Annette Khaled, a 麻豆原创 professor and cancer researcher has spent the last eight years studying ways to inhibit breast cancer metastases. (Photo by Suhtling Wong)/news/wp-json/wp/v2/posts/106562/nSupported with funding from the National Institutes of Health (NIH) and the Breast Cancer Research Foundation, she previously was able to show that a molecular complex called a chaperonin (or CCT for short) /news/wp-json/wp/v2/posts/106562/u2014 which helps proteins to fold into functional units /news/wp-json/wp/v2/posts/106562/u2014 is especially active in cancer cells./news/wp-json/wp/v2/posts/106562/n
Her team developed a peptide to blocks the folding mechanism and placed it in a nanoparticle to deliver straight to cancer cells. Without the ability to have their proteins fold, the cancer cells died./news/wp-json/wp/v2/posts/106562/n
Khaled knew her nanoparticle was disabling the folding system but didn/news/wp-json/wp/v2/posts/106562/u2019t know how. Complicating that understanding was the fact that the CCT complex is a giant cellular machine and made up of eight different subunits./news/wp-json/wp/v2/posts/106562/n
In her latest study, Khaled discovered how the cancer killing happened./news/wp-json/wp/v2/posts/106562/n
She discovered that one of the subunits /news/wp-json/wp/v2/posts/106562/u2014 /news/wp-json/wp/v2/posts/106562/u201cSubunit 2/news/wp-json/wp/v2/posts/106562/u201d /news/wp-json/wp/v2/posts/106562/u2014 is the leader that makes the whole cellular system work./news/wp-json/wp/v2/posts/106562/n
/news/wp-json/wp/v2/posts/106562/u201cAdding Subunit 2 can make normal cells act like cancer cells,/news/wp-json/wp/v2/posts/106562/u201d she says. /news/wp-json/wp/v2/posts/106562/u201cSubunit 2 leads and the others follow./news/wp-json/wp/v2/posts/106562/u201d/news/wp-json/wp/v2/posts/106562/n
Defining Subunit 2/news/wp-json/wp/v2/posts/106562/u2019s role took months of study. The 麻豆原创 scientist discovered that adding more Subunit 2 caused cancer cells to grow and move. Depleting the subunit caused cancer cells to ultimately die./news/wp-json/wp/v2/posts/106562/n
/news/wp-json/wp/v2/posts/106562/u201cUnderstanding cancer is like trying to solve a giant jigsaw puzzle,/news/wp-json/wp/v2/posts/106562/u201d Khaled explains. /news/wp-json/wp/v2/posts/106562/u201cAnd with this discovery, we feel like we/news/wp-json/wp/v2/posts/106562/u2019ve found some of the parts that make up the puzzle/news/wp-json/wp/v2/posts/106562/u2019s edge. We all have a little Subunit 2 in our cells and our levels go up and down based on demands for protein-folding. But in cancer cells that need to grow and invade, Subunit 2 seems to be on all the time./news/wp-json/wp/v2/posts/106562/n
“Based on our new research, we can work to discover markers that identify cancer cells in which Subunit 2 is increasing, making these cells susceptible to our nanomedicine./news/wp-json/wp/v2/posts/106562/u201d/news/wp-json/wp/v2/posts/106562/n
The next phase of Khaled/news/wp-json/wp/v2/posts/106562/u2019s Subunit 2 research was advanced by gifts from the Catherine McCaw-Engelman and Family Cancer Research Collaborative and the Hardee Family Foundation. Based on her latest findings in Scientific Reports, Khaled is next turning to detecting circulating cancer cells in blood with high levels of Subunit 2. Such testing could give physicians another indicator of whether the patient/news/wp-json/wp/v2/posts/106562/u2019s cancer is spreading./news/wp-json/wp/v2/posts/106562/n/news/wp-json/wp/v2/posts/106562/u201cWhat I want to do is get these guys,/news/wp-json/wp/v2/posts/106562/u201d Khaled says of her work to stop spreading cancer cells. /news/wp-json/wp/v2/posts/106562/u201cWith this study, we are one step closer./news/wp-json/wp/v2/posts/106562/u201d/news/wp-json/wp/v2/posts/106562/n","protected":false},"excerpt":{"rendered":"
A discovery at the College of Medicine may in the future help detect cancer cells in patients before these cells have a chance to metastasize or spread through the body./news/wp-json/wp/v2/posts/106562/n","protected":false},"author":98,"featured_media":106567,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,12,17],"tags":[14946,979,18082,2270,15761],"tu_author":[],"class_list":["post-106562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-health","category-medicine","tag-annette-khaled","tag-college-of-medicine","tag-health","tag-impact","tag-pegasus-briefs"],"yoast_head":"/news/wp-json/wp/v2/posts/106562/n
