{"id":151231,"date":"2026-02-27T09:29:37","date_gmt":"2026-02-27T14:29:37","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//news/news/wp-json/wp/v2/posts/151231//?p=151231"},"modified":"2026-02-27T11:22:34","modified_gmt":"2026-02-27T16:22:34","slug":"ucf-researcher-developing-new-therapy-to-treat-diabetic-neuropathy","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//news/news/wp-json/wp/v2/posts/151231//ucf-researcher-developing-new-therapy-to-treat-diabetic-neuropathy/news/wp-json/wp/v2/posts/151231//","title":{"rendered":"麻豆原创 Researcher Developing New Therapy to Treat Diabetic Neuropathy"},"content":{"rendered":"<p>Neuropathy /news/wp-json/wp/v2/posts/151231/u2014 chronic pain, numbness and tingling in the hands and feet /news/wp-json/wp/v2/posts/151231/u2014 is a challenging fact of life for many patients with Type 1 diabetes.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>Thanks to a&nbsp;new&nbsp;National Institutes of Health&nbsp;grant,&nbsp;a&nbsp;<a href=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//med.ucf.edu/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231/">麻豆原创&nbsp;College of Medicine</news/wp-json/wp/v2/posts/151231//a>&nbsp;scientist&nbsp;is investigating&nbsp;a new approach&nbsp;to&nbsp;treat&nbsp;neuropathy&nbsp;without relying on&nbsp;pain pills&nbsp;and anti-depressants.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>Assistant Professor&nbsp;Jim&nbsp;Nichols is focused on&nbsp;overlooked mechanisms in the body that&nbsp;may show how&nbsp;the&nbsp;inability to make insulin&nbsp;has&nbsp;/news/wp-json/wp/v2/posts/151231/u201cdownstream/news/wp-json/wp/v2/posts/151231/u201d consequences in other areas,&nbsp;such as&nbsp;how the brain processes&nbsp;and registers&nbsp;sensation&nbsp;in the limbs.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>People&nbsp;affected by&nbsp;Type 1 diabetes&nbsp;don/news/wp-json/wp/v2/posts/151231/u2019t&nbsp;produce insulin, the hormone that regulates blood sugar, so patients must inject themselves with insulin to survive.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>Before joining 麻豆原创, Nichols spent many years looking for new causes of diabetic neuropathy. Nichols theorizes that irregularities in the insulin signaling pathway of peripheral nerves may be the key contributor to diabetic neuropathy. Based on the potential of his early findings, the National Institute of Diabetes and Digestive and Kidney Diseases, which is under the NIH, recently awarded 麻豆原创 a $747,000 grant to expand that research.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<figure id=/news/wp-json/wp/v2/posts/151231/"attachment_151234/news/wp-json/wp/v2/posts/151231/" style=/news/wp-json/wp/v2/posts/151231/"max-width: 1200px;/news/wp-json/wp/v2/posts/151231/" class=/news/wp-json/wp/v2/posts/151231/"figure mx-auto d-block/news/wp-json/wp/v2/posts/151231/"><noscript><img decoding=/news/wp-json/wp/v2/posts/151231/"async/news/wp-json/wp/v2/posts/151231/" width=/news/wp-json/wp/v2/posts/151231/"1200/news/wp-json/wp/v2/posts/151231/" height=/news/wp-json/wp/v2/posts/151231/"800/news/wp-json/wp/v2/posts/151231/" class=/news/wp-json/wp/v2/posts/151231/"figure-img size-full wp-image-151234 img-fluid/news/wp-json/wp/v2/posts/151231/" 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src=/news/wp-json/wp/v2/posts/151231/"data:image/news/wp-json/wp/v2/posts/151231//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/151231/" alt=/news/wp-json/wp/v2/posts/151231/"Man points to a screen with medical imaging on it as young woman in lab coat observes/news/wp-json/wp/v2/posts/151231/" srcset=/news/wp-json/wp/v2/posts/151231/"data:image/news/wp-json/wp/v2/posts/151231//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/151231/" sizes=/news/wp-json/wp/v2/posts/151231/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/151231/" data-srcset=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//wp-content/news/wp-json/wp/v2/posts/151231//blogs.dir/news/wp-json/wp/v2/posts/151231//20/news/wp-json/wp/v2/posts/151231//files/news/wp-json/wp/v2/posts/151231//2026/news/wp-json/wp/v2/posts/151231//02/news/wp-json/wp/v2/posts/151231//Nichols-student-diabetes-research.jpg 