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In episode 10 of the 麻豆原创 podcast, Knights Do That, we speak with聽Annette Khaled, a 麻豆原创 professor and the head of the Division of Cancer Research at 麻豆原创. Khaled discusses her expertise on breast cancer research 鈥 specifically in breast cancer metastases. Khaled shares her personal experiences that drive the passion for her work, the collaborative culture of teamwork, optimism, and humanity at 麻豆原创, and some of the biggest mysteries of breast cancer that we鈥檙e still trying to solve.

Produced by 麻豆原创, the podcast highlights students, faculty, staff, administrators and alumni who do incredible things on campus, in the community and around the globe.

 

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Transcript

Annette Khaled: We need to do research to better understand what happens when we don鈥檛 catch cancer early, when a patient now has metastatic cancer that has spread, and can we develop better ways of helping these patients.

Because that鈥檚 where death occurs. Death and breast cancer are linked to the cancer spreading. So, understanding that process is essential for research.

Alex Cumming: Hey Knight Nation, what an interesting and enlightening conversation that I got to have with Dr. Annette Khaled from 麻豆原创鈥檚 College of Medicine. Dr. Khaled is the head of the Division of Cancer Research at 麻豆原创 and has been recognized for her breast cancer research specifically in breast cancer metastases. In today鈥檚 episode, we speak about the personal experiences that she鈥檚 had that drive the passion for her work, collaborative culture of teamwork, optimism, and humanity here at 麻豆原创, and some of the biggest mysteries of breast cancer that we鈥檙e still trying to solve. Let鈥檚 jump into.

So to begin, how did your interest with medicine, specifically working with breast cancer, develop?

Annette Khaled: Yeah, that鈥檚 a great question.

So my background 鈥 I鈥檓 a basic scientist. I really don鈥檛 work directly in medicine 鈥 I ask those basic biology questions. Why do things happen? Years back, I was working to understand how cells die. What causes a cell to die when it鈥檚 happily growing and suddenly all its growth signals go? What鈥檚 happening inside of that cell? And it really was in the process of understanding the molecular events that were happening in these dying cells that led us to discover what could potentially be a therapeutic for cancer. And that鈥檚 how we ended up now jumping into breast cancer and really working on both a therapeutic and a diagnostic for breast cancer. Moving from those basic discoveries to some application in medicine.

Alex Cumming: Wow. How cool?

So as of this year, the World Health Organization has found that breast cancer is the most common cancer globally. Can you share with me some of the importance of early screenings for breast cancer, as well as the need for continuous research of the disease?

Annette Khaled: Both those aspects are tied together. So early screening – cannot emphasize enough the importance. Any cancer, especially breast cancer, if you find it early, when it鈥檚 still inside the breast, it’s still localized to one place in the breast, it鈥檚 much easier to treat. You can remove it surgically. You can treat it, and outcomes are like 90% or 99% survival. So early screening is essential.

And then, why do we have to do research? Well unfortunately, for some people, they don鈥檛 catch it early. Sometimes they catch it when it鈥檚 already showing symptoms and spreading. It may be in the liver, it may be in the brain and the bones. And at that point we don鈥檛 have enough of an understanding about how that happened, why that happened. So we need to do research to better understand what happens when we don鈥檛 catch it early, when a patient now has metastatic cancer that has spread. And then can we develop better ways of helping these patients. Because that鈥檚 when death occurs. Death and breast cancer are linked to that cancer spreading. So understanding that process is essential for research.

Alex Cumming: Are there things you can notice within somebody that maybe they should say to themselves, 鈥淚 should get checked because I鈥檓 having this symptom or I鈥檓 feeling this sort of lump or I am just feeling off.鈥

Annette Khaled: Cancer is hidden. Cancer is your own body. It鈥檚 your own tissues, doing bad stuff to you. And so it鈥檚 really hard to wait for symptoms. That鈥檚 why screening is much more important. You should be screening yourself. And there鈥檚 guidelines, you should be screening by a certain age, by a certain risk factors.

You can do genetic testing, but it鈥檚 only a portion of cancers that are linked to a genetic outcome. So from my perspective, and it鈥檚 my own personal opinion, I think early screening is the best way. Get your mammograms every year. When you鈥檙e due, get your mammograms. Don鈥檛 wait for the symptoms because sometimes when the symptoms show up, it鈥檚 too late.

Alex Cumming: That鈥檚 good to be proactive instead of being forced to be reactive, sort of getting ahead of the curve.

Annette Khaled: Exactly.

Alex Cumming: What you鈥檙e saying it sounds as though a lot of people are forced to enter that reactive phase due to maybe outside circumstances that prevented them from being proactive on the situation. And when you鈥檙e in that reactive phase, it sounds like you have go all in on focusing on how can I give myself the best opportunity to treat this. And it sounds like from what you鈥檙e saying is that a lot of people don鈥檛 go into this alone. They have these circles in these groups that support them and help them along the way.

And as mentioned, breast cancer is one of the most common cancers found globally, support to know that you鈥檙e not alone in this situation, you find that鈥檚 an important 鈥

Annette Khaled: And not to be 鈥 it鈥檚 scary, right? You get a cancer diagnosis. I have cancer. 鈥淲hat did I do? Why has this happened to me? Did I do something?鈥 Disease just happens sometimes. And having support, having an understanding that there are great therapies out there. The survival is so much better now than it was in the past for breast cancer. There鈥檚 lots of treatment options and just get the support you need. You鈥檙e not doing this alone. We have great support systems for breast cancer. So I鈥檓 glad you said that. We can do things if you have, unfortunately, that cancer diagnosis. There are many avenues available.

Alex Cumming: My grandmother is a breast cancer survivor, so breast cancer awareness is a very personal topic for me. Of course she had it, I鈥檓 so thankful that she survived, beat it. I was younger, so I wasn鈥檛 fully able to grasp how it affects somebody鈥檚 body, but I saw firsthand how it affects the lives of my own personal family and herself. I鈥檓 so thankful that she lives in Florida, so we鈥檙e able to visit her and to be there for her in this time. And I mean, there鈥檚 just this weight that comes off of just this collective of people when we found out that she had overcome it.

Annette Khaled: It鈥檚 beating it that gives you that, 鈥淲ow, this is not the end of my life. This is something that happened along my life.鈥 And that鈥檚 what drives the research as well, as being able to advance that. Hopefully to the point where your grandkids will no longer see cancer as a threat. Cancer happens, there鈥檚 treatments. It goes away, we鈥檙e done. And hopefully take that threat from our lives.

Alex Cumming: When my grandmother was affected by it, she was in, I believe, late 60s, early 70s. And when she beat it she was in her mid, I believe, mid-70s. So, we have this joke, nothing鈥檚 going to keep her down. Nothing鈥檚 going to stop her from beating breast cancer in her 70s. It was a really just something that you don鈥檛 forget. You don鈥檛 forget that period of your life, where it was in the back of your head. We were like, 鈥淭his could be just any day, this could happen.鈥

Annette Khaled: So true.

Alex Cumming: So to transition from that, and that you spent nearly a decade studying ways to inhibit breast cancer metastases, which happens when cancer spreads to all other parts of the body. What have been some of the most important discoveries that you鈥檝e found?

Annette Khaled: I think the most important discovery we found, I was telling you earlier that we were studying this death pathway of cells and came up with a therapeutic. Trying to understand how, why the therapeutic was killing, really led us to discover a protein that hadn鈥檛 ever been associated with cancer before. And it鈥檚 a protein that helps other proteins fold – basically to get the right three-dimensional shape. Proteins have three-dimensional functionalities and so this protein that we found that our therapeutic was targeting was involved in this folding process. That had never been associated with cancer, and especially with metastatic cancer, like you said, the cancer that spread throughout the body. Really finding how this protein was working, how it was contributing to cancer spreading 聽– that has been probably one of the best discoveries that we have made in the last few years and really drives our research now.

Alex Cumming: Seeing that there鈥檚s these links between parts of the body and how they react when cancer is discovered in the body, is that what you’re saying?

Annette Khaled: Yes. So you think about cancer when it鈥檚 inside the breast, when it鈥檚 localized, has certain needs, right? , but once the cancer leaves its home in the breast and it travels and it goes through the blood. I mean, the stresses in the blood are horrendous. Most cancer cells die when they hit the bloodstream. But if they do survive, and those that survive need different survival factors than they did when they were in the home, in the breast. And then think of that, they have to now land in a new place, like they end up in the liver and the liver is very different from the breast, and it鈥檚 very different from the blood. They have to learn to adapt to that new environment. So the protein that we鈥檝e been studying, we think helps those cancer cells do exactly that 鈥 survive while they鈥檙e in the bloodstream, survive when they get to the new site in the liver to grow and colonize again.

That鈥檚 why it鈥檚 of interest to us. Because if what we鈥檙e discovering is true, then we do have a really great target as a therapeutic target for these types of metastatic cancers.

Alex Cumming: We spoke about the community aspect of this. Do you find the mental well-being of a patient can be akin to the medical wellbeing?

Annette Khaled: Oh, that is so true. I think just having hope. And I think that鈥檚 part of. I mean I really enjoy interacting and talking, like I am today with you, talking to anybody who interested in what we do. Because I think it gives people hope to know that my laboratory and all the other people in the cancer division, we鈥檙e all working hard on trying to find cures for cancer 鈥 that we have their back. We鈥檙e doing this because we want to be able to give them hope that maybe we can鈥檛 cure cancer today, but we鈥檙e working hard to find new discoveries that will lead to new treatments for cancer in the future.

Alex Cumming: I love what you鈥檙e saying about the hope and the optimism and to know every day students are waking up and going to places like 麻豆原创, where their focus is cancer research. And that there鈥檚 this generation of students worldwide who are working, again individual types of cancer, but that every day students are going and that cancer research departments are still prominent and are funded and are in a vital aspect of health departments at universities.

Annette Khaled: I love that you said that because that鈥檚 so true. Sometimes you forget because you鈥檙e taking classes and you鈥檝e got deadlines and you鈥檝e got to write your papers and your dissertation or whatever. But at the end of the day, what you鈥檙e doing is bringing hope to people.

It鈥檚 doing research that鈥檚 going to lead to new advances that one day, it may take five years, it may take 10 years, 20 years ,who knows how much it takes, but that someday you can say, 鈥淚 was part of that,鈥 or 鈥淚 was there when that happened, I was contributing to that process.鈥

Alex Cumming: What鈥檚 so nice, and this goes to most, all forms of medicine, is that a lot of these kids are doing it between the ages of 18 to [when they become] doctor, maybe mid-to-late 20s.

Annette Khaled: Or early 20s. Yeah.

Alex Cumming: Have their whole lives to work, to develop all these various research and treatments and it鈥檚 so cool. And to repeat what you said, hope, optimism.

On top of all your own research and your duties as a tenured professor, you鈥檙e also the head of the Division of Cancer Research here at 麻豆原创. What鈥檚 it like to oversee such an important division?

Annette Khaled: Oh that鈥檚 a lot to say in one sentence. I really enjoy working with people and being part of helping to lead the cancer division. There鈥檚 about, I want to say 11 or 12 researchers that fall under that division. It’s part of what I do every day. It鈥檚 not separate. I do my own research, but I also have that eye on the division as a whole to bring them together. So it really integrates very well with my current duties. I don鈥檛 see it as a separate thing, but it really falls alongside the things that I do every day. I teach students, I teach classes, I run my own lab. But part of that process is also keeping that global idea of how I can help my fellow colleagues in the cancer division also be successful. And so it鈥檚 all aligned together.

Alex Cumming: That you have to manage and understand what鈥檚 going on with everybody outside of yourself, but then also focusing on your own work, I can imagine that鈥檚 a lot to juggle at some times.

Annette Khaled: Well, like I said, it happens in parallel. We鈥檙e very collaborative. And so, as I said, it鈥檚 not really more work for me. It just aligns with the work that I currently do. The success in my lab extends to the division and the division successes feed back into mine. It鈥檚 become like a synergy. We鈥檙e all in it together. One person鈥檚 success is everybody鈥檚 success.

Alex Cumming: I love that. I imagine in a cancer research department egos are probably set aside and there鈥檚 not this competitive drive because one person鈥檚 success is everybody鈥檚 success.

I mean, in my own theatrical experience, yeah there鈥檚 egos every now and then. But it鈥檚 like, if you鈥檙e good for the show and the show was good, that鈥檚 on everybody.

Annette Khaled: Yeah, we鈥檙e a team. 聽Everybody鈥檚 doing their research and their thing, but cancer is very collaborative. It鈥檚 a field where you really lean a lot on each other. Everybody鈥檚 got an expertise, I don鈥檛 have to be the expert of every single thing. I can go to my colleagues and say, 鈥淚 want to do this experiment you鈥檝e done it in your lab. Can you help me do it in mine?鈥 And this is, the ideal situation you鈥檝e got this great team of folks that all have that joint vision of, yeah, we鈥檙e going to cure cancer one day. Not today, maybe, but down the road that鈥檚 our very ambitious goal. But we鈥檒l help each other today to do the things that we need to do.

Alex Cumming: It sounds like collaboration, teamwork and synergy are what helped you balance your responsibilities.

Annette Khaled: Exactly. You got it. Exactly.

Alex Cumming: That seems to be a running trend here at 麻豆原创. With all of the amazing people I鈥檝e had the pleasure to speak with, is that 麻豆原创 is just such a, and again this is not a new thought, but it鈥檚 just a great place for collaboration and teamwork are two of the big takeaways that you mentioned.

Everybody has their departments, but all the departments work together. And when all the departments are doing is great that just makes 麻豆原创 look great.

