  {"id":152885,"date":"2026-05-08T09:00:42","date_gmt":"2026-05-08T13:00:42","guid":{"rendered":"https:\/\/www.ucf.edu\/news\/?p=152885"},"modified":"2026-05-08T08:52:04","modified_gmt":"2026-05-08T12:52:04","slug":"tentacles-in-solution-ucf-research-speeds-up-dna-biosensing","status":"publish","type":"post","link":"https:\/\/www.ucf.edu\/news\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\/","title":{"rendered":"Tentacles in Solution: 麻豆原创 Research Speeds Up DNA Biosensing"},"content":{"rendered":"<p>Detecting disease in a blood sample. Monitoring contaminants in drinking water. Identifying biological threats before they can spread. DNA biosensors play a critical role in each of these, but many rely on a slow process that can miss fleeting signals or delay results.<\/p>\n<p>At 麻豆原创, researchers are developing a new approach inspired by squids, octopuses and other cephalopods, one that doesn\u2019t wait for targets to arrive, but actively reaches out to capture them. Led by <a href=\"https:\/\/sciences.ucf.edu\/chemistry\/person\/dmitry-kolpashchikov\/\">Dmitry Kolpashchikov<\/a>, a professor in 麻豆原创\u2019s <a href=\"https:\/\/sciences.ucf.edu\/chemistry\/\">Department of Chemistry<\/a>, the work introduces a DNA-based system designed to capture target molecules more efficiently by extending into the surrounding solution.<\/p>\n<p>\u201cOne of the biggest challenges in biosensing is something surprisingly simple: molecules take time to move,\u201d Kolpashchikov says. \u201cImagine trying to catch fish in a huge lake with a tiny net, most fish will never come close enough to be caught. Traditional sensors work the same way: they passively wait for target molecules (analytes) to randomly bump into them.\u201d<\/p>\n<p>The project, supported by a $272,000 award from the U.S. National Science Foundation, reframes how biosensors operate, shifting from passive detection toward active engagement.<\/p>\n<h2>Targeting Molecules Through DNA<\/h2>\n<p>Conventional biosensors rely on diffusion, meaning target molecules must randomly move through a solution before encountering a sensing surface. This process, known as mass transport limitation, can slow detection and limit performance in time-sensitive applications.<\/p>\n<p>Kolpashchikov\u2019s approach addresses this constraint by incorporating nanostructures composed of DNA strands that extend outward from the sensor. These flexible extensions function like molecular tentacles, weakly interacting with passing targets and increasing the likelihood that they will be captured.<\/p>\n<p>Rather than waiting for signals to arrive, the system draws them closer.<\/p>\n<h2>Speeding Detection<\/h2>\n<p>The speed at which a sensor can detect its target is often as important as detection sensitivity and specificity. In contexts such as medical diagnostics, environmental monitoring and food safety, delays can reduce reliability or limit usefulness altogether.<\/p>\n<p>By increasing the rate at which target molecules are gathered and concentrated near the sensing surface, the DNA cephalopod approach may enable faster, more responsive detection systems, particularly in applications that depend on real-time or near-real-time analysis.<\/p>\n<p>\u201cSlow sensors can miss short-lived biological signals, allow samples to degrade, and delay responses to threats,\u201d Kolpashchikov says, \u201cFaster detection reduces costs (less time, fewer reagents), improves accuracy, and enables real-time monitoring \u2014 something essential for healthcare, environmental safety, and biosecurity.\u201d<\/p>\n<h2>DNA as Structure and Sensor<\/h2>\n<p>The system uses DNA not only as a recognition element but also as a structural material. Engineered strands extend from the sensor into the surrounding environment, forming a dynamic interface that interacts with nearby molecules.<\/p>\n<p>These extensions do not bind targets permanently at first. Instead, they weakly capture and release them, effectively increasing the local concentration of target molecules near the sensor\u2019s core detection region. This process improves detection efficiency without requiring additional mechanical or chemical input.<\/p>\n<p>By designing DNA nanostructures that actively interact with nearby molecules, the system creates a sensing environment that is more responsive and efficient.<\/p>\n<p>\u201cDNA is uniquely suited for building nanoscale machines,\u201d Kolpashchikov says. \u201cIt\u2019s programmable, predictable and relatively inexpensive.\u201d<\/p>\n<p>In this system, DNA strands self-assemble into a structure resembling a microscopic octopus, what the team calls\u00a0 a \u201c\u2018DNA cephalopod.\u2019.\u201d A central sensor is surrounded by long, flexible \u201c\u2018tentacles\u201d\u2019 that extend into the solution. Each tentacle carries weak binding sites that briefly capture target molecules and pass them along from one site to the next, guiding them toward the center, where the sensor binds them more strongly and triggers detection.<\/p>\n<h2>Applications Across Fields<\/h2>\n<p>The improved speed and sensitivity of this approach expand the potential use of biosensors across multiple domains.