1200w, https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//wp-content/news/wp-json/wp/v2/posts/151231//blogs.dir/news/wp-json/wp/v2/posts/151231//20/news/wp-json/wp/v2/posts/151231//files/news/wp-json/wp/v2/posts/151231//2026/news/wp-json/wp/v2/posts/151231//02/news/wp-json/wp/v2/posts/151231//Nichols-student-diabetes-research-300x200.jpg 300w, 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https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//wp-content/news/wp-json/wp/v2/posts/151231//blogs.dir/news/wp-json/wp/v2/posts/151231//20/news/wp-json/wp/v2/posts/151231//files/news/wp-json/wp/v2/posts/151231//2026/news/wp-json/wp/v2/posts/151231//02/news/wp-json/wp/v2/posts/151231//Nichols-student-diabetes-research-360x240.jpg 360w/news/wp-json/wp/v2/posts/151231/" data-src=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//wp-content/news/wp-json/wp/v2/posts/151231//blogs.dir/news/wp-json/wp/v2/posts/151231//20/news/wp-json/wp/v2/posts/151231//files/news/wp-json/wp/v2/posts/151231//2026/news/wp-json/wp/v2/posts/151231//02/news/wp-json/wp/v2/posts/151231//Nichols-student-diabetes-research.jpg/news/wp-json/wp/v2/posts/151231/"><figcaption class=/news/wp-json/wp/v2/posts/151231/"figure-caption/news/wp-json/wp/v2/posts/151231/">Hollie Hayes /news/wp-json/wp/v2/posts/151231/u201920 serves as a lab manager with Assistant Professor Jim Nichols&#8217; research team. (Photo by Eddy Duryea &#8217;13)</news/wp-json/wp/v2/posts/151231//figcaption></news/wp-json/wp/v2/posts/151231//figure>/news/wp-json/wp/v2/posts/151231/n<h2>Discovering New Pathways</news/wp-json/wp/v2/posts/151231//h2>/news/wp-json/wp/v2/posts/151231/n<p>One of the challenges of living with diabetes is&nbsp;that patients&nbsp;with neuropathy may lose feeling in their extremities and not feel&nbsp;a cut,&nbsp;blister&nbsp;or&nbsp;injury.&nbsp;Those injuries can&nbsp;become infected and&nbsp;even&nbsp;lead to amputation.&nbsp;Such diabetic complications occur more&nbsp;frequently&nbsp;in patients with poor blood sugar control,&nbsp;so Nichols&nbsp;is hoping that his research will&nbsp;find a treatment&nbsp;to&nbsp;regulate and&nbsp;improve neuron signaling&nbsp;that can be used as part of&nbsp;improved&nbsp;blood sugar management.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>/news/wp-json/wp/v2/posts/151231/u201cWe/news/wp-json/wp/v2/posts/151231/u2019re diving into an area that/news/wp-json/wp/v2/posts/151231/u2019s fresh,/news/wp-json/wp/v2/posts/151231/u201d he says. /news/wp-json/wp/v2/posts/151231/u201cThe research aims we/news/wp-json/wp/v2/posts/151231/u2019re going after are based on the insulin signaling pathway, and how the neuropathy evolves due to insulin dysregulation. Ultimately, we&#8217;re looking at different ways to alter the insulin signaling pathway to prevent nerve degeneration./news/wp-json/wp/v2/posts/151231/u201d</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>During the next three&nbsp;years, Nichols&nbsp;and his team&nbsp;will document the&nbsp;behavior of neurons, their signaling&nbsp;systems&nbsp;and surrounding cells to&nbsp;find ways to regulate them&nbsp;to&nbsp;alleviate symptoms of neuropathy.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>While approved therapeutics such as opioids&nbsp;and&nbsp;antidepressants&nbsp;can curb&nbsp;those&nbsp;symptoms, Nichols&nbsp;hopes&nbsp;his&nbsp;investigational treatment can become a more&nbsp;viable&nbsp;alternative for diabetic&nbsp;patients.