Annette Khaled: I don鈥檛 know if it鈥檚 just because of the way 鈥 we鈥檙e a young institution, right? In many ways, even biomedical research is barely a decade old, so we are still building our reputation. We鈥檙e building our credibility in the state. And that part of that helps us lean on each other more maybe than if we were in a nice established, fully funded institution with all the bells and whistles. Most people can thrive on their own better, but you know here we really rely on each other to help each other move forward.

Alex Cumming: That鈥檚 why I love this place. A moment ago, we spoke about my personal experience with breast cancer, how it affected my life in my younger years. Have you been able to meet families of breast cancer patients through your work?

Annette Khaled: Oh, yeah. I work with two very important organizations for breast cancer in the state of Florida and in Orlando. The Florida Breast Cancer Foundation is a fantastic organization of folks, breast cancer survivors, as well as researchers, doctors, all sorts of individuals, who are really focused to eliminate breast cancer for the state of Florida. And so I鈥檝e been working with that organization for a number of years and really get a chance to interact with all these folks 鈥 as I said, breast cancer survivors, breast cancer advocates, for folks that go all the way to Tallahassee and just do their best to get funds to help breast cancer survivors and breast cancer patients in the state of Florida, researchers like myself. So that鈥檚 a great organization, the Florida Breast Cancer Foundation.

But I also work locally with the Orlando Sports Foundation and they鈥檙e also an organization that鈥檚 led by Alan Gooch, who was one of our first football coaches at 麻豆原创. He runs this fantastic foundation that is really trying to use sport and sport venues, like football, golf, even bowling, all these venues to drive awareness for breast cancer and fund breast cancer as well, generate funds for breast cancer. So working through that organization. I鈥檝e met great people who really have a big heart and want to make an impact in our community.

So, like I said, I鈥檓 really blessed to have those two organizations that I can interact with and meet people

Alex Cumming: You鈥檙e wearing the pink, most people won鈥檛 be able to see it, but we know wearing pink to signify, to recognize, to honor the work people have gone through and to recognize the hard work that still goes into breast cancer awareness. And to have individuals that promote breast cancer awareness is so special to see is. That this is not just underground, subculture. It is in the general, it is in the zeitgeist. Again, you run into individuals who have experiences with breast cancer, like myself. Most people would be totally unaware that affected me in my younger years. It鈥檚 not something that since then I often reflect, but it鈥檚 in my memories. And you run into people that you might not realize have had an experience, had a breast cancer scare, had a surgery to maybe remove a piece of themselves. And you don鈥檛 realize that wearing pink is so special because it just, it鈥檚 there, it exists. You want to recognize it, the pink bracelets that individuals wear. When you noticed it on somebody.

Annette Khaled: And it鈥檚 so true because it really says, 鈥淲e鈥檙e here, you鈥檙e not alone. This is not a fight you鈥檙e doing by yourself and you鈥檝e got all of us wearing pink because we all want to be part of that team, that big universal team that goes beyond Orlando beyond Florida.鈥 That really is a global team that works toward, supporting, and helping, and eliminating in the long run breast cancer.

Alex Cumming: From the families and the patients that you have met, what have you been able to learn?

Annette Khaled: Well, a lot of how they cope. I remember sitting at a lunch one day and talking to a lady who had breast cancer. She鈥檚 a survivor and she鈥檚 [been] taking treatments for decades that give her hot flashes. Now, you鈥檙e young, you鈥檙e a man, you don鈥檛 know how hot flashes affect women, but I’m going through that and I can tell you it鈥檚 miserable. And I cannot imagine dealing for the rest of my life with hot flashes, but she has to because of the treatments she鈥檚 getting. And I remember sitting there going like, “Gosh, I wish I could make a therapeutic this woman could take in place of what she鈥檚 taking right now and help her have a better quality of life so that she鈥檚 not living with these hot flashes.”

It鈥檚 just things like that. But I found, just interacting with people made me appreciate really how it鈥檚 not just surviving. 聽It鈥檚 about quality of life, and making sure that what I do in my laboratory and the therapeutics and diagnostics that we move forward are always about quality of life as well. We don鈥檛 want to put something out there that is going to make people sick more than they are from the cancer that they鈥檙e dealing with.

Alex Cumming: That鈥檚 so special. To touch back on to the young students working to cure breast cancer, everybody has maybe their own motivations and their own stories of what inspires them, but it鈥檚 also this one larger goal.

Annette Khaled: Exactly. And I think it鈥檚 important. If I could just make one more plug here. I think it鈥檚 important that as a researcher, it doesn鈥檛 matter what discipline you鈥檙e working in 鈥 whether it鈥檚 infectious disease or neuroscience, whatever field you鈥檙e in 鈥 to always connect with the people, right. Connect with individual. You know that if you鈥檙e working in disease, Alzheimer鈥檚 connect with those. You鈥檙e working with infectious disease, connect with people, HIV, because that connection really brings your research home. It really helps you focus your research on things that are going to impact people, not just something that鈥檚 your own. Like you said, ego, right? It鈥檚 something that you鈥檙e doing to do that鈥檚 going to help the community. So I really love, not just for myself but also have my students connect with breast cancer survivors for that reason.

Alex Cumming: Humanity, that the individual in that room is not patient number 52. They are, John Doe from Longwood, Florida.

Annette Khaled: Exactly.

Alex Cumming: I have a personal experience with what you鈥檙e saying. My involvement at 麻豆原创 I鈥檓 with an organization called Playback 麻豆原创, which we began with our focus, it鈥檚 people tell stories and we鈥檒l present them back through an improvised form. And we started with students and of course, young college students have a lot of feelings. They feel things very strongly, and it was very special to perform back, to get to know my cohort better. But then we transitioned and we work indefinitely with the Aphasia House here in the 麻豆原创 area. And really the one-on-one experience of people who live life with aphasia it touches you in a way that you don鈥檛 expect going in. You might have an idea, but once you鈥檝e experienced it firsthand you don鈥檛 forget.

Annette Khaled: And I think it helps, put perspective to things. It really helps you say, 鈥淥kay, maybe what I was thinking wasn鈥檛 so bad. My own little problems in my own little world, I can give perspective to them.鈥

Alex Cumming: It does. It鈥檚 sort of, a humbling, but not in a humbling, 鈥淟ike, oh man, now I feel bad.鈥 It’s a humbling like, 鈥淲ow, I get to wake up every day and not worry about these sorts of things.鈥

Annette Khaled: And in value, when these individuals are waking up every day and they鈥檙e doing their lives and their things, and really the strengths that they have I always admire that tremendously.

Alex Cumming: Seriously to go back to another point, we have hope. The students have hope, but the individuals who are living with this day to day, their hope is what I want to believe. Their hope is what inspires the hope of the younger generations to continue to work. Because when they get afflicted by it, they don鈥檛, sit down and say, 鈥淲ell, let me count down the clock.鈥 It鈥檚, 鈥淣o, I know that somebody is working for me. There鈥檚 somebody out there who has me on their mind.鈥

Annette Khaled: And getting to a point you addressed earlier about your patient鈥檚 point of view and individuals鈥 hope and point of view, your mental wellbeing. If you have hope that whatever treatments, whatever therapy, whatever you鈥檙e going through, you have a chance of doing better because your mental wellbeing is healthy. Right?

And so that鈥檚 why it鈥檚 so critical not just to have the treatments and then whatever you鈥檙e supposed to do, your doctor tells you is critical to do, but also along those same lines, you have the hope, you have the mental wellbeing because those two together 鈥 the treatments and the mental wellbeing 鈥 is what鈥檚 going to lead to ultimately a treatment outcome, a success.

Alex Cumming: I love it. Do you have any other experiences or stories that keep yourself inspired?

Annette Khaled: Oh, there鈥檚 so many of them. I have to pick and choose.

Alex Cumming: Any highlights?

Annette Khaled: It鈥檚 really just being a survivor, and then not knowing if a cancer鈥檚 going to come back. And that鈥檚 the other big thing is 鈥 somebody tells me, 鈥淚 had breast cancer 20 years ago and then it came back and now it鈥檚 metastatic. And now I have five years, survival is really bad at this point, it鈥檚 20% or less.鈥 So it just talking to patients who have metastatic cancer and the way that they know they have almost a death sentence on their heads and yet they still have the hope, still have that enthusiasm. I鈥檓 going to be here for my grandkids. I鈥檓 going to be here for my daughter鈥檚 wedding. So many of those stores really inspire me and say, what we do every day. What we wake up in the morning, go to the lab, go to work, go to school, whatever we鈥檙e doing, thinking of those people is really what drives a lot of that for me

Alex Cumming: Humanity, the one common that we all have, we鈥檙e all humans.

Annette Khaled: Yep. When you鈥檙e faced with a crisis like that humanity is even stronger. It comes out more.

Alex Cumming: So I want to move on to this next question of what are some of the biggest mysteries of breast cancer that we’re still trying to solve?

Annette Khaled: It comes back to what I was telling you, cancer recurrence, why after you鈥檝e had treatment and the cancer was removed and you got all this therapy and you were given a clean bill of health 鈥 and then whammo five, 10, 20 years later, it comes back. We really do not know why, what changed. And a lot of times when it comes back, the treatments that work the first time don鈥檛 work anymore. It really is a real challenge for physicians to know what to do for these patients. So that鈥檚 one. And then the other one is the last few years immunotherapy, that鈥檚 basically taking your body鈥檚 immune system and turning it on so it can kill cancer cells, has really been an exciting new research and therapeutic direction and great successes for patients. But it doesn鈥檛 work for all patients. In fact, it works for maybe under 30% of patients. When it does work it鈥檚 amazing, it鈥檚 a cure, but why doesn鈥檛 it work for everybody? That鈥檚 the other big question. Why can鈥檛 we get this immunotherapy that has been so successful in this group of patients to work for everybody? How can a doctor know, do I give my patient immunotherapy or not?

Those are kind of the two big things for me, is that, why does cancer come back and then how do we figure out to give the patients their best treatments?

Alex Cumming: Those are both two things that are, what a wild thing to think about. So what advice would you give to somebody who wants to do what you do?

Annette Khaled: Oh, you have to have a passion for it. Doing research is not something that you can just open the door and do. I think you really have to have a passion and a love for discovery and have a thick skin that you can put up with disappointment and struggle and the negative parts of it. But always have that passion for discovery and know that those moments when you have that, 鈥淎ha, well we just discovered something really cool.鈥 To be able to live for those moments and enjoy them. So I can say it鈥檚 a vocation almost to do research.

Alex Cumming:

Annette Khaled: Yes, endurance, lots of things that go with it 鈥 and surprisingly optimism. I think you also have to have an optimistic mind frame because if you鈥檙e pessimistic and you look always at the hole and not the donut, you鈥檙e going to struggle. I think having a little bit of optimism is always good.

Alex Cumming: Yeah. I believe that translates to most everything that people do. Is there a profession you can have where you can just be a pessimist? If you鈥檙e like a critic?

Annette Khaled: Yeah, you can be a critic. I think there鈥檚 some professions that work well with that, but I would say definitely in ours, because we have so much pessimism and there鈥檚 so much negativity sometimes associated with doing medical research that I think, every little bit of optimism you can bring to it is important.

Alex Cumming: Totally. So what鈥檚 one thing that you’re still hoping to do here at 麻豆原创, and then on a personal level?

Annette Khaled: Actually those two things are tied together. We鈥檙e building a new cancer center and this has been something that鈥檚 been in the works for now going on three years. I鈥檓 hoping to be able to be part of the process that we build our cancer center and hopefully make it a place that鈥檚 not only a place for students, a place for professors, like myself, to do research, a place for patients to come and get cutting-edge therapies. Really a place where all that鈥檚 integrated, where we really have a flow of knowledge from all these levels of students, to professors, to patients, to doctors, to everybody involved in treating a cancer patient.

So really it鈥檚 ambitious, but I do see hope one day that we can be sitting here maybe 10 years down the road and saying, 鈥淵eah, that Lake Nona Cancer Center that鈥檚 one of the top 10 cancer centers in the country for everybody to come to.鈥

Alex Cumming: I鈥檓 looking forward to it. I love the sound of a place where just knowledge healing growth is all just wrapped into one, based out of here in central Florida.

Annette Khaled: And has that unique 麻豆原创 culture, right? We were talking about earlier that collaborative culture that infuses our cancer system.

Alex Cumming: True that. I think everything we spoke about today can be found at 麻豆原创, the collaboration, the teamwork, the optimism, the growth for the future, the humanity, it鈥檚 all here at 麻豆原创.

So Annette, I want to say thank you so much for speaking with me today. loved our conversation. Thank you for letting me speak about my own personal experiences and for sharing your own experiences. It鈥檚 been such a pleasure to get to learn more about something that I’m aware of, I have memories of, but to dive a little deeper into it. To get a better understanding of it. So it鈥檚 been a pleasure to get to speak with you and thank you for coming on.

Annette Khaled: Well, thank you for asking me. I really enjoyed it. And I’m so happy to hear about your grandmother.

Alex Cumming: She鈥檚 still here. I’m certain she鈥檒l love this episode.

Annette Khaled: Wish her well for me.

Alex Cumming: I certainly shall. Thank you.

Annette Khaled: Okay. Thank you. Take care.

Alex Cumming: Hey, thanks for listening. I鈥檒l see you, you, on the next episode of the Kights Do That podcast. If you鈥檙e doing something cool, whether that鈥檚 at 麻豆原创 or somewhere, you took 麻豆原创 that we should know about. Send us an email socialmedia@ucf.edu, and maybe we鈥檒l see you on an episode in the future. Go Knights and Charge On.