麻豆原创 Researcher Finds New Signal That Your Breast Cancer Is Growing | 麻豆原创 News</news/wp-json/wp/v2/posts/106562//title>/news/wp-json/wp/v2/posts/106562/n<meta name=/news/wp-json/wp/v2/posts/106562/"description/news/wp-json/wp/v2/posts/106562/" content=/news/wp-json/wp/v2/posts/106562/"A discovery at the College of Medicine may in the future help detect cancer cells in patients before these cells have a chance to metastasize or spread through the body./news/wp-json/wp/v2/posts/106562/" /news/wp-json/wp/v2/posts/106562//>/news/wp-json/wp/v2/posts/106562/n<meta name=/news/wp-json/wp/v2/posts/106562/"robots/news/wp-json/wp/v2/posts/106562/" content=/news/wp-json/wp/v2/posts/106562/"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1/news/wp-json/wp/v2/posts/106562/" /news/wp-json/wp/v2/posts/106562//>/news/wp-json/wp/v2/posts/106562/n<link rel=/news/wp-json/wp/v2/posts/106562/"canonical/news/wp-json/wp/v2/posts/106562/" 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content=/news/wp-json/wp/v2/posts/106562/"麻豆原创 Researcher Finds New Signal That Your Breast Cancer Is Growing/news/wp-json/wp/v2/posts/106562/" /news/wp-json/wp/v2/posts/106562//>/news/wp-json/wp/v2/posts/106562/n<meta property=/news/wp-json/wp/v2/posts/106562/"og:description/news/wp-json/wp/v2/posts/106562/" content=/news/wp-json/wp/v2/posts/106562/"A discovery at the College of Medicine may in the future help detect cancer cells in patients before these cells have a chance to metastasize or spread through the body./news/wp-json/wp/v2/posts/106562/" /news/wp-json/wp/v2/posts/106562//>/news/wp-json/wp/v2/posts/106562/n<meta property=/news/wp-json/wp/v2/posts/106562/"og:url/news/wp-json/wp/v2/posts/106562/" 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cancer is like trying to solve a giant jigsaw puzzle. 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body.","breadcrumb":{"@id":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//news/news/wp-json/wp/v2/posts/106562//ucf-researcher-finds-new-signal-that-your-breast-cancer-is-growing/news/wp-json/wp/v2/posts/106562//#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//news/news/wp-json/wp/v2/posts/106562//ucf-researcher-finds-new-signal-that-your-breast-cancer-is-growing/news/wp-json/wp/v2/posts/106562//"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//news/news/wp-json/wp/v2/posts/106562//ucf-researcher-finds-new-signal-that-your-breast-cancer-is-growing/news/wp-json/wp/v2/posts/106562//#primaryimage","url":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//wp-content/news/wp-json/wp/v2/posts/106562//blogs.dir/news/wp-json/wp/v2/posts/106562//20/news/wp-json/wp/v2/posts/106562//files/news/wp-json/wp/v2/posts/106562//2020/news/wp-json/wp/v2/posts/106562//02/news/wp-json/wp/v2/posts/106562//breast-cancer-signal.jpg","contentUrl":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//wp-content/news/wp-json/wp/v2/posts/106562//blogs.dir/news/wp-json/wp/v2/posts/106562//20/news/wp-json/wp/v2/posts/106562//files/news/wp-json/wp/v2/posts/106562//2020/news/wp-json/wp/v2/posts/106562//02/news/wp-json/wp/v2/posts/106562//breast-cancer-signal.jpg","width":1200,"height":800,"caption":"/news/wp-json/wp/v2/posts/106562/u201cUnderstanding cancer is like trying to solve a giant jigsaw puzzle. And with this discovery, we feel like we/news/wp-json/wp/v2/posts/106562/u2019ve found some of the parts that make up the puzzle/news/wp-json/wp/v2/posts/106562/u2019s edge,/news/wp-json/wp/v2/posts/106562/" says Annette Khaled, a 麻豆原创 professor who leads the medical school/news/wp-json/wp/v2/posts/106562/u2019s cancer research division."},{"@type":"BreadcrumbList","@id":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//news/news/wp-json/wp/v2/posts/106562//ucf-researcher-finds-new-signal-that-your-breast-cancer-is-growing/news/wp-json/wp/v2/posts/106562//#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:/news/wp-json/wp/v2/posts/106562///news/wp-json/wp/v2/posts/106562//www.ucf.edu/news/wp-json/wp/v2/posts/106562//news/news/wp-json/wp/v2/posts/106562//"},{"@type":"ListItem","position":2,"name":"麻豆原创 Researcher Finds New Signal That Your Breast Cancer Is 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