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<blockquote><p>/news/wp-json/wp/v2/posts/151231/u201cWe/news/wp-json/wp/v2/posts/151231/u2019re trying to find better therapies./news/wp-json/wp/v2/posts/151231/u201d /news/wp-json/wp/v2/posts/151231/u2014 Assistant Professor Jim Nichols</news/wp-json/wp/v2/posts/151231//p></news/wp-json/wp/v2/posts/151231//blockquote>/news/wp-json/wp/v2/posts/151231/n<p>/news/wp-json/wp/v2/posts/151231/u201cThere are typical pain therapies out there, although we/news/wp-json/wp/v2/posts/151231/u2019re trying to move away from that because diabetic neuropathy isn/news/wp-json/wp/v2/posts/151231/u2019t very amenable to the basic treatments that we have,/news/wp-json/wp/v2/posts/151231/u201d&nbsp;he says. /news/wp-json/wp/v2/posts/151231/u201cWe/news/wp-json/wp/v2/posts/151231/u2019re trying to find better therapies, and that is our goal./news/wp-json/wp/v2/posts/151231/u201d</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<h2>Inspired to Learn and Discover</news/wp-json/wp/v2/posts/151231//h2>/news/wp-json/wp/v2/posts/151231/n<p>Nichols arrived at 麻豆原创 in the summer of 2025, and&nbsp;says&nbsp;his goal is to inspire students to&nbsp;pursue&nbsp;bold new research directions.&nbsp;He encourages students to not fear&nbsp;the failures&nbsp;that lead to success.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>/news/wp-json/wp/v2/posts/151231/u201cOne&nbsp;of the things I tell the students is&nbsp;that we&nbsp;fail fast and we fail safe&nbsp;here,/news/wp-json/wp/v2/posts/151231/u201d he&nbsp;says. /news/wp-json/wp/v2/posts/151231/u201cWhat that means is that you want&nbsp;to fail as many times as&nbsp;you&#8217;re&nbsp;going to fail as fast as possible. You want to get&nbsp;those failures out as fast as possible so that you can learn as fast as possible&nbsp;without having an impact on you or your studies./news/wp-json/wp/v2/posts/151231/u201d</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p><strong>Chisom&nbsp;Akaniru&nbsp;/news/wp-json/wp/v2/posts/151231/u201924MS&nbsp;</news/wp-json/wp/v2/posts/151231//strong>completed her <a href=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//degree/news/wp-json/wp/v2/posts/151231//biotechnology-ms/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231/">master/news/wp-json/wp/v2/posts/151231/u2019s degree in biotechnology</news/wp-json/wp/v2/posts/151231//a> at&nbsp;麻豆原创 after&nbsp;spending&nbsp;nearly five&nbsp;years working in the biomedical field in her home country of Nigeria.&nbsp;Now pursuing a&nbsp;Ph.D.&nbsp;in biomedical sciences, she&nbsp;joined Nichols/news/wp-json/wp/v2/posts/151231/u2019 lab because she wants to help patients like her parents, who both suffered from&nbsp;diabetes.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>/news/wp-json/wp/v2/posts/151231/u201cThis is personal to me because my mom was diabetic and she died from complications with it,/news/wp-json/wp/v2/posts/151231/u201d&nbsp;Akaniru&nbsp;says. /news/wp-json/wp/v2/posts/151231/u201cMy dad&nbsp;now is&nbsp;showing signs of peripheral neuropathy. There are treatments for other comorbidities of diabetes, but I think it could go a long way to have something that could really help neuropathic pain better./news/wp-json/wp/v2/posts/151231/u201d</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p><strong>Hollie Hayes&nbsp;/news/wp-json/wp/v2/posts/151231/u201920&nbsp;</news/wp-json/wp/v2/posts/151231//strong>graduated from 麻豆原创&nbsp;with her <a href=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//degree/news/wp-json/wp/v2/posts/151231//biology-bs/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231/">bachelor/news/wp-json/wp/v2/posts/151231/u2019s degree in biology</news/wp-json/wp/v2/posts/151231//a>&nbsp;and then worked in neuroscience research before&nbsp;joining Nichols/news/wp-json/wp/v2/posts/151231/u2019 lab as a manager.&nbsp;During her time at&nbsp;麻豆原创,&nbsp;she worked on research to&nbsp;fight pediatric&nbsp;tumors and&nbsp;still&nbsp;carries&nbsp;that inspiration&nbsp;today.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>/news/wp-json/wp/v2/posts/151231/u201cIt got me really interested&nbsp;in focusing&nbsp;on&nbsp;helping people who are just suffering with chronic, debilitating pain, and especially anything that comes with nerves,/news/wp-json/wp/v2/posts/151231/u201d Hayes&nbsp;says.&nbsp;/news/wp-json/wp/v2/posts/151231/u201cMy focus is, /news/wp-json/wp/v2/posts/151231/u2018How can I help&nbsp;advance the science and help&nbsp;as many people as possible?