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麻豆原创 Podcast: An Insider Scoop on 麻豆原创 Athletics /news/an-insider-scoop-on-ucf-athletics-podcast/ Mon, 23 Aug 2021 13:06:28 +0000 /news/?p=122397 The Voice of 麻豆原创 Athletics, Marc Daniels, joins the podcast to talk about the sports scene in Orlando, preview the upcoming football season and share his expertise as a broadcaster.

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In this week鈥檚 episode of the 麻豆原创 podcast, Knights Do That, we speak with Marc Daniels, longtime broadcaster of the 麻豆原创 Knights.

One of the area鈥檚 most recognized and respected media personalities, Daniels reminisces on his experiences and favorite memories of the last three decades, gives an insider look into some coaches and players, shares his expertise as a broadcaster and previews this season of 麻豆原创 Football under new head coach Gus Malzahn.

Produced by 麻豆原创, the podcast highlights students, faculty, staff, administrators and alumni who do incredible things on campus, in the community and around the globe.

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Marc Daniels jokes he is known more for car commercials than his longtime gig as the broadcaster for the 麻豆原创 Knights. (Photo by Brandon Brown ’18)

Transcript

Marc Daniels: I think that鈥檚 one of the biggest advantages that we have is that we鈥檙e still writing our history while others are kind of upholding a history.

And that鈥檚 why I think this is the best time at 麻豆原创. There鈥檚 still so many amazing things that are out there.

Alex Cumming: Wow. Knight Nation. I am so excited for y鈥檃ll to listen to this episode of Knights Do That. To me, it鈥檚 like music to my ears, hearing the Voice of 麻豆原创 鈥 yeah, that鈥檚 right. Today we have Marc Daniels, the Voice of 麻豆原创 Athletics. He鈥檚 sharing his experiences with 麻豆原创 Athletics for 27 years now 鈥 from the early memories and how he got started in broadcasting to sharing some of his favorite moments at 麻豆原创, like his iconic call for a in 2017.

And after all the reminiscing on 麻豆原创 football and basketball, we get into looking ahead to this season of 麻豆原创 football with Coach Malzahn and some of his predictions for the season. Knights, I hope you鈥檙e ready for this one.

Broadcasting at 麻豆原创, you鈥檝e been identified as like “The Voice of 麻豆原创.” The thing that people 鈥 I know for me, before meeting you personally here 鈥 I identify you. I know your voice. When I see it on television. When I hear it in commercials I鈥檓 like “There he is. That鈥檚 him.”

Marc Daniels: Yeah, that鈥檚 cool to be recognized as that.

I joke and say, “It鈥檚 the only skill I have, so I better be good at it.” No, I鈥檓 honored when people connect me and they hear my voice go, “Oh, 麻豆原创 and everything.” It鈥檚 a privilege to do what I do. So I鈥檓 honored when people come up and say, “Oh, I鈥檝e listened to you. Or, I went to school at 麻豆原创 and now my son or daughter goes to 麻豆原创.” I love that. It means a lot to me. So I鈥檓 grateful when people do that. And I love doing what I do.

Alex Cumming: You鈥檙e checking out at the Publix. Do you have people say, “Do I know you from somewhere?”

Marc Daniels: Yeah. You鈥檙e the voice of every conversation or lately what I get is, “Are you the guy on TV?”

And I go, 鈥淵eah, I鈥檓 麻豆原创.” They go, “No, the guy selling cars and stuff.” Again, I鈥檓 honored by that. I think it鈥檚 fantastic. And yeah, I love to meet people that say they appreciate your work.

Alex Cumming: I watch a lot of late night television, like talk shows, so you鈥檙e always the lead in into it. And I鈥檓 like, “There he is. That鈥檚 the guy.” Like SNL is about to be on and you show up before it.

Marc Daniels: It鈥檚 incredible. You work 30 years at a market and someone goes, “Yeah, they know you for a 15-second TV commercial.” But that鈥檚 okay. That鈥檚 good.

Alex Cumming: Hey, it鈥檚 better to be recognized for that for something else. So broadcasting, what got you into it?

What was the draw for you into the broadcasting world?

Marc Daniels: Well, like a lot of people my age growing up, I was supposed to play professional baseball or basketball or football. I was supposed to be one of those stars and I was really good at baseball and thought that would be the path for me, but I started working in radio when I was 14 and was fortunate to have that opportunity and enjoyed it a lot.

And then when I got injured playing baseball and realized that perhaps was not going to be an avenue, then I pursued that path. And when I went to college, continuef to advance in it and being involved in sports was great for me. And just thought that was a good path and was fortunate to get some great opportunities and some wonderful people that helped open some doors for me. And I made the most of it working in radio and TV.

Alex Cumming: It seems as though a lot of people, they maybe they have one idea, then they fall into another. One thing that we鈥檝e spoken a lot about on the podcast is the path can be uncertain, there are so many avenues that you can end at something that you find that speaks to me, sticks with me.

When did you realize that you were like, “Oh, I have this voice.”

Marc Daniels: I was working in a radio in high school and I had a few people in the business a long time that said, “That鈥檚 a pretty good voice that if you really want to make this a career, you got a chance to do that.”

So then when I went to college and started working in radio and television it felt like this could be something for me and the voice thing was going to work and it just grew from there. I had an incredible passion for sports and then when I got a chance to call games, which was always what I wanted to do. Once I felt like, okay, broadcasting is going to be a path and whether it was being a reporter or hosting a talk show, but then calling games and then just the rush of doing that became really something.

I said, “I want to see if I can make a career out of this.” And was fortunate to have some opportunities to develop.

Alex Cumming: It鈥檚 so interesting to see that, these things so young, these little things you dabble in and how they can just blossom.

Marc Daniels: Yeah. I grew up in a house where sports was so much a part of our life.

My dad played minor league baseball for a couple of years. And I was born in New York. Our family, big New York sports scene fans. So the Yankees and the Giants, the Rangers, the Knicks and everything, and grew up listening to baseball on a little A.M. Transistor radio. And I idolized my dad and my older brother, who unfortunately passed away years ago. In my house you had to know the starting lineup 鈥 not just of the Yankees, you had to know of the names and numbers of almost every player in Major League Baseball. My brother would quiz me and go, “Okay, here鈥檚 the box score. Give me the 1974 lineup for the Chicago Cubs.鈥 And I was 7 and I think I knew it.

So that鈥檚 where that passion came from. And then when you listen to games, cause now I鈥檓 going back to when ESPN didn鈥檛 exist. So there was like one baseball game a week on TV that I got to watch. So you grew up listening to people call games and those magical voices at a time that A.M. radio was the thing. And you could be in New York and possibly pick up WGN in Chicago and hear a Cubs game or KMOX in St. Louis and hear the Cardinals.

And I think that鈥檚 where it began to develop. And as I got older and our family moved to Florida, I still loved the concept of perhaps getting involved in broadcasting. So I, like a lot of kids, you do mock games. You pretend, you鈥檙e at the plate and you hit that game-winning home run. So I guess that鈥檚 the roots of it.

Alex Cumming: I bet that transferred over really well, memorizing all those cause then you have to memorize baseball, men鈥檚 soccer, women鈥檚 soccer, volleyball, football 鈥 of all the players here at 麻豆原创 and the major names within the conference NCAA sports as a whole to be familiar with the name that somebody throws out to you.

Marc Daniels: Yeah. Every sport is unique in the way you broadcast it. And there鈥檚 a certain I think presentation you strive for. Like football broadcasts for about six, six and a half hours. Basketball is different because it鈥檚 a faster pace. Baseball鈥檚 a storytelling sport because there鈥檚 so little action in the course of what could be a three, three and a half hour game. So you鈥檙e sharing stories, whether it鈥檚 about the players or about your life and things that you connect with eliciting audience.

So every sport鈥檚 unique and the way I prepare for broadcasts may be completely different than somebody else. And there鈥檚 no right or wrong way. It鈥檚 just diving into the event 鈥 it really is a production and everyone鈥檚 unique.

Alex Cumming: Yeah, definitely. So when you came to Orlando in 1989, which was a big year for Orlando sports. Orlando Magic right then, and then headed into that decade, 麻豆原创 football became larger and larger. The Magic, you know with Shaquille O鈥橬eal, Penny Hardaway, their playoff run in the mid 鈥90s.

Marc Daniels: Didn鈥檛 the World Cup come here in 鈥94?

Alex Cumming: That鈥檚 right. The World Cup. Wow. And the Olympics are right up in Atlanta right?

Marc Daniels: 鈥96 in Atlanta. But we had Olympic soccer in Orlando.

Alex Cumming: That鈥檚 right. Wild. But during that, you鈥檙e here and you鈥檙e working to create one of Orlando鈥檚 first all sports stations. What can you tell me about those days? Remember going back to there, getting it off the ground.

Marc Daniels: I moved to Orlando in May of 鈥89. Really taking a gamble. There was a job offer to me at a company called Florida Radio Network, which was just that. It was radio department that was distributing news and sports and features to affiliates around the state. And there was an opening to work in sports. But I came up here, I did some sports updates. I did news and a whole bunch of other things. And I took the job for $13,600 and it was just, okay, we鈥檙e going to go do something, let鈥檚 go do it. Came up here with very little and didn鈥檛 make a lot of money, but I had a blast and then was fortunate to have an opportunity to do the sports talk show that was on the local A.M. station.

And it was the summer before the Magic were going to start. And the guy that had been doing that show took a job in Washington and they gave me a one-month trial. And then when they said I was going forward they gave me $20 a show, and I thought an extra hundred bucks a week, I am living the big life.

And yeah, that was the year the Magic started, in that fall and Orlando, it was different today. Now that today鈥檚 worse. I鈥檓 just saying back then, when the Magic rolled out it was like, “Wow, there鈥檚 a pro sports team in this town.” There was a very unique connection with the fan base and the expansion team.

And then to be able to get Shaq, and then Penny, it was special cause it happened so quickly. But every home game was a big event. Going downtown if you went to the Magic game and then you went out afterward, or even before to get dinner, it was a big event 鈥 win or lose. Cause it was just, wow.

Michael Jordan, Larry Bird, Magic Johnson, they鈥檙e coming to Orlando. That was a really big deal. And that was a fun, fun time in Orlando. And there was 麻豆原创, that was that football program and that athletic program and that university, that was nice, but it was the commuter school.

When I came here to everybody said, “Oh, that鈥檚 a nice little commuter school.” I think when I came here, I think enrollment was like 16,000. And then when I started doing games in 鈥95, I think it was like maybe 22, 23. And people are like, “Oh that鈥檚 really big.” And now look where we are 鈥 聽over 70,000.

Alex Cumming: It鈥檚 beautiful to see the growth of it.

So when you鈥檙e here in Orlando, we have the Magic growing, 麻豆原创 growing, do you look down to Miami or to Tampa and you say, “They have scenes there that are established.” And you say, “I want to stick to Orlando to watch it grow and flourish and develop.” Which it has now 鈥 Orlando City, 麻豆原创 being this national brand here.

Marc Daniels: Yeah. Orlando was unique, as I said, because basketball was so new. And as somebody that moved to Florida, when I was 7 in 1974, you got to remember back then the Dolphins were new. That was it for pro sports. People didn鈥檛 follow pro sports, college sports was bigger.

The closest baseball team was the Braves in Atlanta. There was no NBA. And then things began to develop. Heck, when I grew up in South Florida the most popular baseball team was the University of Miami鈥檚 baseball team. When they won their first college world series, that was a major, not sports, that was a major news story. When they won their first national championship in football that was a big story. So I watched all these cities grow and as far as Orlando, the Magic kind of put it on the map. We became this international city that was known for more than just theme parks.

And all of a sudden you saw this sports explosion. I remember the bid process to get the World Cup here in 鈥94. It was a really big deal. When Orlando landed that people were like, “Wait a minute. What?” And it was a vision by a lot of people, the mayor back then, and the kind of sports commission that was in place then.

So it was a really big deal to watch it grow over those years to where now you see the success of Orlando City and obviously what 麻豆原创 has become. And it still has a chance to grow. I know the pro sports landscape, the way Tampa is aligned makes it maybe difficult to envision another pro team, but who knows. We鈥檒l see what the future holds, but it鈥檚 been fun in the 30 plus years I鈥檝e been here to watch it change.

Alex Cumming: Back in those early days, late 鈥80s headed into the early 鈥90s, what do you think was the success that you got this thing up off the ground and now seeing it flourish?

Marc Daniels: As far as the radio station?

Alex Cumming: Yeah. When you were there, what did you think was the success for that?

Marc Daniels: Radio was changing and the sports radio format exploded. It used to be that major cities had sports radio stations, and then it began to grow as a few networks popped up along the way. And the timing was right. I was one of several people that helped formulate the first all-sports station. We put it on the air in fact, on New Year鈥檚 Day. And we had some success early, some bumps along the road, but I think that there was a passion because Orlando is still is relatively unique. It鈥檚 a melting pot still have a lot of people, people like yourself, that were born here were unique in the sense, cause a lot of people came from New York, Chicago, Philadelphia, Boston and so forth that had moved here and it made it unique because if you were going to talk pro football, there are fans of the Steelers and Packers and Eagles and Giants and all sorts of things. And still today it鈥檚 the same way.

So I still think that was always unique about Orlando sports wise for college. The Gators were the dominant team, but again, when people moving from other places. You had Ohio State fans and Michigan fans and people like that. But now you fast forward with the growth of 麻豆原创. Now there鈥檚 a lot more black and gold around town.

