麻豆原创

Anew, first-of-its-kind clinical trial will examine how the brain adapts to advanced, bionic arms in children born without a limb, with the ultimate goal of improving children鈥檚 control of their prosthetic.

The work, which starts this spring, will be led by听, a nonprofit, direct support organization at the 麻豆原创,听听and听. The joint effort brings together expertise from pediatric research, neuroradiology, and bionics.

Approximately four babies in every 10,000 are born missing a limb, according to the U.S. Centers for Disease Control and Prevention. Prosthetics can be a supportive tool for children to perform everyday activities, but little is known about how the brain responds to the addition of an artificial limb.

鈥淟imited research has been conducted on how the brain鈥檚 motor cortex structure changes from congenital听limb loss and subsequent听use of a prosthetic,鈥� says听Albert Manero, 鈥�12 鈥�14MS 鈥�16PhD, executive director and co-founder of Limbitless Solutions.

The four-month clinical trial will examine if Limbitless鈥� prosthetic 鈥� paired with its听听鈥� will impact the motor control center of the brain. Researchers will closely monitor any changes in the signals the brain sends to the muscle groups that direct the bionics鈥� movement.

They will do this using advanced functional magnetic resonance imaging techniques before and after prosthetic use and training. Additionally, researchers will use a method known as tractography 鈥� where MRI scans visualize the nerve pathways 鈥� to identify new or more robust pathways resulting from the training.

The study is unique because it combines advanced imaging techniques with novel prosthetics and video-game-based training to evaluate motor cortex engagement.

鈥淚t may provide new insight to how the brain鈥檚 motor cortex adapts to learning how to use our organic, or robotic, limbs,鈥� Manero says.

Manero will lead the research听study on the Limbitless side as the investigator along with other 麻豆原创 staff and faculty. Chetan Shah,听chair of radiology at Nemours Children鈥檚 Health, Jacksonville, Florida, and based at Wolfson Children鈥檚 Hospital of Jacksonville, will lead the imaging work.

鈥淭his research will help us see how the brain responds to the child鈥檚 newly acquired ability to use a prosthetic hand,鈥� Dr. Shah says. 鈥淭his is a novel way of using existing brain circuits to use an artificial limb, and most importantly, this is a life-changing device for a child both mentally and physically. We are extremely enthusiastic about this research.鈥�

Limbitless Solutions, which Manero co-founded as a graduate student at 麻豆原创 along with听John听Sparkman 鈥�13 鈥�15MS听and听Dominique Courbin 鈥�18, specializes in developing advanced, muscle-based biosensing technology, such as bionic limbs, to empower children and adults in the limb-different community.

The customized prosthetics they create are 3D printed and can be paired with a parent鈥檚 smart phone. The devices even charge like a cell phone, via USB type C.

The exteriors of the devices are artistically designed and customized, with input from each participant. Existing muscles in the residual part of a limb are used to control their function, which is triggered by a person鈥檚 own muscle flex.

In 2016, Limbitless and faculty members听Matt Dombrowski听鈥�08惭贵础听with听麻豆原创鈥檚 School of Visual Arts and Design听and听Peter Smith听鈥�05MS 鈥�12PhD听with听麻豆原创鈥檚 Nicholson School of Communication and Media听created听video games to train children鈥檚 muscles in anticipation of receiving bionic arms. These video games will be leveraged in the trial to support training for the use of the prosthetic limb.

Limbitless Solutions believes no person with a limb difference should be financially burdened to have a bionic arm and plans to provide prosthetics and training systems for the study free of charge.

To learn more about the program and to submit an application to receive information about the study, families are asked to apply here:听. The study is for children ages 9 to 12, and a maximum of five patients will be enrolled in the pilot study.

About Limbitless Solutions

Limbitless Solutions is a nonprofit and direct support organization at 麻豆原创 dedicated to empowering children and adults in the limb difference community. Through personalized, creative, and expressive bionics – provided without financial burden – the team uses innovative technology and interdisciplinary collaboration to develop muscle-based biosensing technology (multi-gesture bionic arms, a hands-free wheelchair control device and interactive video game training).

Undergraduate students from various academic perspectives engage in project-based learning, professional development and research experiences where students put academics into practice in an environment focused on making a difference, as well as professional and technical development.

Previous clinical trials of Limbitless Solutions technology have included examining the听functionality of the bionic arms and their effect on quality of life, the听effectiveness of video-game-based training, and the听ability of a hands-free wheelchair control device to improve independent mobility and quality of life.

Manero received his听doctoral degree听in mechanical engineering and his听尘补蝉迟别谤鈥檚听and听产补肠丑别濒辞谤鈥檚听degrees in aerospace engineering from 麻豆原创. He joined 麻豆原创鈥檚 Office of听Research听in 2017, and holds courtesy research appointments in 麻豆原创鈥檚听Mechanical and Aerospace Engineering Department听in the听College of Engineering and Computer Science, Mayo Clinic鈥檚 Neurology department, and Veterans Affairs Orlando Healthcare System. He is also a member of 麻豆原创鈥檚听Biionix听research cluster.

About Wolfson Children鈥檚 Hospital of Jacksonville

Wolfson Children鈥檚 Hospital听in Jacksonville, Florida, is a part of听Baptist Health, Northeast Florida鈥檚 most comprehensive health system serving every stage of life. Wolfson Children鈥檚 is the only children鈥檚 hospital in Northeast Florida and serves as the pediatric referral center for North Florida, South Georgia and beyond. Staffed 24/7 by pediatric nurses and other healthcare professionals specially trained to work with children, the 216-bed, patient- and family-centered hospital features the latest pediatric medical technology in a welcoming, child-friendly environment. At Wolfson Children鈥檚, nationally recognized pediatric specialists representing nearly every medical and surgical specialty work with pediatricians to provide care for children of all ages with congenital heart conditions, cancer, neurological disorders, diabetes and endocrinology disorders, orthopedic conditions, behavioral health conditions, traumatic injuries, and more. Wolfson Children鈥檚 pediatric institutional partners include听Nemours Children鈥檚 Specialty Care, Jacksonville,听UPMC Children鈥檚 Hospital of Pittsburgh, the听University of Florida College of Medicine 鈥� Jacksonville听and听Mayo Clinic Florida. A Magnet-designated hospital since 2010, Wolfson Children鈥檚 Hospital has been named among the听U.S. News & World Report听50 Best Children鈥檚 Hospitals year after year, and in 2021, was selected as one of only eight children鈥檚 hospitals in the country as a Leapfrog Top Children鈥檚 Hospital, a recognition of patient quality and safety.