/news/wp-json/wp/v2/posts/151231/u2019&nbsp;/news/wp-json/wp/v2/posts/151231/u201d</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<figure id=/news/wp-json/wp/v2/posts/151231/"attachment_151235/news/wp-json/wp/v2/posts/151231/" style=/news/wp-json/wp/v2/posts/151231/"max-width: 1300px;/news/wp-json/wp/v2/posts/151231/" 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class=/news/wp-json/wp/v2/posts/151231/"figure-caption/news/wp-json/wp/v2/posts/151231/">Assistant Professor Jim Nichols and his team of student researchers. (Photo by Eddy Duryea &#8217;13)</news/wp-json/wp/v2/posts/151231//figcaption></news/wp-json/wp/v2/posts/151231//figure>/news/wp-json/wp/v2/posts/151231/n<p><strong>Researcher Credentials:</news/wp-json/wp/v2/posts/151231//strong></news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>Nichols is a graduate of the Mississippi State University College of Veterinary Medicine&nbsp;dual&nbsp;degree&nbsp;program where he examined new therapeutics for multiple sclerosis while completing his veterinary training.&nbsp;He&nbsp;then&nbsp;worked as a postdoctoral research fellow at&nbsp;MD Anderson Cancer Center&nbsp;for five years&nbsp;where he explored&nbsp;pathological mechanisms&nbsp;of pain with a focus on diabetic peripheral neuropathy.&nbsp;After joining 麻豆原创 in&nbsp;2025, Nichols&nbsp;and his&nbsp;team continue to explore the underlying mechanisms of diabetic neuropathy.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p><strong>Funding and Disclosure:</news/wp-json/wp/v2/posts/151231//strong></news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n<p>Research reported in this publication was supported by the National Institute of Diabetes&nbsp;and Digestive&nbsp;and Kidney Diseases of the National Institutes of Health under Award Number&nbsp;R00DK142197. The content is solely the responsibility of the authors and does not necessarily&nbsp;represent&nbsp;the official views of the National Institutes of Health.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n","protected":false},"excerpt":{"rendered":"<p>Through a recently awarded NIH grant, 麻豆原创 Assistant Professor/news/wp-json/wp/v2/posts/151231/u00a0Jim Nichols/news/wp-json/wp/v2/posts/151231/u00a0is/news/wp-json/wp/v2/posts/151231/u00a0pursuing/news/wp-json/wp/v2/posts/151231/u00a0innovative approaches/news/wp-json/wp/v2/posts/151231/u00a0that will help/news/wp-json/wp/v2/posts/151231/u00a0patients with/news/wp-json/wp/v2/posts/151231/u00a0Type 1 diabetes.</news/wp-json/wp/v2/posts/151231//p>/news/wp-json/wp/v2/posts/151231/n","protected":false},"author":98,"featured_media":151233,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[12,17,23],"tags":[488,12892,979,14751,22543],"tu_author":[],"class_list":["post-151231","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-medicine","category-research","tag-biology","tag-biotechnology","tag-college-of-medicine","tag-faculty-excellence","tag-healthcare"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - 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Nichols/news/wp-json/wp/v2/posts/151231/u00a0is/news/wp-json/wp/v2/posts/151231/u00a0pursuing/news/wp-json/wp/v2/posts/151231/u00a0innovative approaches/news/wp-json/wp/v2/posts/151231/u00a0that will help/news/wp-json/wp/v2/posts/151231/u00a0patients with/news/wp-json/wp/v2/posts/151231/u00a0Type 1 diabetes./news/wp-json/wp/v2/posts/151231/" /news/wp-json/wp/v2/posts/151231//>/news/wp-json/wp/v2/posts/151231/n<meta property=/news/wp-json/wp/v2/posts/151231/"og:url/news/wp-json/wp/v2/posts/151231/" content=/news/wp-json/wp/v2/posts/151231/"https:/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231//www.ucf.edu/news/wp-json/wp/v2/posts/151231//news/news/wp-json/wp/v2/posts/151231//ucf-researcher-developing-new-therapy-to-treat-diabetic-neuropathy/news/wp-json/wp/v2/posts/151231///news/wp-json/wp/v2/posts/151231/" /news/wp-json/wp/v2/posts/151231//>/news/wp-json/wp/v2/posts/151231/n<meta 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