Now there鈥檚 more Orlando City magnets on cars and things like that, which is great. It shows you how we鈥檝e evolved and how the market has grown. And you talk about TV market being a top 20 market, and probably the next decade, it will easily move inside the top 15. This is a major city.

Alex Cumming: Oh, yeah. Big time. A lot of it is very generational. You know like what I was saying with my parents and their experiences with the Magic. I have experiences with the Magic. When I was younger if you pass the FCAT you got a free ticket to the Dwight Howard era games. And I regret not going to more of those looking back then now, you know how it is.

I was just at the Amway the other night for the draft and it was fantastic.

You have yet to miss a 麻豆原创 game. Correct?

Marc Daniels: Are you jinxing me now? No, this will be year 27 and I鈥檝e done now over well, over 300 football games.

Alex Cumming: Respect for that. As I said, I have been, I remember the Citrus Bowl days headed on to, back at Bright House Stadium, headed onto what it is.

And I鈥檝e missed a game or two. As a student I鈥檝e been fortunate to go to a number. But in those, have you had any close calls where you鈥檙e like, “Maybe I won鈥檛 make it to this game?”

Marc Daniels: No. In football, I鈥檝e been fortunate from a schedule standpoint that nothing takes a priority over 麻豆原创 game day.

Travel wise, I don鈥檛 think we ever got to a point that it was like, “No we鈥檙e going to get there.” I do think over the years, I think there鈥檚 a couple of games that I did get to on a day of the game but it was never a race to get to the stadium for kickoff. So I鈥檝e been fortunate when it comes to football, and I broadcast again, I鈥檝e done two games in Hawaii. We鈥檝e played a regular season game in Hawaii and the bowl game in Hawaii. I went to Ireland for the game against Penn State. I鈥檓 fortunate between the football, basketball, baseball, and other events I鈥檝e done, I broadcasted over 250 campuses across the country. So I鈥檝e been in, some of the most iconic football stadiums at Penn State, Ohio State and Michigan and Alabama to some of the most scenic places.

Everybody should have BYU as a bucket list trip because it鈥檚 absolutely gorgeous to watch a game there. Stanford, New Mexico people may not think so, but the mountains are great. Ohio University in Athens, Ohio, is a beautiful stadium. So it鈥檚 not all the glitz and glamour of these major places. There鈥檚 some great campuses. There鈥檚 some that I don鈥檛 have a desire to get back to but for the most part, it鈥檚 great. I love the opportunity to go to a new place and broadcast.

Alex Cumming: And soon those people come to Orlando and they say you got a bucket list. Don鈥檛 just go to, Lake Buena Vista, go to Disney, and Sea World make sure you get out and see the city downtown.

Head out 鈥

Marc Daniels: And it never fails when people come for the first time to experience a game day at 麻豆原创. I used to play for years. I still do. And I play this game when I travel. People see the 麻豆原创 logo that I鈥檓 wearing and some will still go, “Oh, UFC.” And you鈥檙e like, “No, it鈥檚 麻豆原创.” And they go, “Oh yeah, I think I know them.” And I always play the game is, ” Do you know how big our school is? The enrollment .” And they鈥檙e like, yeah, “I think it鈥檚 pretty big.” and I usually set them up and go, “Florida is like 53,000. So how many you think 麻豆原创 is?” ” Oh, then it鈥檚 probably like 30.” And then when you go, “No it鈥檚 60 or 65 or 70.” Then they don鈥檛 believe you. Then they Google it and they go, “Oh, wow. I didn鈥檛 know that.”

And the same thing happens when people come and visit our campus on a game day and they didn鈥檛 realize that, “Oh, wow. I didn鈥檛 think this was going on.” From all the pregame tailgating and Memory Mall and the fans outside the stadium. And then inside into experience, when the team comes out and, moments before kickoff and things like that.

It鈥檚 great because they become walking billboards. When they鈥檒l go tell people, 鈥測ou won鈥檛 believe what it was like at that place,鈥 because until you experience it it鈥檚 hard to understand. And that鈥檚 great. It鈥檚 part of the growth of our brand. That鈥檚 still is the message being sent out there.

Alex Cumming: It鈥檚 an Orlando event. A 麻豆原创 game day is an Orlando event. Summer 2019, I was fortunate enough to get to visit Toronto and cities in Alaska, had a 麻豆原创 hoodie on. People said “麻豆原创.” People in Alaska. I met a bus driver in Alaska. He said, “Hey 麻豆原创, I have a friend who goes there. I know.”

Marc Daniels: Yeah. It鈥檚 funny and it鈥檚 a credit, like Dr. Cartwright has even acknowledged it as well, the importance of an athletic program to this huge university and everything that we have going for it. So many wonderful things and the growth of our campus is incredible. But sports can help with that growth. I was fortunate, obviously to call every one of Tacko (Fall)鈥檚 basketball games and to have him walk through an airport and to see people respond, not just because of his height, but then by the time he was a senior, to people know his story and have him meet people at an airport and speak in different languages because they knew that he was multilingual. And to take a photo, not because he鈥檚 this 7-foot-5 guy, but because that鈥檚 Tacko Fall. Like when we were in New York for the NIT finals and you walk down Broadway, which is every type of person in the world. But it wasn鈥檛 like, “Look at this odd guy.” It was like, that鈥檚 Tacko Fall! So that鈥檚 a sign of not just him, but also for 麻豆原创. And obviously the football success the last few years has also been a huge part of that growth of the brand. And you can go anywhere and people go, “Oh yeah, it鈥檚 麻豆原创.” That鈥檚 great.

Alex Cumming: Well Tacko recently on Jimmy Kimmel, it was so fun to see. And when I was at 鈥 to bring it back just to the Magic for a second, Tacko鈥檚 first game for Boston, back in the Amway for a preseason game, I was there. Whole stadium, “We want Tacko. We want鈥” It was truly something.

Marc Daniels: Yeah.

Alex Cumming: So as you said, 麻豆原创 has had a lot of success, they鈥檝e had continued success over the past years. Recently it鈥檚 been a lot of eyes on us. Going back to your many years here at the university, what games stick out to you? What moments from years ago, recently, what can you just not get out of your head?

Marc Daniels: Wow. I guess I鈥檓 most known for the Mike Hughes kickoff return against South Florida in 2017 and reservation for six of the cabanas.

Alex Cumming: Where did that come from? That鈥檚 just top of the head?

Marc Daniels: Here鈥檚 Hughes the 5, 10 15, 20 25, 30, 40 45 50. He鈥檚 got a reservation for six in the cabanas. He鈥檚 gone! Touch down, boom!

Yeah. People ask, did have that written down? And that鈥檚 not me.

There are some announcers that may do that, and that鈥檚 fine. But I tell people what happened and with that play is Mike鈥檚 back to return a kick and their kicker was really good at just kicking the ball in the end zone. And it was like, wait a minute, that ball is going to be returned.

So that kind of caught me at first. Then Mike made a couple moves. And then, to me I鈥檓 watching and I鈥檓 like, “Okay, he鈥檚 going to break free.” And then as he makes the last cut to get past the kicker, out of the corner of my eye, I鈥檓 watching Knight fans celebrate. And I鈥檓 just seeing him run towards the cabanas.

And that鈥檚 how that came about. It鈥檚 like, he鈥檚 got a reservation for six in the cabanas because I saw that group jumping up and down and that鈥檚 how it happened. There was nothing else. And Mike did all the work. I just sat there, and called it. And yet I guess to some degree we鈥檙e forever connected over that, but there鈥檝e been many great moments over the years.

My first football game at 麻豆原创 was Daunte Culpepper鈥檚 first game in 1995. And I鈥檝e said this for all the years I鈥檝e worked 鈥 that鈥檚 the greatest athlete I鈥檝e ever seen at 麻豆原创. Never seen an athlete like that. And we are blessed to have All Americans, Olympians and record holders, but Daunte was special. He was unique cause the time he came to 麻豆原创, as we were making that growth to become a Division I program, he was absolutely phenomenal. But there鈥檚 been so many great moments over the years. The winner in Alabama, because of what it meant, to so many close calls of going on the road and playing all these teams and being in the game. And then to finally get one of those.

Obviously the 2013 team going to the first Fiesta Bowl was memorable. That team, big games there. The win at Penn State. Beating Louisville, the way they had the season going and getting to that first Fiesta Bowl. And Baylor was such an overwhelming favorite. And 麻豆原创 just beat them in every part of the game.

Obviously the 2017 run. Look, the greatest eight quarters, the most exciting eight quarters of 麻豆原创 football was the South Florida game followed by the Memphis game, which is like more than four quarters. So there鈥檝e been so many wonderful memories, and even games that 麻豆原创 didn鈥檛 win to be able to go and broadcast from. You know were just a unique 鈥 a game that we did win, the first game at Navy. Just to go there and broadcast a game and have an appreciation for that campus and what it stands for.

So I鈥檝e been blessed to be part of some of those, in football, great moments. And the beauty about 麻豆原创 is there are still so many other firsts to happen. So many places that have 100+ years of history, you鈥檙e trying to accomplish something that鈥檚 been done. But we have so many wonderful firsts that are still out there. That鈥檚 why I鈥檓 blessed, I鈥檓 privileged to do what I do because I can鈥檛 wait for the next first to happen.

Alex Cumming: You see so many people still talk about the Alabama kick, and you鈥檙e on social media and all these times these social media pages that are sharing highlights. You鈥檒l always find a 麻豆原创 highlight in there. Blake Bortles amazing toss into the end zone. The Mike Hughes return. Oh my goodness. 2017, there鈥檚 one on YouTube. It鈥檚 like 麻豆原创, USF all-time thriller 2017. It was like 100,000 views. It鈥檚 incredible. Just the highlights of these games. I get chills thinking about it.

Marc Daniels: Yeah. We鈥檝e got a great fan base, so they love that.

Alex Cumming: I鈥檒l say, and then think about, like you said, what鈥檚 coming up, what鈥檚 ahead that a lot of these universities, they鈥檝e had their moments of, “Wow, look at these guys.” And 麻豆原创 hasn鈥檛 had that moment where this is the pinnacle.

Marc Daniels: Right.

Alex Cumming: 麻豆原创 is still climbing.

Marc Daniels: Yeah. I did an interview recently with somebody who asked me, “What makes 麻豆原创 such a unique place?” They鈥檙e asking about football. They, said, “What makes it such a unique place?”

And I said, “Imagine if you are able to go to work every day and they encourage you to be as creative as you can be. Just try stuff. Don鈥檛 worry about failing. If it doesn鈥檛 work, we鈥檒l try something else and just think out of the box as you can.” If you think about that鈥檚 what we become 鈥 different uniforms. We鈥檙e pretty active on social media. We鈥檒l get under the skin of our rivals and opponents. We don鈥檛 have a history that you have to act a certain way. We can go and be the life of the party where someone else goes, “I want to hang out with those guys cause they鈥檙e having the most fun.” I think that鈥檚 one of the biggest advantages that we have is that we鈥檙e still writing our history while others are upholding a history.

And that鈥檚 why I think this is the best time at 麻豆原创. There鈥檚 still so many amazing things that are out there.

Alex Cumming: Very much agree. Someone shared with me once that 麻豆原创 fans are so devout, as opposed to a lot of other teams in Florida, because most of the fans actually went there. The fans actually went there, the families that went there.

Marc Daniels: Yeah. And look, part of the enrollment growth at 麻豆原创 did come from the other brands in this state that either A, maxed out on enrollment, changed whatever they thought their enrollment policies were and a generation looked at 麻豆原创 鈥 and I have a nephew that I think was part of that, where my brother went to Florida State, my sister-in-law went to Florida and he was likely going to go to one or the other. And then something happened. He came to 麻豆原创 and he鈥檚 like, “All the buildings are new. All the dorms are new. What are these four-bedroom suites, as opposed to this aging double that I would live in a brick building that was built in the 1890s?” And other young people said, “Hold on, this campus is gorgeous. It鈥檚 40 minutes to the beach there. It鈥檚 theme parks.” And then that enrollment explosion took place. He鈥檚 got three kids that are going to grow up and likely become Knights. So you鈥檙e right. That鈥檚 how all that developed. And we鈥檙e at the infancy of that. So as those thousands and thousands of alums begin to have families just imagine what happens to our fan base and the generations down the line.

Alex Cumming: The marketing, they do it for us. People say, yeah, 麻豆原创 exists rent free because it is such a, beautiful school, like you said, it鈥檚 so creative. We have such an amazing social media team that works and gets the name out there. The faces out there, the people you recognize them.

Marc Daniels: But again, we can do things that other schools would be a little bit uncomfortable with. Again putting Twitter handles on the back of jerseys at a spring football game made people, “Go wait a minute. What?” And don鈥檛 think for a second, some major brands are like, “That鈥檚 really cool, but we probably can鈥檛 do that because that鈥檚 not our zone.

And that鈥檚 what鈥檚 really cool about us is that we can try things like that. And our space uniforms are so cool. And everybody these days has multiple uniforms. We鈥檙e among those that are like, “What are they wearing next?” When we rolled out our uniforms on game day that鈥檚 a really big deal to our fans and a lot of other places like, “Oh, that鈥檚 cool.”

Alex Cumming: You see there鈥檚 a picture where it says like all the different uniforms and everybody would say, “This is my favorite. I like this combination, this helmet, these pants, these shoes. I have my personal favorite and I鈥檓 certain, you could talk to people, they might have their personal favorites. They might not be for the same reason, you have a memory attached to it. Like you said, it鈥檚 a big deal when you see them coming out of the tunnel. I love it.