<\/p>\n<p>Possible applications include rapid detection of harmful bacteria in water and food systems, early-stage diagnosis through identification of DNA or RNA biomarkers, and forensic analysis requiring precise detection of biological material<\/p>\n<p>By enabling sensors to detect smaller quantities of target molecules more quickly, the technology may support more timely and accurate decision-making in both clinical and field settings.<\/p>\n<blockquote><p>\u201cThe potential applications are broad: rapid disease diagnostics, including early cancer detection, and real-time monitoring of pathogens in water and food. Perhaps most exciting is that this is a general strategy. The same \u2018tentacle\u2019 concept could be applied for detection of proteins and small biological molecules.\u201d \u2014 Dmitry Kolpashchikov, professor of chemistry, 麻豆原创 College of Sciences<\/p><\/blockquote>\n<p>\u201cThis approach could dramatically improve how we detect biological molecules,\u201d Kolpashchikov says. \u201cThe potential applications are broad: rapid disease diagnostics, including early cancer detection, real-time monitoring of pathogens in water and food. Perhaps most exciting is that this is a general strategy. The same \u2018tentacle\u2019 concept could be applied for detection of proteins and small biological molecules.\u201d<\/p>\n<h2>A New Method of Rapid Analyte Detection<\/h2>\n<p>As with many emerging technologies, translating laboratory advances into real-world systems presents challenges. Performance in complex environments, where multiple substances interact simultaneously, remains an area for further study.<\/p>\n<p>Scaling the technology and integrating it into existing diagnostic platforms will also be critical steps in determining its broader applicability.<\/p>\n<p>Rather than treating biosensing as a passive process governed by chance encounters, Kolpashchikov\u2019s work suggests a different model, one in which sensors actively engage with their environment, reaching into the surrounding space to capture what drifts.<\/p>\n<hr \/>\n<p><em>This material is based upon work supported by the U.S. National Science Foundation under Award No. 2555933. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. National Science Foundation.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new nanostructure approach actively captures targets instead of waiting for them \u2014 enabling faster, more accurate detection for healthcare, environmental monitoring and biosecurity.<\/p>\n","protected":false},"author":8713,"featured_media":153012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[23,24],"tags":[54961,982,13545,11412,3280],"tu_author":[],"class_list":["post-152885","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-science-technology","tag-biosensing","tag-college-of-sciences","tag-department-of-chemistry","tag-dmitry-kolpashchikov","tag-nanotechnology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tentacles in Solution: 麻豆原创 Research Speeds Up DNA Biosensing | 麻豆原创 News<\/title>\n<meta name=\"description\" content=\"A new nanostructure approach actively captures targets instead of waiting for them \u2014 enabling faster, more accurate detection for healthcare, environmental monitoring and biosecurity.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ucf.edu\/news\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tentacles in Solution: 麻豆原创 Research Speeds Up DNA Biosensing\" \/>\n<meta property=\"og:description\" content=\"A new nanostructure approach actively captures targets instead of waiting for them \u2014 enabling faster, more accurate detection for healthcare, environmental monitoring and biosecurity.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ucf.edu\/news\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\/\" \/>\n<meta property=\"og:site_name\" content=\"麻豆原创 News | 麻豆原创 Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/麻豆原创\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-08T13:00:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ucf.edu\/wp-content\/blogs.dir\/20\/files\/2026\/05\/麻豆原创_Biosensor.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Andrew Miller\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@麻豆原创\" \/>\n<meta name=\"twitter:site\" content=\"@麻豆原创\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Andrew Miller\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\\\/\"},\"author\":{\"name\":\"Andrew Miller\",\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/#\\\/schema\\\/person\\\/40c9637d00a4df5d09aca311b65cef6a\"},\"headline\":\"Tentacles in Solution: 麻豆原创 Research Speeds Up DNA Biosensing\",\"datePublished\":\"2026-05-08T13:00:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\\\/\"},\"wordCount\":927,\"image\":{\"@id\":\"https:\\\/\\\/www.ucf.edu\\\/news\\\/tentacles-in-solution-ucf-research-speeds-up-dna-biosensing\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ucf.edu\\\/wp-content\\\/blogs.dir\\\/20\\\/files\\\/2026\\\/05\\\/麻豆原创_Biosensor.jpg\",\"keywords\":[\"Biosensing\",\"College of Sciences\",\"Department of Chemistry\",\"Dmitry Kolpashchikov\",\"nanotechnology\"],\"articleSection\":[\"Research\",\"Science &amp; 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