasia House. She works closely with instructors, staff and graduate students to help adults living with aphasia.

Although she鈥檚 already achieved much, the people living with aphasia and apraxia of speech remain on the forefront of her mind and Bislick knows her work is not yet done.

She hopes to continue her work and inspire the next generation of researchers along the way.

鈥淚 am grateful to my university for supporting me as an early career researcher, and I鈥檓 grateful to my colleagues, collaborators, students, patients and their families,鈥� Bislick says. 鈥淚 hope that my work and the work of my students and collaborators will help people with acquired aphasia, apraxia of speech, and their families live well with their communication differences.鈥�

Chlo毛 Rae Spencer

• Assistant professor of theater history and dramaturgy at .
• Ph.D. in theater and performance from the Graduate Center at the City of New York.

Dramaturg Chlo毛 Rae Spencer perceives the world as a stage and the stage as a reflection of the world around us.

Her sustained interdisciplinary research bridges immersive theater, performance studies, American history and dramaturgy 鈥� the practice of analyzing and interpreting plays for effective theatrical representation and reception.

Spencer鈥檚 research focuses on how the pairing of alcohol and immersive storytelling combine to influence audience participation at key moments throughout American theater history.

The goal is to contextualize how consuming alcohol and theatrical performance have impacted each other, which illuminates deeper truths about the evolution of American cultural identities.

鈥淭heater is often framed as an aesthetic thing to be consumed or critiqued, but my work on immersive performance challenges this paradigm by examining theater as a lived experience shared by communities, where audiences can co-create and actively shape their experience,鈥� she says. 鈥淏y investigating the historical and contemporary impact of drinking on performance, my work reveals broader cultural shifts and societal norms.鈥�

Theatrical performance is tightly woven into the fabric of humanity, and this interconnection persists throughout history and into today, Spencer says.

For example, Prohibition-era venues may have endured regular police raids while others may have enjoyed lax enforcement from corrupt law enforcement, and that had a cultural impact on which performance practices were allowed to thrive.

鈥淔rom the kitschy exotica of midcentury tiki bars to the performances of 19th-century concert saloon waitresses, I explore the fascinating interplay between people, libations and the art of performance,鈥� Spencer says.

She became inspired early in her career after discovering that Dionysus, the Greek god of theater, also was the deity that represented wine and revelry. Since then, her interest continued to grow as it led her to 麻豆原创.

Her role at 麻豆原创 as an instructor to aspiring artists and dramaturges is special, she says.

鈥淭he students at 麻豆原创 are a major inspiration,鈥� Spencer says. 鈥淲hether they鈥檙e theater majors dedicated to honing their craft or students from other disciplines who discover the power of storytelling and the immense effort that goes into creating live performances, 麻豆原创 students motivate me to come to work every day.鈥�

Spencer is particularly proud of the collaborative work she did with her mentor, Pegasus Professor for 麻豆原创鈥檚 production of Metamorphoses in November 2023. The show adapts a selection of Ovid鈥檚 ancient myths, staging them in and around a large pool of water in the center of the stage. Her role as a co-dramaturg (alongside 麻豆原创 graduate student Caroline Hull) was to contextualize the gods, legend聽 and historical events referenced in the text.

Spencer鈥檚 research and exposure led her to publish her findings in a book titled America Under the Influence. It combines archival research with firsthand accounts of immersive spaces while demonstrating how social drinking and performance can represent many different aspects of American culture.

Her continued involvement is propelling her to further explore the intricacies of performing arts and set the stage for her students.

鈥淚 am grateful that 麻豆原创 recognizes the value of creative practice as research,鈥� Spencer says. 鈥淏eing awarded the Reach for the Stars award validates not just my efforts as a theater researcher but also the impactful research being done by my fellow theater artist-scholars, not just in our department here at 麻豆原创 but across the broader field of the performing arts.鈥�

Hung Nguyen

• Assistant professor at 麻豆原创鈥檚 College of Medicine and head of Hung Nguyen Lab at 麻豆原创鈥檚 Lake Nona Campus.
• Ph.D. in biochemistry from Chungnam National University.

Understanding how to treat nefarious diseases and better treat patients is central to Hung Nguyen鈥檚 research.

His team at 麻豆原创鈥檚 Academic Health Sciences campus in Lake Nona specifically studies T-cells 鈥� a special type of white blood cell that is crucial in aiding the immune system 鈥� and how they interact and combat diseases such as cancer, autoimmune diseases and COVID-19.

Nguyen鈥檚 accomplishments include and and infection rates.

鈥淥ur research not only provides novel knowledge of immunology of cancer, autoimmune disease and COVID-19, but also novel therapies and diagnostic analyses for those diseases,鈥� he says. 鈥淲e want to generate more and more therapies for patients.鈥�

Putting patients at the forefront is central to Nguyen鈥檚 research. His hope is to help those diagnosed with conditions that previously have had high mortality rates.

鈥淲e attempt to generate novel immunotherapies for saving patients鈥� lives,鈥� he says.

Nguyen starkly recalls the complexities of studying COVID-19 during the onset of the pandemic. He and his immunology team at the Burnett School of Biomedical Sciences studied how metabolic changes in the body affected immune response, with the goal of better predicting who is more susceptible to severe cases of the virus. Nguyen says he鈥檚 thankful to have been surrounded by so many close researcher who helped guide him through the challenges of both researching and navigating COVID-19.