So speaking of the players, what about off the field? Players that you鈥檝e gotten to know personally, how have your experiences been, speaking with the people behind the jerseys?

Marc Daniels: Yeah. I tell people all the time the best promoters of 麻豆原创 are our students, our athletes, and the wonderful people in the campus. Their stories are amazing because there鈥檚 so many different stories of those that have traveled far and those that are here local, that grow up and want to be Knights. And I get it when I meet players that come back with their families and, say, “Wow Marc, I remember your calls or talking and listening to you or a conversation on a flight or something like that.” And some of those players were All-Americans have gone to play professionally and others were role players that hardly ever played. And it鈥檚 great to meet them because we have so many wonderful stories in all of our sports. And there鈥檚 some players that I鈥檝e really enjoyed getting to know over the years that have gone on to be successful.

One of the biggest hugs that I got recently 鈥 Latavius Murray, who starred here at 麻豆原创 and聽 is still having a great career in the National Football League. Every time, I get a chance to see and catch up with him to get a huge embrace and players that were part of those first teams. The first bowl team in 2005 and all those guys that went to the NFL. Brandon Marshall has gone to be one of the best receivers in the NFL. And any time I still see Brandon, it鈥檚 as if he鈥檚 a freshman again 鈥 and by the way that freshmen play defense. To remind people, we were so injured and thin at defensive back then that he and Mike Walker later, Mike Sims-Walker, played defense for us back then. But yeah, those are great to to meet people.

Like I said, I love meeting players who go, 鈥淚 want to introduce you to my children.鈥 It makes me feel old, but I鈥檓 honored when that happens. And those are great stories that you connect with those people and they鈥檒l be friends for life.

Alex Cumming: Do you have a moment or a memory that sticks out to you?

Marc Daniels: Yeah. The first thing that sticks out to me, the Griffin twins and Shaquem Griffin and to see the impact that he had on families of teams that we played on the road. I was able to witness families bring children that have some real difficulties in life 鈥 not able to walk or other issues that are gonna make their life a little bit more challenging. And to have him take the time, even though they may be wearing the colors of the team that he鈥檚 going to play in a few hours, and to sit down and look them in the eye and make them smile and make them feel like, you know what, you鈥檙e no different than me and if somebody else says you are different, understand that you can strive to be something.

And I got to watch both of those brothers realize the impact that they could have on people. And to see Shaquem sometimes bend down to talk to a child in a wheelchair or with braces and make them smile, that鈥檚 a lot more than the final score of a football game. And to see a mother in tears because they hadn鈥檛 seen their child鈥檚 smile, that鈥檚 powerful. That鈥檚 far more than, who won and what was the stat sheet today? And I鈥檒l never forget seeing that multiple times watching him do that. I remember at the Peach Bowl there was a media session that I was at that he was a part of and we came out of that and there was a family right there with a young daughter that she was in awe being able to meet him. So you don鈥檛 forget stuff like that.

Alex Cumming: It鈥檚 bigger than the game.

Marc Daniels: Yeah, Yeah, absolutely.

Alex Cumming: Yeah. That鈥檚 a beautiful story. You鈥檙e right that the students, student-athletes, they represent 麻豆原创 so well, they take it with them and they are the brand. They are the face.

Marc Daniels: And it doesn鈥檛 matter the sport. We鈥檙e in an era where I think people really, I hope they do understand, our student-athletes love to represent this university. I mean, they鈥檙e incredibly passionate about winning championships and engaging with fans and giving back. And that鈥檚 a testament to our coaches. You have incredible coaches and we鈥檝e been fortunate to have great athletic leadership, like we do now with Terry Mohajir and his staff and our players I think really feel that. And you see that.

In the field, no matter what the sport is I think our players like everything that we just talked about, like being a little bit different, we鈥檙e on the edge and maybe the opponent doesn鈥檛 really like us and things like that. I think they embrace that situation and environment.

Alex Cumming: Since we鈥檙e here recording this, the practices for the fall season have begun.

Marc Daniels: Yup.

Alex Cumming: What鈥檚 on your mind? What are your predictions for this coming fall? New leadership, same amazing players, and some amazing new faces coming in, too.

Marc Daniels: Yeah. It鈥檒l be very exciting. Coach Malzahn has come in and I think he鈥檚 been phenomenal at bringing his experience over the years as a head coach and setting up a culture and environment that he wants, accountability for the players and expectation of the players, competition, and things like that. But I think he鈥檚 also embraced everything we were talking about of what makes 麻豆原创 unique. He came from a place with a lot of tradition, did things a certain way, and people kind of wondered is he going to understand what is that 麻豆原创 image and that kind of attitude. And he鈥檚 actually really embraced it.

Listen, who doesn鈥檛 want to come and play here in the sun, the fun that we鈥檙e going to have, this great campus, the theme parks, the partnerships we have there, the beach over here? And he wrapped his arms around that, jumped on social media, started telling everybody what鈥檚 so great about this. Use it in recruiting and I kind of wonder where that would be. And he blew me away with how much he said, “Listen, I get it. And I know what our advantages are without even playing a game.” So I think he鈥檚 been great with that. He hired a really good staff.

Look, the expectations are high for 麻豆原创, and I think that鈥檚 good. The team has a chance to be really good. It brings back a number of key players from last year. We lost a lot of key players from last year鈥檚 team. But Coach Malzahn has brought in a group of transfers that I think could have an immediate impact. Some freshmen that I think we brought in this class are going to step in and help.

So I think we鈥檙e going to be a team that has a chance to win every game. Doesn鈥檛 mean you鈥檙e guaranteed to win every game, but I鈥檓 not quite sure there鈥檚 a game you鈥檙e like, “Hey, they鈥檙e just that much better than us.” I think that you want to get to a level that you feel that way about your program and believe me, I remember the days you were like, “We鈥檙e here to pick up a check and stick around.” But this team has the chance to win every game.

And I will say this, that over the years, because of our accomplishments and our reputation, when we go on the road, everybody wants to beat 麻豆原创. Everybody wants to beat 麻豆原创. And you know what, that鈥檚 what you want. You want that where you鈥檙e the big ticket in town. When you come to town, People are like, “Oh I don鈥檛 like them. I want to root against them.” And you play a brand of football that鈥檚 also exciting. So I think it鈥檚 got a chance to be a really great 2021 season, but understand you鈥檙e going to get everybody鈥檚 best game week in and week out.

Alex Cumming: That鈥檚 what the fans want. I鈥檓 certain for yourself to announce those are the most fun. The ones where maybe the nail biters, the one when you鈥檙e on your edge, you don鈥檛 know what to expect.

Marc Daniels: Yeah, exactly. And who鈥檚 going to make the big play? Who鈥檚 going to become the highlight for that day? And I think we got a chance to have a lot of those big plays this year. Obviously, Dillon Gabriel鈥檚 a special quarterback and he鈥檒l have a big year. The entire offensive line is back. And even though we did lose some players, the backfield and wide receiver. We have a ton of talent there. I think the defense is going to be a lot better with some of the additions the coaches brought in.

So the stage is set and it鈥檚 a huge first big game. Boise State鈥檚 a really good team, a heavy favorite to win their conference. Great. I mean they鈥檙e 20 years into this run of being a heavy favorite every time out, of double digit wins and things like that. So it鈥檚 a great matchup.

Alex Cumming: That home opener in September. I鈥檓 counting the days. The energy there is going to be like nothing else. Coming out of last season where limited capacity of fans to have the whole place back and bouncing.

Marc Daniels: Yeah. We think that there鈥檒l be a record demand for student tickets and everything, and you can feel that now. Obviously the stadium is selling out and it鈥檒l be a special place because we know when that place is packed the crowd can make a difference. It鈥檚 one of the reasons why it is hard for us to get home games. Everybody鈥檚 asking about schedules and it鈥檚 hard to get teams to come here and play because the reputation is it鈥檚 a tough place to go win.

Alex Cumming: They know. They鈥檙e aware of the energy that the students, that the fans bring.

Marc Daniels: Absolutely.

Alex Cumming: There鈥檚 no place like it.

In your perspective, we were talking about football here, so far what have your impressions been? Terry Mohajir and Coach Malzahn.

Marc Daniels: Terry is one of the most energetic people you鈥檒l ever come across.

It鈥檚 hard to spend 10 minutes and not leave excited with an adrenaline rush of, “Okay, what can I do?” So I can see why his personality is contagious. I鈥檝e been so impressed the way he鈥檚 come in, and also has embraced the culture of 麻豆原创, see what the vision is, add to it his own ideas on how to help the 麻豆原创 brand grow, and so he鈥檚 been great. He, I think was the right person, the right time for 麻豆原创. And I think loves what the 麻豆原创 opportunity is. So he鈥檚 brought in some great people that have worked with him before, as well as embracing some of the people that have been here.

One of the management things I love about Terry is that he encourages creativity. Give me some ideas, let鈥檚 go get some stuff done, let鈥檚 go have some fun, let鈥檚 be successful and let鈥檚 go do it. You know, let鈥檚 not procrastinate, let鈥檚 go do something. I love that about him.

And same when Dr. Cartwright came in with a vision and a challenging first year, obviously with COVID, and fortunate to get a little bit of time with him and to hear him talk about the vision for 麻豆原创, I mean as big as we are now, and where he wants to take it. So to have that type of leadership is great and not saying, “Hey, we鈥檒l live off the success of the past. We want to keep growing.” So it鈥檚 awesome.

And like I said, I think Gus has been great to come in and also welcome that personality. And then there are great coaches and athletics 鈥 and I hope people have had a chance if you haven鈥檛 to meet all of our coaches. We have an amazing group of people that is really special to have at 麻豆原创. And I know Terry recognized that quickly coming here. We do compete for championships all the time and it鈥檚 because the loyalty of a lot of these coaches that say, “Hey, this is a great place to be at.” So it鈥檚 a really good vibe right now.

Alex Cumming: From the interviews that you鈥檝e done with both of them, and from my speaking with President Cartwright, I鈥檝e seen this overarching theme of group think. That I鈥檓 not 100%. I want to hear from everybody. I wanna hear from all of y鈥檃ll what you have to say. Who can contribute? So it鈥檚 not just this one-track mind, cause you all know something that I don鈥檛, let鈥檚 work together and go forward with it.

Marc Daniels: Yeah. Oh, absolutely. Again, I鈥檝e had a chance to talk with Dr. Cartwright a couple of times. But the feedback I get from others is exactly that, that he is all ears. And absorbs that and then says, “Okay, what do we all think is best for us?” and then I鈥檒l take the leadership and then we鈥檒l go from there. I think Terry has been the same way.

Terry certainly has a vision of what he wants 麻豆原创 to be, but realizes he needs other people to come aboard for the ride. And that鈥檚 again, it鈥檚 part of the great thing about 麻豆原创 is that we鈥檙e paving the roads of our future. And both of those individuals in their leadership role realize if we lock arms and keep growing, we鈥檙e going to be unstoppable. Which is great because, you know, you always wonder, people coming from other places had their habits of doing things and do they get what we are, but yet they bring an expertise that says, “Here鈥檚 how we can get there even faster and be even bigger.”

Alex Cumming: One thing I appreciate about both of them, and I鈥檒l go back to this transition for the new coaching staff and the new athletics director, it happened very fast. There was some speakings of it, but it happened very fast. And from the moment that I saw that video of Terry Mohajir doing the pushups on the plank on top of the crowd, if you鈥檙e familiar, I said 鈥

Marc Daniels: At Arkansas State.

Alex Cumming: At Arkansas State, yes. I said, “That鈥檚 麻豆原创.”

Marc Daniels: That or the TikTok videos with his kid. Yeah, because you鈥檙e like, “Okay, that guy, yeah with us and everything is going to fit and everything.” And like I said, his energy is fantastic. He just has a great passion that it鈥檚 hard to be around him and not feel the same type of passion, which is great.

Alex Cumming: What I love so much about 麻豆原创 through the brand, and the idea, and the coaching, and the student-athletes they have personality and a sense of humor about themselves.

Marc Daniels: Yeah.

Alex Cumming: They understand. They take their job seriously, but not themselves too seriously that they can understand that it鈥檚 OK to crack a joke every now and then, it鈥檚 OK to bring your personality to the table. And that鈥檚 what I love seeing every time with all these people. It makes the students feel more involved with it that they say, “They鈥檙e like us. They understand and they鈥檙e not stern in their ways, that they can let loose a bit.”

Marc Daniels: Yeah. And it stretches far beyond athletics. There are some historical sites on this campus, but it鈥檚 interesting. You could walk on some campuses in the state or across the country, and someone can tell you the story of that building from 1797. You can walk across some bodies of water and someone say, “I remember fighting to get a duck in that pond right there because that was so important. And that鈥檚, what鈥檚 unique about 麻豆原创.”

Alex Cumming: It鈥檚 I love it. So now, Marc, I鈥檓 going to turn the tables on you and I鈥檓 going to shoot you some lightning round questions.

Marc Daniels: I鈥檓 ready.

Alex Cumming: You ready?

Marc Daniels: Let鈥檚 do it.

Alex Cumming: Alright. Alright. Here we go. Football or basketball?

Marc Daniels: Neither, I can鈥檛 pick one or the other. You can鈥檛 do that. Football is unique because, again, the presentation from a broadcast standpoint, it鈥檚 six, six and a half hours. It鈥檚 an entire week really preparing for broadcast. Basketball it鈥檚 a two and a half hour broadcast. It鈥檚 fast pace and from one game you鈥檙e onto the next game. They鈥檙e each unique in their own way.

Alex Cumming: Good answer. Citronaut or Knugget?

Marc Daniels: Oh.

Alex Cumming: I know. I know. It鈥檚 almost blasphemy, but what鈥檚 your answer here, Marc?

Marc Daniels: Wow. I do like Citronaut a little bit more. Knugget鈥檚 adorable, but Citronaut is 鈥 so many people ask, “Why don鈥檛 we switch that?” I鈥檓 like, “No, that鈥檚 what makes Citronaut unique is that, it鈥檚 there, it comes once in a while and everything and it just kind of goes away.” But again, that鈥檚 also part of, what鈥檚 really cool about us. You can have all those things. I do love Knugget, but Citronaut is pretty cool.

Alex Cumming: How can you not love both? We鈥檙e simultaneously Knight Nation and 鈥楴aut Nation.

Marc Daniels: Yeah.

Alex Cumming: Ready?

Marc Daniels: Yup.

Alex Cumming: Vacation or staycation? We do live in Orlando.

Marc Daniels: Yeah. It鈥檚 probably staycation. Just because of my schedule, my wife and I don鈥檛 do many trips. So it鈥檚 more staycations, maybe a day trip somewhere and everything because I do travel a lot. If given some free time to relax and not do much it鈥檚 probably a staycation. There鈥檚 a lot of great places around here and I鈥檓 a theme park guy too.

Alex Cumming: During the athletic seasons, do you say, “Alright, nobody planned a wedding, nobody have a baby. Busy, Saturdays, game days.鈥

Marc Daniels: I got married in June and my daughters were born in March in May. So you know 鈥

Alex Cumming: Not a Saturday in October right? Not a Saturday in October. Alright, night or morning?

Marc Daniels: Wow, morning and I鈥檒l tell you why, because I love getting up and saying, “What is today going to be about?” And go tackling the day.

Alex Cumming: 聽Alright, I鈥檓 going to reality TV or dramas?

I鈥檒l answer reality TV because I think junk for the brain once in a while is healthy. And it is a little guilty pleasure with my wife sometimes watching some of the reality TV that she may watch. But I say this as someone that was in the audience at the first ever Survivor final.

Alex Cumming: Really?

Marc Daniels: So that鈥檚 where it started. Yeah, my wife and I went to Hollywood for the first one, when Survivor was Survivor and we were in the studio audience for the first ever final. So I guess that鈥檚 where the reality TV bug started. I never want to be on one of those shows, would never do any of those shows, but then I get a chuckle out of it. And scripted reality TV is hilarious and I just find it totally funny. It鈥檚 fantastically bad.

Alex Cumming: Big time. I totally agree. Are you a savory or sweet man?

Marc Daniels: Used to be, but sweets for the most part are gone. This is somebody that lost 70 pounds a few years ago, so now I鈥檓 a nutritious nut. Once in a while, I would treat myself. But sweets used to be one of the downfalls. Sweets are great, but I just don鈥檛 do it as much.

Alex Cumming: I hear that. Now you鈥檙e traveling a lot. Window or aisle seat?

Marc Daniels: Claustrophobic, so I have to sit in the aisle.

Alex Cumming: Oh.

Marc Daniels: Yeah. The aisle鈥檚 really big. You do not want to be on a flight with a window with me cause you likely wouldn鈥檛 get me on that flight. I鈥檇 wait until the next flight. Yeah. And it wasn鈥檛 always the case. It actually happened on a flight back from a 麻豆原创 basketball game. And I just had a moment where a panic attack and it was, “Whoa.” And since then I have to sit in the aisle. Yeah. Plus I want to be near the beverage cart. It鈥檚 just so much fun鈥

Alex Cumming: Reaching over people that鈥檚 鈥

Marc Daniels: Well there鈥檚 nothing like watching a group of individuals just respond to, “Wait a minute. Is that a bag of pretzels and a half a can of soda? Because I鈥檓 lined up for that.”

Alex Cumming: “For me?”

Marc Daniels: “I have a choice? Unbelievable.”

Alex Cumming: “Diet or regular?” Alright, here鈥檚 the last one. Best sporting event you鈥檝e ever witnessed in person?

Marc Daniels: Wow.

Alex Cumming: I鈥檓 here with the heavy hitters.

Marc Daniels: Is it 麻豆原创 or non-麻豆原创?

Alex Cumming: Let鈥檚 do both.

Marc Daniels: The Scott Norwood鈥檚 missed kick against the Giants when they won the Super Bowl, and as a Giants fan, it was incredible.

There鈥檚 an amazing story behind that. Between cousins and friends, there was about a dozen of us and when the week began, nobody had tickets and then we ended up all getting into the game, but that鈥檚 a story for another day. So that鈥檚 the best non-麻豆原创 sports moment that I was ever at because we celebrated a missed field goal and the Giants won.

It鈥檚 really hard to pick for 麻豆原创. So I鈥檒l give you two. Look football, the Mike Hughes return because to me it鈥檚 the it鈥檚 the greatest football game that I鈥檝e ever been a part of 鈥 until the next week against Memphis when that was the next greatest game. But I think the Hughes return was really special because of that game, everything going on. It鈥檚 not that the Peach Bowl victory wasn鈥檛 or the Fiesta Bowl victory wasn鈥檛.

But I鈥檒l give you a moment that was not a 麻豆原创 win and it was the Duke basketball game because of just how that story developed when the bracket came out. One, we鈥檙e excited to be in, playing VCU. And then you couldn鈥檛 help but go, “Wait a minute, that鈥檚 Duke in the next game. And if we win it鈥檚 Johnny Dawkins and Coach K and Zion and Tacko. And then that happened. It was one of these weird but incredible feelings after we won because we played the late game that opening night. Duke had already advanced it. There was this case of, we鈥檙e not just isn鈥檛 this cool we鈥檙e going to play Duke. There was like, “This is a game.” And it was supposed to be like, “No, this is Duke.” And I will never forget the buzz of that building. When that game was an hour before tip off, that place was packed. And the vibe when that ball went up, that game was absolutely incredible.

And I could go play by play with you and they should have called the foul on Zion, but they were never going to call the fifth foul. The hook by RJ Barrett that should have been called a foul, and the free throw, and the shove, and how Aubrey Dawkins鈥 shot did not go in. I still don鈥檛 know. Those are more recent ones. But those are two of the great moments.

Alex Cumming: Every year, March ESPN classics. Duke, 麻豆原创 basketball. Every year since then.

Marc Daniels: Yeah. Again, a magical game and all the parties involved with that and Coach K and Johnny Dawkins.

Alex Cumming: Just the storylines.

Marc Daniels: Absolutely unbelievable. The timing was a Sunday night, the CBS, the huge crowd watching across the country, it鈥檚 one of the most viewed 麻豆原创 events ever. So yeah.

Alex Cumming: I was in a rehearsal. I was sneak watching it. I鈥檓 watching it out here, sweating in my costume. It was wild.

Well, I鈥檒l move here into this final section. What advice would you give to somebody who wants to do what you do?

Marc Daniels: Have dreams, have goals, but have an open mind that you鈥檙e living in the most amazing time that you could try anything. And you鈥檒l never know where you鈥檙e going to end up because if you say, “I want to be a broadcaster today,” is so many things than when I said, “I think I want to get involved in broadcasting.” Between social media, the many platforms that you can broadcast. You hold your iPhone, you鈥檙e walking production company. There鈥檚 so many ways to send a message. So have an open mind don鈥檛 necessarily be obsessed with being in front of the camera, behind the camera is an amazing world of creativity. There鈥檚 so many different opportunities.

So I would tell somebody have dreams and goals, but have an open mind to go left, go right, go down the middle, take the road that looks like it鈥檚 a little bit more challenging. Embrace opportunities. Don鈥檛 be afraid to fail, and you never know where you鈥檙e going to land.

I went to college with somebody that only wanted to be involved in front of the camera. He wanted to be on sports and everything. And he went on to basically be one of the key people at Cartoon Network and would have been like, “What?” It鈥檚 like most of the cartoons you saw in the 鈥90s he brought over to this. Just, you never know the point is he had no idea he wanted to do that, now obsessed with that. And it鈥檚 a great time to create. You could create a movie on your phone. The applications that are available, there鈥檚 nothing anybody can鈥檛 create today.

Alex Cumming: As somebody who loves broadcasting, I appreciate hearing that. It鈥檚 always good.

Marc Daniels: And learn how to write. Writing 鈥榮 priceless. Writing will pay you back. If you love to write stories, if you just loved to write anything, write because it will always give you back. It鈥檚 one of the greatest tools you can have. And a lot of people in broadcasting never do that, they never 鈥 I love writing columns. I write columns for the radio stations, website. I鈥檝e written columns for 麻豆原创 and everything, and I love it. It鈥檚 great. It鈥檚 the ultimate form of storytelling because you鈥檙e trying to put into words what someone鈥檚 going to visualize. And it鈥檚 incredibly powerful when that happens and it connects and someone can actually read what you wrote and visualize it. And if they do it the way you want it to, then you broke the formula and it works.

It鈥檚 one of the great things I love about radio. It鈥檚 my job to paint the picture for somebody. It鈥檚 my job to let them know, not just score, down, distance, how much time is left. Is it warm? Is it cold? Is it tense? Is it a gray day? Is it a physical day? What鈥檚 the game like? What鈥檚 happening? Who鈥檚 the start of nowhere? Give me this little bit of information to make me care more about that player that just made that play and the art of storytelling. It鈥檚 incredible. And when it works, it works. And it鈥檚 a beautiful thing.

Alex Cumming: When it works there鈥檚 nothing like that.

Marc Daniels: Yeah, it鈥檚 awesome.

Alex Cumming: And I鈥檒l close with this, what鈥檚 one thing that you鈥檙e still hoping to.do?

Marc Daniels: Call the first football national championship for 麻豆原创, what are you talking about? ,That鈥檚 it, man. That鈥檚 it. And hopefully many of them. I really look, again, I am blessed and privileged to do what I do at 麻豆原创. And as I鈥檝e said, I have been so fortunate to be able to broadcast many firsts at 麻豆原创, but there are so many more and I want to be a part of those. And there鈥檚 so many more great moments that I want to see. And if I can be a part of some way, that excites me.

I love the next game because you never know what鈥檚 going to happen. I love the next moment. I love going to a game I鈥檓 not even broadcasting because it may come down to the final seconds and someone may become a hero. I love to learn the stories of our student-athletes and our coaches.

I just want to keep on being there for those memorable moments. What鈥檚 going to be the next reservation for six? I don鈥檛 know. But man, I want to find out.

Alex Cumming: What鈥檚 the next line that people are going to come up to you.

Marc Daniels: Yeah. And I have no idea what it is, but man, I can not wait for that to happen.

Alex Cumming: The days where they come and say, “Hey, can you do the line?” And you鈥檙e like, “Oh, which one?”

Marc Daniels: I love it though. So I don鈥檛 know when it鈥檚 going to be, what sport, where I鈥檒l be, but man, I am looking forward to being there.

Alex Cumming: I look so forward to hearing you announce those games and the first 麻豆原创 national championship game that you鈥檙e announcing. That鈥檒l be something. I look forward to seeing you there. Marc, this conversation, I鈥檝e enjoyed it so much.

Marc Daniels: Thank you. I appreciate that.

Alex Cumming: I want to say thank you so much for coming on, it鈥檚 been such an honor and a pleasure to get to speak with you.

Marc Daniels: Thank you so much. It was great. Thanks for having me appreciate it.

Alex Cumming: Thanks again for listening. Be sure to stream and download on whatever platform you use to listen to podcasts. I hope you鈥檙e enjoying learning how Knights are making a positive impact in our community, our nation and the world. And hey, if you鈥檙e doing something cool, whether that鈥檚 at 麻豆原创 or somewhere you took 麻豆原创 that we should know about, send us an email at socialmedia@ucf.edu, and maybe we鈥檒l see you on an episode in the future. Go Knights, and Charge On!

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麻豆原创 Podcast: Developing the Moderna COVID-19 Vaccine /news/developing-the-moderna-covid-19-vaccine-podcast/ Mon, 12 Jul 2021 13:45:42 +0000 /news/?p=121520 The 麻豆原创 alum shares about his success in leading the charge to create Moderna鈥檚 COVID-19 vaccine and opening up the possibilities for the future of medicine.

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In this week鈥檚聽episode of the 麻豆原创 podcast, Knights Do That, we speak with 麻豆原创 grad Darin Edwards 鈥97 鈥10MS 鈥11PhD, director of immunology at Moderna.

Edwards earned his bachelor鈥檚 degree in biology, master鈥檚 degree in 聽master鈥檚 degree in molecular biology听补苍诲听doctorate in biomedical sciences with a focus on neuroscience at 麻豆原创 in 2011 and has an impressive resume including, most recently leading the research and development for the COVID-19 vaccine. Edwards discusses what it was like working on the COVID-19 vaccine, the moment it was released and what he looks forward to most as we approach a return to pre-pandemic work and life.

Edwards is also the cover story in the summer issue of Pegasus magazine.

Produced by 麻豆原创, the podcast highlights students, faculty, staff, administrators and alumni who do incredible things on campus, in the community and around the globe.

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Zoom screen shot of Darin Edwards and Alex Cumming
Darin Edwards joined the Knights Do That podcast over a video call from his home office.

Transcript

Darin Edwards: 聽Honestly it was one of the best moments of my life 鈥 seeing those pictures of my parents with needles in arms, it was so incredibly satisfying and emotional at the same time. It was one of the main drivers of the work that I did, and knowing that shortly after they got that dose, that they were going to be protected and they were not going to have a severe outcome to this horrible disease, it was such an amazing moment for me.