鈥淚 feel deeply grateful to my family who provided me with uncountable support, and motivated me, particularly during COVID-19,鈥� he says. 鈥淚 am thankful for the hard work of my lab members, and I appreciate the kind advice of my collaborators and mentors. I particularly would like to also thank Dr. [Timothy] Gilbertson, with whom I have been collaborating since I first stepped onto 麻豆原创鈥檚 campus.鈥�

Earning recognition for outstanding research through the Reach for the Stars award is just as much his colleagues鈥� accomplishments as it is his, he says.

鈥淚t is not only for me,鈥� Nguyen says. 鈥淚t recognizes the effort of my entire team. I am proud of them for working hard to make the therapies we study come true.鈥�

The resources and backing from 麻豆原创 and his colleagues are crucial to Nguyen鈥檚 efforts to continue to study T-cells and develop life-saving therapies.

鈥溌槎乖� provides me with outstanding support to initiate and develop my scientific program in immunotherapy,鈥� he says.

Dazhong Wu

• Assistant professor at and director of the Additive Manufacturing and Intelligent Systems Lab at 麻豆原创.
• Ph.D. in mechanical engineering from Georgia Institute of Technology

Dazhong Wu and his team are transforming the way manufacturers use artificial intelligence to increase productivity and reduce costs.

At his , they work to develop real-time process monitoring solutions and machine learning models to prevent defects and errors as well as reveal complex process-structure-property relationships in additive manufacturing.

Additive manufacturing constructs 3D objects layer by layer. For example, 3D printing may be considered an additive manufacturing process.

Wu is working to study the convergence of additive manufacturing and artificial intelligence to make more intelligent and efficient systems that will ultimately make a difference in people鈥檚 lives.

鈥淚 hope to significantly improve efficiency, increase productivity, as well as reduce costs by integrating artificial intelligence, cloud computing and sensors with manufacturing machines and equipment,鈥� he says.

Wu鈥檚 aspirations are even more expansive. He鈥檚 also looking to accelerate economic growth for the industry.

鈥淢anufacturing is essential to the economy,鈥� he says. 鈥淓very dollar spent on manufacturing adds $2.74 to the U.S. economy, which is the highest multiplier effect of any economic sector.鈥�

Wu is particularly pleased of the great technical accomplishments he and his team have achieved. The integration of artificial intelligence into manufacturing processes and systems is an aspect of his manufacturing research that sets him apart from others in his field.

鈥淚 am very proud that my team developed novel data-driven predictive modeling techniques for predicting the complex mechanical behavior of additively manufactured materials such as composites and lattices,鈥� he says. 鈥淲e are also one of the first research groups that applied deep learning and physics-informed machine learning to solve quality control and process monitoring problems in the field of manufacturing,鈥�

Since joining 麻豆原创 in 2017, Wu has received great recognition in his emerging field. In 2021, he was honored as one of the and in 2023 was recognized as one of the top 2% of the most cited scientists in his field, as identified by Stanford University.

Earning a 2024 Reach for the Stars award reminds Wu of the support 麻豆原创 provides its promising young researchers.

鈥溌槎乖� is an academic leader in numerous fields such as mechanical and aerospace engineering,鈥� he says. 鈥淚 feel honored and privileged to be a recipient of the Reach for the Stars award. It鈥檚 also made me look back at what my team achieved, as well as reflect on how my research can make bigger societal impacts.鈥�

Treatments for blood cancers often require hematopoietic stem cell transplants but such cells can launch a potentially deadly immunological attack on the patient鈥檚 organs called graft-vs-host disease (GVHD).聽聽With the help of a $2.75 million grant from the National Institutes of Health, 麻豆原创 College of Medicine researcher Hung Nguyen is examining how diet 鈥� particularly fat 鈥� affects GVHD in transplant patients.

The disease comes in two forms. Acute GVHD usually occurs shortly after the transplant and can cause liver and digestive issues, a painful rash and even organ failure. Chronic GVHD can manifest months or years after the procedure. Symptoms vary among patients and can range from mild, such as dry eyes and fatigue, to irreversible organ damage. The condition can quickly advance from mild to severe in some chronic patients.

鈥淎lthough life expectancy for patients with these cancers has increased with the help of donor stem cell transplantation, it鈥檚 not without risk,鈥� says Nguyen. 鈥淲hen the donor cells perceive the recipients鈥� organs as foreign, chronic graft-versus-host disease develops.鈥�

Previous studies have shown that diets containing high levels of long chain fatty acids such as fat, olive oil, soybean oil, etc. have been known to increase infections, length of hospital stays, respiratory distress syndrome and systemic inflammation in GVHD patients. Because of that, Nguyen is taking a closer look at the role of fatty acids in inflammation and transplant rejection.

His team will study how medium chain fatty acid foods 鈥� such as coconut oil and avocados 鈥� affect the metabolism of donor cells of patients with chronic GVHD. He believes that a dietary approach to treatment could reduce or prevent the inflammatory reaction and lessen the patient鈥檚 need for corticosteroids, which have had limited success at preventing permanent organ damage.

鈥淭he goal of our current research project is to understand how medium chain fatty acid metabolism influences GVHD severity and mortality,鈥� he said.

Blood cancers make up about 10% of the nation鈥檚 diagnosed cancers each year.

Nguyen鈥檚 highly competitive R01 grant provides funding for five years from the NIH鈥檚 National Heart, Lung and Blood Institute. He is collaborating with Stephanie Lee at Fred Hutchinson Cancer Center, Seattle and Nosha Farhadfar at the University of Florida.