Alex Cumming: I recently had the pleasure of speaking with Darin Edwards, a 麻豆原创 alum and the director of immunology at Moderna. You know that company who developed a COVID 19 vaccine? Darin earned his bachelor鈥檚 degree in biology, master鈥檚 degree in molecular biology and doctorate in biomedical sciences with a focus on neuroscience at 麻豆原创 in 2011. Darin has an impressive resume from computer programming to, of course, most recently leading the research for the COVID-19 vaccine and a deep love for all things 麻豆原创, especially in Knights Football.

We get into what it was like working on the vaccine, the moment it was released and what he looks forward to most,as we approach a return to pre-pandemic work and life.

When you started, you were working out in programming before pursuing your master鈥檚 and then getting your Ph.D. in biomedical sciences. How did you know that it was time to pursue a new interest to go back to school?

Darin Edwards: I actually joined a company called Gardner back during the whole dot-com boom. As I had some experience developing a software that was after I did my undergraduate work at 麻豆原创. When I got my degree in biology and molecular biology, always intending to go to the next step, to get my Ph.D. But as you know, when you鈥檙e young in your early 20s, money does draw. So I wanted to make a bit of money before I went back and did my Ph.D. work. That actually lasted all the way through my 20s. So all the way till I was almost 30. And although I was good at programming, it wasn鈥檛 a passion.

My passion was really geared more toward helping people, doing things that might have more of an impact on global health. So I saw the opportunity to rejoin 麻豆原创鈥檚 graduate program. And I聽jumped at it, went back to school and not only changed my focus, but obviously changed my whole career.

Alex Cumming: Yeah. Yeah. I mean, your time at 麻豆原创 when you鈥檙e so young and still figuring out what it is that you鈥檙e so interested in, the ability to get to research and experiment with so many different ventures, it gives you really a lot of opportunities to figure out what it is you want to pursue in the long-term, right?

Darin Edwards: Yeah. And, you know, I had that both from the undergraduate perspective, but also the graduate perspective. As an undergraduate, just the breadth of courses that 麻豆原创 offers really gave me a chance to not only explore the field that I planned to go into, but also to touch on other areas, other aspects of industry or areas of work that I might want to explore in the future. I had somewhat of a foundation in computers prior to the undergraduate time, but I took some computer courses during the time when I was more focused on biology and molecular biology. And that allowed me to actually get into the computer field.

But going back as, a graduate student, one of the really nice things that 麻豆原创 provides and the system that 麻豆原创 has is there鈥檚 a lot of allowance for quite a bit of independence and allowing young scientists, in my case to, grow not only from the perspective of coursework and learning the field in general, but also by allowing students to explore, to develop themselves, to be intellectually curious and to go off on tangents and directions that they might not necessarily be directly focused on.

It allows for people after that academic time to really be comfortable in situations where you just have to think outside of the box. And I think all of us have situations like that in our careers and laying the foundation during the academic time is very important.

Alex Cumming: I like what you said there about the independence to get out and study. Maybe that鈥檚 not the career path you go down, but just the moments you had in there, who knows where something you picked up or something you realize it鈥檚 going to come back in the bigger picture and say, you know, I picked up on that and I thought that was really nice.

Darin Edwards: 聽It makes it fun, too. You know, being able to do something, out of the box, take a course in in bowling, for example. I did that as an undergraduate. It was a lot of fun. Incorporating fun, incorporating adventure during your academic time is very important and I think a 麻豆原创 provides that freedom.

Alex Cumming: 聽How cool. I can imagine that with the rigor and the stress of all the computing that you鈥檙e doing in your major, the ability to go out and knock down a few pins is probably a little bit, it鈥檚 probably a little satisfying.

Darin Edwards: There were a few pints kicked back.

Alex Cumming: Well, that鈥檚 what you gotta do when you鈥檙e out bowling. You worked long hours for day after day and months to develop this vaccine. What were some of the things that you thought about daily that kept you motivated while you were working so hard?

Darin Edwards: Well, I mean, the obvious answer is the pandemic. Being in a situation, a unique situation where I could directly affect how long the pandemic was going to last and also get us back to work, get us back to play, but also to prevent those unfortunate situations where people became very ill and died 鈥 that was the, the natural motivator to keep me going.

My teammates though, in addition to just the pandemic focus, just seeing the sacrifice that was being made across the whole company and not only across the company, but collaborators that we had throughout the pandemic, seeing the sacrifice that was being made by individuals across the globe. Who would I have been聽 to not sacrifice myself and, you know, give up family time to, give up time spent with friends. It was a worthwhile effort. And I was happy to give that part of myself. And fortunately it was very successful.

If you give that much to an effort, you naturally want it to have a successful outcome. And I think, obviously with people getting vaccinated and seeing that restrictions are being lifted, case numbers are dropping it鈥檚 very satisfying and I鈥檓 very happy to have done that for so long.

Alex Cumming: Well, thank you so much. And congratulations.

Darin Edwards: Thank you.

Alex Cumming: To put all the work in that you did throughout that time, getting people back to a sense of normalcy, that they can go out and be with their loved ones. So thank you again for doing what you did so that people can experience time with their loved ones they might not have been able to see for over a year, maybe close to 15 months.

Darin Edwards: Yeah. And you know, there was my own personal aspect to the whole thing, knowing that I have elderly parents, knowing that they were at high risk for severe outcome to COVID-19. That was a personal driver for me.

More than just myself, obviously I wanted to get out and play and not be worried about a disease, but I鈥檓 younger. I鈥檓 not in such a high risk category. My parents and loved ones in that age range were obviously a particular motivator for me.

Alex Cumming: Right. So when your parents got the first dose of the vaccine, how was that as an experience for yourself?

Darin Edwards: It was, you know, honestly it was one of the best moments of my life. Seeing those pictures of my parents with needles in arms 鈥 they actually got their first and second dose at the Orange County Convention Center.

They went through that whole process, that whole cue where, they drove in with their car. My sister actually took them and it was a very smooth and good process. You know, you should be proud what orange county did down there to make it so easy. But she took pictures of each as they got their dose, and it was so incredibly satisfying and emotional at the same time. It was one of the, like I mentioned, one of the main drivers of the work that I did.

And knowing that shortly after they got that dose, that they were going to be protected and they were not going to have a severe outcome to this horrible disease. It was, it was such an amazing moment for me.

Alex Cumming: Yeah, I believe it. That sounds fantastic. In a personal sense and in a professional sense, how were you able to manage such intense work pressure for it all?

Darin Edwards: That鈥檚 a good question. Sometimes. I鈥檓 really not completely sure how, not only myself, but other members of the Moderna team that I鈥檓 partnered with, how we鈥檝e all managed. I think in part it鈥檚 just, we really had to focus on many different areas into different aspects simultaneously. One interesting thing is, during this time we鈥檝e not only been pushing forward this COVID vaccine and working long hours in highly stressful situations to get this forward. We鈥檝e also recognized that this is an opportunity to leverage our mRNA platform against other infectious disease targets. So we鈥檝e had to juggle not only the development of this vaccine, but also growing the company. That鈥檚 outside of the scope of the conversation today, but that has obviously increased the amount of work in parallel to obviously all the work that we鈥檝e performed on that on the COVID vaccine.

One way that I鈥檝e managed it is recognizing those areas that I need to focus on and areas that maybe don鈥檛 require my direct input, and growing my team, developing my team to cover those areas that maybe I don鈥檛 have to have all of the interaction, all of the focus on. That has helped.

In addition to that, we鈥檝e leveraged partnerships. We partnered with the NIH on this effort and not only partnered with the NIH, but partnered with the top people at the NIH. Dr. Barney Graham and his team at the VRC, the vaccine research center, has really assisted and helped in developing, this COVID vaccine, and having such key scientific minds, such amazing researchers engaged in this effort has helped with workload, has helped with stress. Because when you鈥檙e talking to the key scientists the top minds the world, and you鈥檙e coming to a path forward with them, you have confidence. And that confidence in our approach and our strategy, although, there鈥檚 been a lot of stress along the way, at least we鈥檝e had confidence throughout in the approach that we鈥檝e taken.

Alex Cumming: It sounds like the team building, the work that you do with the people around you, that you can鈥檛 bear the load all on your own.

Darin Edwards: Yeah. And that鈥檚 been a key driver for me, in addition to the vaccine. Developing teams getting people to grow and develop and leveraging that growth in the work that we do not only helps with the workload, not only helps with the stress, but there鈥檚 a huge degree of satisfaction seeing people develop and grow. That鈥檚 something that drives me every day, as well.

Alex Cumming: Madrona is a smaller company in comparison to the other corporations that were developing the vaccine. How did such a small team that you were working with do such and achieve big things?

Darin Edwards: I mean, short answer, blood, sweat, and tears.

But a longer answer there鈥檚 several areas, several parts to that answer.

One, we have a platform technology that enables us to do a lot with a small number of people. When you鈥檙e talking about traditional vaccine technologies, you鈥檙e talking about developing each one on an individual basis. As we are a platform company, we can use the same manufacturing line. We can use the same processes for all of our vaccine efforts or even all of our therapeutic vaccine efforts. So technologically that鈥檚 one aspect where we have an advantage.

But it is a small team. We are at the start of the pandemic, I think the total employee count at Moderna was less than 1,000. Contrast that to Pfizer, Johnson and Johnson, they have over 100,000 employees. So what that meant is a team that may number in the thousands at these larger companies, you know, you鈥檙e talking about a small number of people in each team at Moderna. In fact, the core team at Moderna is probably 10 to 15 people total.

So that meant each one of us covering specific areas of this developmental effort had to do what teams of hundreds or thousands were doing it at these larger companies.

Fortunately these key areas were covered by the most talented, innovative dedicated people I鈥檝e ever had the opportunity to work with. People that were entirely focused on the mission and performed above and beyond and I think the outcome really reflects that.

You know, I cover research 鈥 that鈥檚 the area that I cover, you know, the development of the vaccine, the evaluation of the vaccine in animal models. And then the technological aspects and how the vaccine is working, that鈥檚 my area of coverage. I was part of the initial conversation after we got the sequence of SARS-CoV-2, how are we going to tackle this? Okay, here鈥檚 what we鈥檙e going to do. And two days later we had our vaccine and we had the process of evaluating.

But there鈥檚 other areas involved in the developmental process 鈥 things like interacting with the FDA or health agencies around the world, communications with them. Running clinical trials, manufacturing the vaccine, scaling up to a billion doses. That鈥檚 a huge thing. And each one of those areas was covered by an incredibly talented, innovative person.

And no matter what the issue was, no matter how complex, they found a solution. And it enabled us to do in 11 months, what had never been done in that short a period of time. In some ways it was an asset. At a larger company, you鈥檙e going through multiple steps, informing, different groups, identifying strategies and paths forward.

At our company, it鈥檚 a small group. It limited the amount of information driven conversations that we needed to have. So we鈥檙e always just focused on the goal. Okay. What do we do? Okay. Here鈥檚 what we鈥檙e going to do. Let鈥檚 do it. It allowed us to move very quickly. You know, I could pick up the phone at any moment, talk to anybody in my company, from the CEO down. That鈥檚 a rare situation. And it enabled us do what we did, but really it鈥檚 the dedication and the talent of the people that enabled this to happen.

Alex Cumming: With a team like this, these are people that you鈥檙e not going to forget when you go through something like this. So to have such a team that came so close together, I鈥檓 certain you guys will remember each other for years and years and years to come.

Darin Edwards: 聽When you鈥檙e in high school, you always look forward to the 10-year reunion, 20-year reunion. I wouldn鈥檛 be surprised if this core group of people had these reunions, 10, 20, 30 years down the road. And I look forward to that.

You know, during the whole process, people would say, 鈥淥h, this is incredibly hard. But wow what an opportunity.鈥 And one response that I had pretty commonly, 鈥淭his has been amazing. I can鈥檛 wait to look back on it.鈥 Because it was so difficult in the moment, but recognizing that it is a unique and amazing journey that we had gone on and continued to go on. But and I know in hindsight, it鈥檚 going to be a lot more pleasant than it was during.

Alex Cumming: Oh, yeah. I definitely believe it. But to keep such an optimistic outlook on it in the moment, knowing that in retrospect, it鈥檚 one of those situations where you鈥檙e like, won鈥檛 this be a story? Won鈥檛 this be something to share, to tell, you know, the people that I meet, the people who come around me, that I was there. I developed it. I set the world back on path.

Darin Edwards: I鈥檝e already had the opportunity in a few cases to have those conversations with friends down there in Orlando coming down.

I have lifelong friends that live down there and just kind of sharing how it was with people that I love has been as been a lot of fun. I kind of look forward to the day where those conversations have already even been had. And I can just get back to life as normal. But at the same time, it鈥檚 definitely something that I鈥檓 happy I鈥檝e been a part

Alex Cumming: I bet it鈥檚 a great icebreaker at parties.

Darin Edwards: I鈥檒l let you know when I start going to parties.

Alex Cumming: Well, thank you for letting us go back to parties. I appreciate it. So as the lead for the research and the development as the director of immunology at Moderna, what was the process of creating the vaccine like?

Darin Edwards: So I鈥檒l start back in late 2019. So there were reports coming out of a new respiratory virus that was circulating in Wuhan, China. Our CEO actually contacted the director of the NIH before there were even news reports really circulating about this and said that, hey, you know, we probably should start up a vaccine program just in case it鈥檚 needed.

So January 11, the sequence to that virus was posted on Twitter actually. And that day we had a meeting with the NIH, Dr. Barney Graham and his team specifically. We, at that time, had identified that it was a novel coronavirus, one that had not previously appeared. And we at that moment decided that, yes, let鈥檚 go ahead and start the process of developing a vaccine.

The process though starts years in the past. In the years in the past, we had developed the mRNA platform. We had tested it in multiple clinical trials, although we hadn鈥檛 yet had a licensed product because it typically takes more than a decade to develop that and get to licensure.

But we also had a four-year collaboration with the same team at the NIH on MERS, which is a Middle Eastern coronavirus. So we already knew how to tackle coronaviruses and specifically how to tackle them with a messenger RNA vaccine approach. So we applied that very quickly.

Two days later we had our vaccine. So that quickly, we were able to develop the approach. By January 13th, we met again, we aligned on the specific approach and specific sequence that we were actually going to deliver. And 42 days later, we had our clinical trial material. And even before that, we already had our preclinical vaccine material.

So by the end of January, I held the vaccine in my hand and that was January of 2020. And before the pandemic was even declared, we were already testing it in people. So, the vaccine effort has a foundation built on years of research. A vaccine effort in general though, you know, once you have identified an approach 鈥 which we had very quickly, like I mentioned 鈥 then relies on extensive research in preclinical models and also three different clinical study phases 鈥 Phase one, two, and three. And unlike normal situations where you would do that sequentially, we did all that incredibly comprehensively in parallel to enable us to shorten the whole timeline. ]

One reason you don鈥檛 normally do that is cost. So the government support that we were given really helped with compressing those timelines. But I would say this effort that we did was more comprehensive in terms of science than any effort that I鈥檝e ever been part of. And I鈥檝e been a part of, more than 10 different vaccine efforts between my time at Sanofi Pasteur and now at Moderna.

From a scientific evaluation standpoint, from a comprehensive nature, it鈥檚 truly amazing how much work was done in such a short period of time and the quality of that work. And that was a lot in large part driven by the quality of the people, the quality of the scientific laboratories that were performing the work and just the dedication that was being given to the whole process.

Alex Cumming: Would you say a lot of that was stemming from that it was a day to day issue and that there was such an outcry for it. And that there was such pressure externally to say, we can see day to day how this is going along within people, that we have this time crunch, that the sooner, the better?

Darin Edwards: It was that, and it was the focus that was being paid to this problem by top academics, by top government agencies, by my team at Moderna, by everybody in the entire world. And barriers, you know, one of the things that really helped with this whole process is how barriers that are normally there in research were broken down.

Being able to engage with these experts in the academic space and being able to discuss and tackle problems and partneshipr with even other industry representatives 鈥 being able to given the resources and the time at the FDA, in a way that we probably would not normally expect. We can pick up the phone and ask them questions or get feedback very quickly from them.

It all worked together to enable us to compress these timelines as quickly to as short a timeline and a process as what we ended up having. But really overall being able to work as a team and not just as a team at Moderna, but as a team globally to get the information we needed, to get the resources we needed when we needed them.

Alex Cumming: And you said that you had worldwide outreach with people you were discussing with to see how they were coming along with it all, along with being able to talk to anyone within your company, you said from the CEO to people, the people that you needed to speak to with.

Darin Edwards: Yeah. I鈥檒l, give you a couple of examples.

One I鈥檝e mentioned it before, but the partnership with the NIH and the laboratories聽 and the personnel at the NIH, I mean, they work just as hard as we did. And I can recall several instances where we had a particular investigation that we were performing and we needed the data back on an immediate basis and having conversations and meetings at 3 a.m. to make this happen. And there was not a single time where I was unable to get in touch with somebody that I needed to talk to on an immediate basis.

But another example is. The scientific community up in Boston is very strong, both academically and from industry. And the focus of all of those bright minds were turned from the various research efforts that they had going on towards coronavirus and consortiums were put in place. And all of those efforts were really focused back on, on coronavirus. And what that led to is not only identification of the areas that we should be investigating for our vaccine, but also the ability to engage with them to make that happen. Particular safety concerns, for example, that we should be investigating prior to putting this in people. But other areas as well that, we might want further insight and further study into. And that goes beyond just our effort, that goes towards Johnson & Johnson or Pfizer.

The investigator that actually developed the Johnson & Johnson vaccine, I鈥檝e had several dozen conversations with early on during his efforts. In fact, I have a cell review article on the adenovirus vaccine technology and the mRNA vaccine technology with him. Just so people had a greater understanding of what our technology actually does and how it works.

And that openness really helped to not only make the work more palatable, meaning, when you鈥檙e open and you鈥檙e having, good work situations with people like that, it makes a stressful situation not as stressful. But also I think for all of us that enabled us to identify those critical things that we needed to work on.

Alex Cumming: You鈥檝e been working in your field for more than a decade. With this past year and a half, what new lessons did you learn?

Darin Edwards: You know, the first decade of my career in vaccine development really helped set the foundation of how I could operate in this last year and a half. But there were, I mean, literally hundreds of situations that I had never encountered, or my team had never encountered prior to the start of the pandemic.

Leveraging what I had from 麻豆原创, leveraging the time that I spent at Sanofi Pasteur and helped with those situations. But really we had to come up with a new road map. We really had to develop a new approaches and new strategies on the fly. And a lot of times it just came down to as a core team鈥 I mentioned the 10 to 15 critical people that were working during this time 鈥 we just came up with strategies and worked through them in our minds and on paper and identified the path and the strategy that we thought would be most effective.

Fortunately, you know, those road maps seem to have led to the outcome that we needed it to. And I think it鈥檚 obvious that it was successful. But I mean there was worry, there was a stress along the way, not really knowing if what we were doing would ultimately be as effective as what we were hoping for.

When we hit certain milestones 鈥 when we fully enrolled our phase three trial, for example, when we got the outcome, when we found out that we were 94.1% efficacious against any disease and 100% against severe disease 鈥 it not only validated the work, the path that we took, but it was incredibly satisfying.

Those moments, knowing that that we were going to be successful.

Alex Cumming: Many scientists are saying that this won鈥檛 be our last pandemic. What do you think are the lessons that we should learn for being better prepared for future ones?

Darin Edwards: As I鈥檓 more research focused and more vaccine development focused, one of the things that really benefited us for this pandemic is that we did have new technologies that could rapidly respond. And we did have an understanding of coronaviruses in general from a research perspective.

So that foundational research, it鈥檚 very important that we continue, and continue to develop our platform techniques that we can use for a future pandemic, but also for key viruses or our pathogens that we know have the potential to become pandemics, develop our understanding of those viruses to enable us to very quickly and rapidly respond with confidence should another pandemic arise.

You think about coronavirus in general, it could evolve further. We鈥檝e had three recent potential pandemic coronavirus strains: SARS-CoV-1, MERS and now SARS-CoV-2. Fortunately the first two didn鈥檛 evolve into a pandemic. Public health measures actually have controlled those two, although MERS is still around. It has not turned into a pandemic virus.

But further monitoring and assessing approaches that we can take to maybe develop approaches even now that can more universally protect against all these potential pandemic coronaviruses is one strategy that we plan to explore and others plan to explore, but we need a focus to remain on that.

Influenza is another, we have a seasonal influenza vaccine. We鈥檙e developing one at Moderna as well hopefully, which is more effective than the current seasonal viruses, but there are pandemic flu strains, so continued monitoring efforts and continue to research efforts in order to develop novel approaches that could tackle very quickly these pandemic strains should they arise.

I think there鈥檚 also a regulatory aspect. The regulatory process that we went through this past year was a huge part of the time that we spent during the 11 month cycle, prior to the EUA (emergency use authorization). There might be additional and quicker regulatory processes that we could put in place for pandemic situations that would enable a more rapid response.

Alex Cumming: You know, the last year has given so many people so much to reflect on in themselves and how they interact with the world. And I think that coming out with the vaccine and being able to reassess what we might have taken for granted and how we go back into our normal day-to-day lives realizing what鈥檚 important to us, keeping in mind that there are people that have been working tirelessly to make sure that so that this doesn鈥檛 happen again.

And for us to reflect and understand how we as individuals contribute to the greater picture, I think that鈥檚 important to keep in mind.

Darin Edwards: Yeah, definitely. You know, it makes me reflect how much I miss seeing 麻豆原创 football. I look forward to flying down for a couple of games this fall. But I really miss the opportunities that I think we鈥檝e all missed this past year 鈥 spending time with friends, having vacations, having downtime, having fun moments with family. I don鈥檛 think I鈥檓 unique in missing all of those parts of our lives that we took for granted, and we probably shouldn鈥檛 take those for granted.

I mean, I don鈥檛 think the last year was a situation that we should ever consider to be normal.I鈥檓 happy to be part of the solution to get us back to normal. But I think we should all expect and want, things to be normal and for us to remain there. So reflecting on what is important 鈥 I just think that normal state, being able to freely get back and blow off steam by going golfing or going to the beach or going to a 麻豆原创 football game.

I think that all is very important. And I look forward to that.

Alex Cumming: Well, as a big 麻豆原创 sports fan, 聽football and otherwise, thank you. I鈥檓 so excited to see all the fans, making it loud聽 in the Bounce House and鈥

Darin Edwards: Let鈥檚 make it bounce鈥

Alex Cumming: all around campus. I love to hear that. So, Darin what鈥檚 advice that you would give to somebody who wants to do what you鈥檝e done in your career?

Darin Edwards: I think the best advice I can give is, to be flexible, to adjust to situations, to not be afraid, to take chances and take risks, and to approach each situation uniquely.

As a scientist, as somebody that has had more than one career up to this point, there鈥檚 evolution that goes on from a personal and professional level within each role. And I think the best advice I can give for any field for person in any industry in any field is to not be afraid to evolve. And to develop and to be loud when necessary, to give your 聽perspective and to rely a lot of times on personal intuition.

But also to be good to the people that you work with and work for you. That鈥檚 very important to me 鈥 to look for areas and ways that you can develop your team to not only support you, but also to push their careers forward. It pays off from a satisfaction level, but also it pays off from the standpoint of, you have people that you can rely on that have greater capabilities.

But overall, you know, just that flexibility, just move forward in the way that you think. Don鈥檛 think that you鈥檒l be doing the same thing for a long period of time. Nothing stays the same. Be willing to change along with, your changing job or your changing field.

Alex Cumming: Being open to being flexible, being open to new opportunities when they present themselves.

Darin Edwards: Exactly. I mean, I think that not only goes for your job, but life in general. We鈥檙e constantly changing as people, growing, new family started we always need to adjust to the situation.

Alex Cumming: Well, I mean, on a school level, taking account of your major and maybe saying, you know, maybe this isn鈥檛 for me, maybe I want to try dabbling in this.

Darin Edwards: Yeah. And just kind of jumping around, even if you aren鈥檛 changing your major, maybe take a few classes outside of your major just to see what other perspectives that might bring you. And in careers, it鈥檚 valuable that you have breadth. It allows you to pull from multiple disciplines where perhaps other people that don鈥檛 have that breadth are not able to very quickly pivot or evolve as quickly as somebody that has more breadth and more depth.

And I think that is good advice, no matter who you are at what stage in your life.

Alex Cumming: Or taking a bowling class to blow off some steam.

Darin Edwards: Hey, nothing wrong with blowing off steam.

Alex Cumming: Not at all. What鈥檚 one thing that you鈥檙e still hoping to do?

Darin Edwards: Well, I think at some point I鈥檇 really love to go skydiving.

That鈥檚 a good question. I haven鈥檛 really given it 鈥 what鈥檚 next, I haven鈥檛 really given that much thought yet. I think there are from the job that I still have and still love and enjoy, there are a lot of infectious disease targets that are next, ones that we鈥檙e going to plan to use our technology to tackle.

And that鈥檚 an ongoing process and an ongoing effort and from a professional standpoint and from a scientific standpoint, that鈥檚 what鈥檚 next for us. What鈥檚 next for me is, I do look forward to getting back to normal life and going to parties and hopefully going golfing occasionally and getting down for a 麻豆原创 football game.

But also just to continue to push. We still have a lot of work to do. Not only on the current pandemic, you know, it鈥檚 not over in most of the world. We鈥檙e lucky here in the U.S. but it鈥檚 not over in other countries, so there鈥檚 still work to be done there. But also outside of the pandemic, there鈥檚 still work to be done against infectious disease in general, not only against the ones that we currently should be fighting, but also ones that could emerge in the future, future pandemics, for example.

Alex Cumming: 聽Yeah. Well, Darin, I want to say thank you so much for talking with me today. It鈥檚 been such a pleasure and an honor to get to hear from you and to hear your perspective on everything.

Darin Edwards: Thank you so much.

Alex Cumming: Congratulations. And I hope to get to see you at a football game this fall.

Darin Edwards: Hey, I鈥檒l be cheering my head off.

Alex Cumming: Good to talk with you.

Darin Edwards: Yep. Let鈥檚 go Knights!

Alex Cumming: 聽Charge on.

Thanks again for listening. Be sure to stream and download on whatever platform you use to listen to podcasts. I hope you鈥檙e enjoying learning how Knights are making a positive impact in our community, our nation and the world. And hey, if you鈥檙e doing something cool, whether that鈥檚 at 麻豆原创 or somewhere you took 麻豆原创 that we should know about wend us an email at socialmedia@ucf.edu, and maybe we鈥檒l see you on an episode in the future. Go Knights and Charge On.

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apple podcasts icon google podcasts icon pocketcasts icon radio public icon spotify icon darin-alex-kdt Darin Edwards joined the Knights Do That podcast over a video call from his home office.